Detailed description page of Selected OV_ID


OV_2755 details
Primary information
OV_IDOV_2755
Virus Name Adenovirus
StrainAdCN205
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeNone
Virus aloneNo
Virus in combination iwth drug/radiationVirus strain in combination with miR-34-a
Immune gene induction in virus genomeVirus expressing IL-24 gene
Source of cell lineATCC
Origin of cell lineHuman hepatocellular carcinoma cell line
Cell lineHuh-7
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice xenograft for Huh cell (2 × 10⁶ cell)
In-vivo virus concentration7 × 10⁸ pfu
In-vivo toxicityNA
In-vivo resultComplete regression in tumor volume after 49 days
Mode of deliveryIntratumoral
Pathway inductionInduction of apoptosis, G1 arrest and sensescence
Immunogenic effectInhibition of oncogene and antiapototic gene
Clinical trialNA
PMID23292172