Detailed description page of Selected OV_ID


OV_357 details
Primary information
OV_IDOV_357
Virus Name Adenovirus
StrainAdhz60
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeE1b-deleted mutant
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismAthymic BALB/c nu/nu male mice (subcutaneously injected A549 lung cancer cells, 5 × 10⁶ cells )
In-vivo virus concentration1 × 10⁹ pfu (every 3 days for at total 4 treatments)
In-vivo toxicityNA
In-vivo result41% smaller tumor size compared to the negative control virus AdLacZ
Mode of deliveryIntratumorally
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID26561948