| Primary information |
|---|
| OV_ID | OV_829 |
| Virus Name | Adenovirus |
| Strain | SG611-VSTM1 |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | A VSTM1 gene expression cassette containing VSTM1 cDNA, cytomegalovirus promoter and SV40 polyA was inserted into the genome of SG611 to generate SG611-VSTM1 |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Viral strain in combination with DNR 300 μg/kg |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Xenograft BALB/c nu/nu female mice subcutaneously injected with 1 × 10ⷠK562 cells in a total volume of 100 μl |
| In-vivo virus concentration | 1 × 10⹠pfu/ml |
| In-vivo toxicity | NA |
| In-vivo result | Reduction in tumor volume to 20 cubic millimeter compared to control 880 cubic millimeter after 30 days |
| Mode of delivery | Intratumoral |
| Pathway induction | Enhanced apoptosis activation is observed |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 27472927 |