| Primary information |
|---|
| OV_ID | OV_2211 |
| Virus Name | Newcastle disease virus |
| Strain | wild type |
| Virus type | RNA |
| Virus family | Paramyxoviridae |
| Modification in virus genome | None |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Virus in combination with cisplatin |
| Immune gene induction in virus genome | No |
| Source of cell line | Chinese academy of sciece |
| Origin of cell line | Human small cell lung cancer cell line |
| Cell line | A549 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | BALB/c nude mice xenograft for A549 cell line |
| In-vivo virus concentration | 1 × 10ⷠpfu
|
| In-vivo toxicity | NA |
| In-vivo result | Tumor volume decreased to 500mm after 57 days |
| Mode of delivery | Intratumoral |
| Pathway induction | Induction of caspase and apoptotic pathway as detected by Hoechst staining and TUNEL assay |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 22095029 |