Detailed description page of Selected OV_ID


OV_2211 details
Primary information
OV_IDOV_2211
Virus Name Newcastle disease virus
Strainwild type
Virus typeRNA
Virus familyParamyxoviridae
Modification in virus genomeNone
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with cisplatin
Immune gene induction in virus genomeNo
Source of cell lineChinese academy of sciece
Origin of cell lineHuman small cell lung cancer cell line
Cell lineA549
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice xenograft for A549 cell line
In-vivo virus concentration1 × 10⁷ pfu
In-vivo toxicityNA
In-vivo resultTumor volume decreased to 500mm after 57 days
Mode of deliveryIntratumoral
Pathway inductionInduction of caspase and apoptotic pathway as detected by Hoechst staining and TUNEL assay
Immunogenic effectNA
Clinical trialNA
PMID22095029