| Primary information |
|---|
| OV_ID | OV_3137 |
| Virus Name | Sendai virus |
| Strain | uPA2 |
| Virus type | RNA |
| Virus family | Paramyxoviridae |
| Modification in virus genome | Deletion of M, F gen at cytoplasmic location |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | Japan collection of research bioresources cell bank |
| Origin of cell line | Human anaplastic thyroid carcinoma cell line |
| Cell line | KHM-5M |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | BALB/c nude mice xenograft for KHM-5M cell line (2.5 × 10âµ) |
| In-vivo virus concentration | 1 × 10ⶠCIU/dose
|
| In-vivo toxicity | NA |
| In-vivo result | Reduction in tumor weight and increase in survival time 41.6 +/- 15 days |
| Mode of delivery | Intratumoral |
| Pathway induction | Caspase dependent induction of apoptosis in vivo and in vitro |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 30969451 |