Detailed description page of Selected OV_ID


OV_2805 details
Primary information
OV_IDOV_2805
Virus Name Adenovirus
StrainAd.sp-E1A-TSLC1
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeDeletion of 24bp with in E1A gene and insertion of TSLC1 gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman lung cancer cell line
Cell lineA549
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice xenograft for A549
In-vivo virus concentration5 × 10⁸ pfu
In-vivo toxicityNA
In-vivo resultSignificant reduction in tumor volume and increased in survival rate fro 15% to 87% at day 60
Mode of deliveryIntratumoral
Pathway inductionInduction of apotosis by virus in cancer cell line as measured by TUNEL assay
Immunogenic effectNA
Clinical trialNA
PMID23503473