Detailed description page of Selected OV_ID


OV_2209 details
Primary information
OV_IDOV_2209
Virus Name Herpes simplex virus
StrainHSV-1-G47-delta
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeMutant for Gamma34.5, ICP6 and alpha47 gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineHongkong university
Origin of cell lineHuman nasopharyngeal carcinoma cell line
Cell lineCNE-2
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBalb/c nude mice xenograft for CNE-2 cell line (1 × 10⁶ cells)
In-vivo virus concentration2 × 10⁷ pfu
In-vivo toxicityNA
In-vivo resultVirus treated mice shows complete regression in tumor and exhibit longer survival time
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID22059912