| Primary information |
|---|
| OV_ID | OV_602 |
| Virus Name | Alphavirus |
| Strain | M1 |
| Virus type | RNA |
| Virus family | Togaviridae |
| Modification in virus genome | None |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Viral strain in combination with H89 (10 mg/kg/d), injected intraperitoneally |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Female BALB/c-nu/nu mice inoculated subcutaneously with HCT-116, 5x10ⶠcells/mouse |
| In-vivo virus concentration | 3×10ⷠPFU/d |
| In-vivo toxicity | NA |
| In-vivo result | Reduction in tumor volume to 0.2 cubic centimeter compared to control 1cubic centimeter after 27 days |
| Mode of delivery | intravenously |
| Pathway induction | Activates Caspase-3 |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 27374176 |