Detailed description page of Selected OV_ID


OV_2252 details
Primary information
OV_IDOV_2252
Virus Name Herpes simplex virus
StrainHSV-1-G47-delta
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeMutant for Gamma34.5, ICP6 and alpha47 gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineState key laboratory of oncology China
Origin of cell lineHuman breast cancer cell line
Cell lineMDA-MB-435
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice xenograft for MDA-MB-435(1 × 10⁶)
In-vivo virus concentration2 × 10⁷ pfu
In-vivo toxicityNA
In-vivo resultTumor volume decreased by 9 fold after 56 days
Mode of deliveryIntratumoral
Pathway inductionCaspase activation
Immunogenic effectNA
Clinical trialNA
PMID22108767