The total number of records retrieved from this search are 100. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_192	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Female athymic nu/nu mice injected intracranially with GBM30 cells 1.0E+5 cells	5.0E+5 PFU (on 5 day) in total 8 mice	NA	40% mice survived on 28th day	Intratumorally	NA	NA	NA	26524593
OV_193	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubastatin A (TA) at a dose of 1.3 mg per kg body weight (4, 5, 6, 7 and 8 days after tumor implantation)	No	NA	NA	NA	NA	NA	NA	NA	NA	Female athymic nu/nu mice injected intracranially with GBM30 cells 1.0E+5 cells	5.0E+5 PFU (on 5 day) in total 8 mice	NA	80% mice survived on 28th day	Intratumorally	NA	NA	NA	26524593
OV_357	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic BALB/c nu/nu male mice (subcutaneously injected A549 lung cancer cells, 5.0E+6 cells)	1.0E+9 pfu (every 3 days for at total 4 treatments)	NA	41% smaller tumor size compared to the negative control virus AdLacZ	Intratumorally	NA	NA	NA	26561948
OV_358	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	No	Virus in combination with temozolomide (TMZ) intraperitoneally at 50 mg/Kg for five consecutive days	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic BALB/c nu/nu male mice (subcutaneously injected A549 lung cancer cells, 5.0E+6 cells)	1.0E+9 pfu (every 3 days for at total 4 treatments)	NA	70% smaller tumor size compared to the negative control virus AdLacZ	Intratumorally	JNK activation induces autophagy	NA	NA	26561948
OV_359	Adenovirus	AdLacZ	DNA	Adenoviridae	E1/E3-deleted mutant	No	Virus in combination with temozolomide (TMZ) intraperitoneally at 50 mg/Kg for five consecutive days	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic BALB/c nu/nu male mice (subcutaneously injected A549 lung cancer cells, 5.0E+6 cells)	1.0E+9 pfu (every 3 days for at total 4 treatments)	NA	30% smaller tumor size compared to the negative control virus AdLacZ	Intratumorally	JNK activation induces autophagy	NA	NA	26561948
OV_376	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice (subcutaneously xenografted with CHLA-20)	1.0E+7 pfu in 100 μL (on days 0, 2 and 4 after the tumor mass reached 150–300 mm³)	NA	42% mice survived	Intratumorally	NA	NA	NA	26583803
OV_377	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice (subcutaneously xenografted with CHP-123)	1.0E+7 pfu in 100 μL (on days 0, 2 and 4 after the tumor mass reached 150–300 mm³)	NA	63% mice survived	Intratumorally	NA	NA	NA	26583803
OV_378	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice (subcutaneously xenografted with SK-N-AS)	1.0E+7 pfu in 100 μL (on days 0, 2 and 4 after the tumor mass reached 150–300 mm³)	NA	0% mice survived	Intratumorally	NA	NA	NA	26583803
OV_379	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice (subcutaneously xenografted with SK-N-BE(2))	1.0E+7 pfu in 100 μL (on days 0, 2 and 4 after the tumor mass reached 150–300 mm³)	NA	18% mice survived	Intratumorally	NA	NA	NA	26583803
OV_392	Vaccinia virus	GLV-1h68	DNA	Poxviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Homozygous athymic female nude mice (subcutaneously injected with KMC-1 cells suspended in 50 μl Matrigel)	1.0E+7 PFU	NA	Reduction in tumor volume to 30 cubic millimeter compared to control 200 cubic millimeter after 15 days	Intratumorally	NA	NA	NA	26584530
OV_749	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	HepG2 orthotopic liver xenograft tumor in Balb/c athymic nude	NA	NA	Reduction in tumor weight to 0.2 g compared to control 0.75 g after 18 days	intravenously	NA	NA	NA	27450327
OV_750	Adenovirus	AdAFPp-E1A-122	DNA	Adenoviridae	The viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	HepG2 orthotopic liver xenograft tumor in Balb/c athymic nude	NA	NA	Reduction in tumor weight to 0.2 g compared to control 0.75 g after 18 days	intravenously	NA	NA	NA	27450327
OV_751	Adenovirus	AdTrack	DNA	Adenoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	HepG2 orthotopic liver xenograft tumor in Balb/c athymic nude	NA	NA	Reduction in tumor weight to 0.85 g compared to control 0.75 g after 18 days	intravenously	NA	NA	NA	27450327
OV_752	Adenovirus	AdAFPp-E1A-122	DNA	Adenoviridae	The viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	HepG2 subcutaneous liver xenograft tumor in Balb/c athymic nude	NA	NA	Reduction in tumor volume to 0.8 cubic centimeter compared to control 2.4 cubic centimeter after 15 days	intravenously	NA	NA	NA	27450327
OV_838	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant of both copies of gamma 34.5 gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic rat xenograft model for C85 cell line	1.0E+7 pfu	NA	No response	Direct injection	NA	NA	NA	10428757
OV_839	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant of both copies of gamma 34.5 gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic rat xenograft model for C86 cell line	1.0E+7 pfu	NA	4 xenograft model shows partial reduction and 2 shows complete reduction (50% reduction)	Direct injection	NA	NA	NA	10428757
OV_840	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant of both copies of gamma 34.5 gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic rat xenograft model for HCT8 cell line	1.0E+7 pfu	NA	4 xenograft model shows complete reduction and 4 shows partial reduction (complete reduction)	Direct injection	NA	NA	NA	10428757
OV_858	Measles virus	MV-Edm	RNA	Paramyxoviridae	Recombinant expressing a peptide	Yes	No	virus expressing a marker peptide (MV-hCEA)	Natural	NA	NA	NA	NA	NA	NA	NA	Female athymic mouse xenograft model for SKOV3 cell line	1.0E+7 pfu/ml	NA	Median survival time increased by >105 days	subcutaneous	NA	NA	NA	12183422
OV_859	Measles virus	MV-Edm	RNA	Paramyxoviridae	Recombinant expressing a peptide	Yes	No	virus expressing a marker peptide (MV-hCEA)	Natural	NA	NA	NA	NA	NA	NA	NA	Female athymic mouse xenograft model for SKOV3 cell line	10⁷pfu/ml	NA	Median survival time increased by >80 days	intraperitonial	NA	NA	NA	12183422
OV_897	Herpes simplex virus	Mutant	DNA	Herpesviridae	Deletion mutant for Gamma 34.5	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	Hsd athymic nude mice xenograft for Hep 3B cancer cell line	1.0E+7 pfu	NA	Complete reduction in tumor nodes after 4 weeks	intraperitonial	NA	NA	NA	12788648
OV_1103	Adenovirus	ZD55-IL-24	DNA	Adenoviridae	Adenovirus expressing ZD55 gene and IL-24 gene	Yes	No	Expressing IL-24 gene	Shanghai cell collection	NA	NA	NA	NA	NA	NA	NA	Athymic BALB/c nude mice xenograft for SW620 cell line	5.0E+8 cells per well	NA	Decrease in tumor volume below 800mm³ as compared to control	Intratumoral injection	Apoptosis induction and cspase 3 activation	NA	NA	15661558
OV_1104	Adenovirus	Ad-IL-24	DNA	Adenoviridae	Adenovirus expressing IL-24 gene	Yes	No	Expressing IL-24 gene	Shanghai cell collection	NA	NA	NA	NA	NA	NA	NA	Athymic BALB/c nude mice xenograft for SW620 cell line	5.0E+8 cells per well	NA	Decrease in tumor volume below 600mm³ as compared to control	Intratumoral injection	Apoptosis induction and cspase 3 activation	NA	NA	15661558
OV_1105	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	Shanghai cell collection	NA	NA	NA	NA	NA	NA	NA	Athymic BALB/c nude mice xenograft for SW620 cell line	5.0E+8 cells per well	NA	Complete reduction in tumor volume	Intratumoral injection	Apoptosis induction and cspase 3 activation	NA	NA	15661558
OV_1190	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with RAD001 drug (5mg/kg for 5 days)	No	ATCC	Human glioblastoma cell line	U-87 MG	NA	NA	NA	NA	NA	Athymic nude mice xenograft for U87MG cells	1.0E+7 pfu	NA	Complete reduction of tumor after 90 days in 20-40% of animals	NA	NA	NA	NA	17557108
OV_1191	Adenovirus	ICOVIR-5	DNA	Adenoviridae	None	No	ICOVIR-5 in combination with Temozolomide drug (7.5mg/kg for 5 days)	No	ATCC	Human glioblastoma cell line	U-87 MG	NA	NA	NA	NA	NA	Athymic nude mice xenograft for U87MG cells	1.0E+7 pfu	NA	Complete reduction of tumor after 90 days in 20-40% of animals	NA	NA	NA	NA	17557108
OV_1665	Herpes simplex virus	HSV-1	DNA	Herpesviridae	None	Yes	No	Virus expressing vstat120 gene	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice, injected with U87deltaEGFR cell line	1.0E+5 pfu	NA	Significant increase in median survival time of mice	Intracranial	NA	NA	NA	19844198
OV_1666	Herpes simplex virus	HSV-1	DNA	Herpesviridae	None	Yes	No	Virus expressing vstat120 gene	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice, injected with GlideltaEGFR-H2B-RFP cell line	1.5E+6 cells	NA	Significant reduction in tumor volume and increase in median survival time of mice	Subcutaneously	NA	NA	NA	19844198
OV_1915	Vaccinia virus	GLV-1h68	DNA	Poxviridae	None	Yes	No	No	ATCC	Malignan small cell canine carcinoma cell line	MTH52c	NA	NA	NA	NA	NA	Hsd athymic nude mice xenograft for MTH52c cell line	5.0E+6 pfu	NA	Significant decrease in tumor volume after 42 days	NA	NA	Virus cause increase expression of ApoA1, IL-2,11,18,IFN-gamma, IP-10, MCP-1,3,5,MIP-2,MMP-9 and TNF alpha	NA	20631910
OV_2063	Vaccinia virus	GLV-1h68	DNA	Poxviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	PLC	NA	NA	NA	NA	NA	Athymic hsd nude mice xenograft for PLC cell line	5.0E+6 pfu	Reduction in tumor volume below 2000mm compared to control after 45 days	No response	NA	Induction of apoptosis in cancer cell line	Increased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	NA	21779374
OV_2064	Vaccinia virus	GLV-1h68	DNA	Poxviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	NA	NA	NA	Athymic hsd nude mice xenograft for PLC cell line	5.0E+6 pfu	Reduction in tumor volume below 3000mm compared to control after 35 days		NA	Induction of apoptosis in cancer cell line	Increased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	NA	21779374
OV_2408	Vesicular stomatitis virus	VSV-Delta-M51-GFP	RNA	Rhabdoviridae	Deletion of M51 gene and insertion of GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	MIAPaCa-2	NA	NA	NA	NA	NA	Athymic mice xenograft for MIA PaCa2 cell line	5.0E+7 pfu	NA	Reduction in tumor weight below 5 mg after 25 days	Intratumoral	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2409	Vesicular stomatitis virus	VSV-Delta-M51-GFP	RNA	Rhabdoviridae	Deletion of M51 gene and insertion of GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	PANC-1	NA	NA	NA	NA	NA	Athymic mice xenograft for MIA PANC-1 cell line	5 × 10⁷ pfu	NA	Reduction in tumor weight below 200 mg after 25 days	Intratumoral	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2410	Vesicular stomatitis virus	VSV-Delta-M51-GFP	RNA	Rhabdoviridae	Deletion of M51 gene and insertion of GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	HPAF-II	NA	NA	NA	NA	NA	Athymic mice xenograft for HPAF-II cell line	5 × 10⁷ pfu	NA	Reduction in tumor weight below 20 mg after 25 days	Intratumoral	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2411	Vesicular stomatitis virus	VSV-Delta-M51-GFP	RNA	Rhabdoviridae	Deletion of M51 gene and insertion of GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	SU.86.86	NA	NA	NA	NA	NA	Athymic mice xenograft for U.86.86 cell line	5 × 10⁷ pfu	NA	Reduction in tumor weight below 20 mg after 25 days	Intratumoral	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2526	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human pancreatic cancer cell line	PANC-1	NA	NA	NA	NA	NA	Hsd:athymic nude mice xenografted for PANC-1 cell line(2.0E+6 cells)	2.0E+6 pfu	NA	Decrease in tumor volume below 2 after 34 days	Intratumoral	NA	NA	NA	22258815
OV_2527	Vaccinia virus	GLV-1h151	DNA	Poxviridae	Deteltion of TK gene and addition of GFP gene	Yes	No	No	ATCC	Human pancreatic cancer cell line	PANC-1	NA	NA	NA	NA	NA	Hsd:athymic nude mice xenografted for PANC-1 cell line(2.0E+6 cells)	2.0E+6 pfu	NA	Decrease in tumor volume below 2 after 34 days	Intravenous	NA	NA	NA	22258815
OV_2843	Vaccinia virus	wild type	DNA	Poxviridae	None	Yes	No	No	ATCC	Human colorectal cancer cell line	HCT-116	NA	NA	NA	NA	NA	Hsd:athymic nude mice xenograft for HCT-116 (5.0E+6 cells)	5.0E+6 pfu	NA	Significant reduction in tumor volume after 42 days	Intratumoral	NA	NA	NA	23531320
OV_3002	Poxvirus	CF33-hNIS	DNA	Poxviridae	Insertion of gene encoding human hNIS	Yes	No	No	ATCC	Human colorectal cancer cell line	HCT-116	NA	NA	NA	NA	NA	Hsd:athymic nude mice xenograft for HCT-116 (2.0E+6 cells)	1.0E+5 pfu	NA	Complete regression in tumor volume after 55 days	Intratumoral	Immunogenicity followed by virus induced cell death	NA	NA	31061881
OV_3003	Poxvirus	CF33-hNIS	DNA	Poxviridae	Insertion of gene encoding human hNIS	Yes	No	No	ATCC	Human colorectal cancer cell line	HT-29	NA	NA	NA	NA	NA	Hsd:athymic nude mice xenograft for HT-29 (5.0E+6 cells)	1.0E+5 pfu	NA	Tumor volume reached 1500mm after day 50	Intratumoral	Immunogenicity followed by virus induced cell death	NA	NA	31061881
OV_3004	Poxvirus	CF33-hNIS	DNA	Poxviridae	Insertion of gene encoding human hNIS	No	Virus in combination with I-131	No	ATCC	Human colorectal cancer cell line	HCT-116	NA	NA	NA	NA	NA	Hsd:athymic nude mice xenograft for HCT-116 (2.0E+6 cells)	1.0E+4 pfu	NA	Reduction in tumor volume below 100mm after 55 days	Intravenous	Immunogenicity followed by virus induced cell death	NA	NA	31061881
OV_3005	Poxvirus	CF33-hNIS	DNA	Poxviridae	Insertion of gene encoding human hNIS	No	Virus in combination with I-131	No	ATCC	Human colorectal cancer cell line	HT-29	NA	NA	NA	NA	NA	Hsd:athymic nude mice xenograft for HT-29 (3.0E+9 cells)	1.0E+4 pfu	NA	Reduction in tumor volume below 300mm after 45 days	Intravenous	Immunogenicity followed by virus induced cell death	NA	NA	31061881
OV_4108	Vaccinia virus	VVstrain LIVP 6.1.1	DNA	Poxviridae	Mutant for J2R gene	Yes	No	No	University of colorado, USA	NA	NA	NA	NA	NA	NA	NA	Hsd athymic nude mice xenograft for STSA-1 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume reduced to 1000 mm compared to control 2500mm after 42 days	Intravenous	NA	NA	NA	26205404
OV_4109	Vaccinia virus	VVstrain GLV-5b451	DNA	Poxviridae	Derived from LIVP6.1.1 by inserting glaf-2 gene into J2R locus	Yes	No	No	University of colorado, USA	NA	NA	NA	NA	NA	NA	NA	Hsd athymic nude mice xenograft for STSA-1 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume reduced to 200 mm compared to control 2500mm after 49 days	Intravenous	NA	NA	NA	26205404
OV_4148	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with gemcitabine (160mg/kg)	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice xenograft for BxPC-3 (5.0E+5)	5.0E+10 VP per cell	NA	Median survival time increased from 22 days to 57 days with combined tretament	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4149	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with gemcitabine (160mg/kg)	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice xenograft for PANC-1 (5.0E+5)	5.0E+10 VP per cell	NA	Median survival time increased from 37 days to 79.5 days with combined tretament	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4190	Measles virus	MV-lambda-NAP	RNA	Paramyxoviridae	Genetically engineered for expressing human lambda immunoglobulin chain	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Female athymic nude mice xenograft for MDA-231-lu-P4 (1.0E+6 cells)	2.0E+6 TCID50	NA	All mice dead after 100 days	Intravenous	Virus induce apoptosis process leads to cancer cell death	Virus and drug both cause induction of IL-24 expression	In clinical trials	26272026
OV_4191	Measles virus	MV-lambda-NAP	RNA	Paramyxoviridae	Genetically engineered for expressing human lambda immunoglobulin chain	No	Virus in combination with Alisertib 30mg/kg for 3 weeks	No	NA	NA	NA	NA	NA	NA	NA	NA	Female athymic nude mice xenograft for MDA-231-lu-P4 (1.0E+6 cells)	2.0E+6 TCID50	NA	Mice median survival time increased to 82.5 days compared to control	Intravenous	Virus induce apoptosis process leads to cancer cell death	Virus and drug both cause induction of IL-24 expression	In clinical trials	26272026
OV_4192	Measles virus	MV-lambda-NAP	RNA	Paramyxoviridae	Genetically engineered for expressing human lambda immunoglobulin chain	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Female athymic nude mice xenograft for MDA-231-lu-P4 (2.0E+6), pleural effusion transthoracic cavity	5.0E+5 TCID50	NA	Mice median survival increased to 57 days	Transthoracic	Virus induce apoptosis process leads to cancer cell death	Virus and drug both cause induction of IL-24 expression	In clinical trials	26272026
OV_4193	Measles virus	MV-lambda-NAP	RNA	Paramyxoviridae	Genetically engineered for expressing human lambda immunoglobulin chain	Yes	Virus in combination with Alisertib 30mg/kg for 3 weeks	No	NA	NA	NA	NA	NA	NA	NA	NA	Female athymic nude mice xenograft for MDA-231-lu-P4 (2.0E+6), pleural effusion transthoracic cavity	5.0E+5 TCID50	NA	Mice median survival increased to 74 days compared to control 57 days	Transthoracic	Virus induce apoptosis process leads to cancer cell death	Virus and drug both cause induction of IL-24 expression	In clinical trials	26272026
OV_4438	Vesicular stomatitis virus	RdB	RNA	Rhabdoviridae	Virus expressing VSVG epitope, with no dletion in HI-loop, no addition of linker	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	male athymic nude mice xenograft for A549 (1.0E+7)	5.0E+9 pfu	NA	Tumor volume become below 600 cubic millimeter after 71 days compared to control 1000	Intratumoral	NA	NA	NA	26430798
OV_4439	Vesicular stomatitis virus	RdB-1L-VSVG	RNA	Rhabdoviridae	Virus expressing VSVG epitope, with no dletion in HI-loop, addition of single linker	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	male athymic nude mice xenograft for A549 (1.0E+7)	5.0E+9 pfu	NA	Tumor volume become below 100 cubic millimeter after 71 days compared to control 1000	Intratumoral	NA	NA	NA	26430798
OV_4440	Vesicular stomatitis virus	RdB	RNA	Rhabdoviridae	Virus expressing VSVG epitope, with no dletion in HI-loop, no addition of linker	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	male athymic nude mice xenograft for MCF7 (1.0E+7)	5.0E+10 pfu	NA	Tumor volume become below 1500 cubic millimeter after 49 days compared to control 4000	Intratumoral	NA	NA	NA	26430798
OV_4441	Vesicular stomatitis virus	RdB-1L-VSVG	RNA	Rhabdoviridae	Virus expressing VSVG epitope, with no dletion in HI-loop, addition of single linker	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	male athymic nude mice xenograft for MCF7 (1.0E+7)	5.0E+10 pfu	NA	Tumor volume become below 600 cubic millimeter after 49 days compared to control 4000	Intratumoral	NA	NA	NA	26430798
OV_4505	Newcastle disease virus	wild type	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice xenograft for HT1080 (5.0E+6)	2.0E+7 pfu	NA	Tumor volume reduced to 300 cubic mm after 25 days compared to control 800 cubic mm	Intratumoral	NA	Induced expression of Type 1 IFN, NK cells and macrophages	NA	27009956
OV_4506	Newcastle disease virus	73T-S-Km	RNA	Paramyxoviridae	Insertion of HNKMKS sequence in fusogenic site between 111 -116 nucleotide	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice xenograft for HT1080 (5.0E+6)	2.0E+7 pfu	NA	Tumor volume reduced to below 100 cubic mm after 25 days compared to control 800 cubic mm	Intratumoral	NA	Induced expression of Type 1 IFN, NK cells and macrophages	NA	27009956
OV_4507	Newcastle disease virus	73T-R-198	RNA	Paramyxoviridae	Insertion of HNRTKR sequence in fusogenic site between 111 -116 nucleotide	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice xenograft for HT1080 (5.0E+6)	2.0E+7 pfu	NA	Tumor volume reduced to 300 cubic mm after 25 days compared to control 800 cubic mm	Intratumoral	NA	Induced expression of Type 1 IFN, NK cells and macrophages	NA	27009956
OV_4508	Newcastle disease virus	73T-R-198	RNA	Paramyxoviridae	Insertion of HNRTKR sequence in fusogenic site between 111 -116 nucleotide	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice xenograft for HT1080 (5.0E+6)	1.0E+8 pfu	NA	Tumor volume reduced to below 500 cubic mm compared to control 1000 cubic mm after 25 days	Intravenous	NA	Induced expression of Type 1 IFN, NK cells and macrophages	NA	27009956
OV_4631	Adenovirus	Ad5/3-delata 24	DNA	Adenoviridae	Mutation in delta E3 and delta 24 gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Female athymic nude mice xenograft for UPCI SCC 090 (2.0E+6)	3.5E+11 pfu	NA	Complete ereduction in tumor volume after 30 days	Intratumoral	NA	NA	NA	27086483
OV_4632	Adenovirus	Ad5/3-CB016	DNA	Adenoviridae	Mutation in delta E3 gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Female athymic nude mice xenograft for UPCI SCC 090 (2.0E+6)	3.5E+11 pfu	NA	Complete ereduction in tumor volume after 30 days	Intratumoral	NA	NA	NA	27086483
OV_4698	Herpes simplex virus	RAMBO	DNA	Herpesviridae	Antiangiogenic Vstat120 expressing virus	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice subcutaneous xenograft for CAL27 (1.5E+7)	2.0E+6 pfu on day 7 and 16	NA	Mice treated with virus shows delayed tumor growth compared to control, one shows complete tumor regression	Intratumoral	NA	Induce antitumor immune response	NA	27119105
OV_4704	Herpes simplex virus	RAMBO	DNA	Herpesviridae	Antiangiogenic Vstat120 expressing virus	No	Virus combination with ATN-224 (0.7 mg/kg/day) an copper chelator showing synergistic effect	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice xenograft for UM-SCC-74A (1.5E+7)	2.0E+6 pfu on day 7	NA	Increased in survival time and reduction in tumor volume to below 200 cubic mm comapred to control 700 cubic mm	Intratumoral	NA	Induce antitumor immune response	NA	27119105
OV_4705	Herpes simplex virus	RAMBO	DNA	Herpesviridae	Antiangiogenic Vstat120 expressing virus	No	Virus combination with ATN-224 (0.7 mg/kg/day) an copper chelator showing synergistic effect	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice xenograft for CAL27 (1.5E+7)	2.0E+6 pfu on day 7	NA	Increased in survival time and reduction in tumor volume to below 500 cubic mm comapred to control 2000 cubic mm	Intratumoral	NA	Induce antitumor immune response	NA	27119105
OV_5184	Tanapoxvirus	wild type	DNA	Poxviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice CrlNU-Foxn1 xenograft for cellosaurus cell line 5.0E+6 cells	5.0E+6 pfu	NA	Reduction in tumor growth 250 compared to 550 after 34 days	Intratumoral	NA	NA	NA	27738905
OV_5185	Tanapoxvirus	TPV-delta15L	DNA	Poxviridae	Deletion mutant for 15L gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice CrlNU-Foxn1 xenograft for cellosaurus cell line 5.0E+6 cells	5.0E+6 pfu	NA	Complete regression in tumor volume compared to 550 after 34 days	Intratumoral	NA	NA	NA	27738905
OV_5186	Tanapoxvirus	TPV-delta66R	DNA	Poxviridae	Deletion mutant for tk 66ORF	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice CrlNU-Foxn1 xenograft for cellosaurus cell line 5.0E+6 cells	5.0E+6 pfu	NA	Reduction in tumor growth 150 compared to 550 after 34 days	Intratumoral	NA	NA	NA	27738905
OV_5187	Tanapoxvirus	TPV-delta15Ldelta66R	DNA	Poxviridae	Deletion mutant for 15L gene and tk 66R locus	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice CrlNU-Foxn1 xenograft for cellosaurus cell line 5.0E+6 cells	5.0E+6 pfu	NA	Reduction in tumor growth 200 compared to 550 after 34 days	Intratumoral	NA	NA	NA	27738905
OV_5638	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for human fibroblast HT1080 (10 million)	3.0E+8 pfu	NA	Complete regrression in tumor in 11 mice from complete 12 (tumor volume <10mm and >5 mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5639	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for human fibroblast HT1080 (10 million)	3.0E+8 pfu	NA	Complete regrression in tumor in 8 mice from complete 9 (tumor volume <10mm and >5 mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5640	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for human fibroblast HT1080 (10 million)	3.0E+8 pfu	NA	Complete regrression in tumor in all mice (tumor volume <10mm and >5 mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5641	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for human ovarian carcinoma PA-1 (10 million)	3.0E+8 pfu	NA	Complete regrression in tumor in all mice (tumor volume <10mm and >5 mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5642	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for human oral carcinoma KB (10 million)	3.0E+8 pfu	NA	Complete reduction in tumor in 7 mice from all 12 treated (tumor volume <10mm and >5 mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5643	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for human fmelanoma SKMEL (10 million)	3.0E+8 pfu	NA	Complete reduction in tumor in 5 mice from all 8 treated (tumor volume <10mm and >5 mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5644	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for human lung carcinoma A375 (10 million)	3.0E+8 pfu	NA	Complete reduction in tumor in 5 mice from all 8 treated (tumor volume <10mm and >5 mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5645	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for human lung carcinoma A375 (10 million)	3.0E+8 pfu	NA	Complete regrression in tumor in all mice (tumor volume <10mm and >5 mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5646	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for humanglioblastoma U87MG (10 million)	3.0E+8 pfu	NA	Complete reduction in tumor in 1 mice from all 9 treated (tumor volume <10mm and >5 mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5647	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for human fibroblast HT1080 (10 million)	1.0E+9 pfu	NA	Complete regression in all tumor bearing mice (tumor volume <8.5 mm and > 5.5)	Intravenously	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5648	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for human fibroblast HT1080 (10 million)	3.0E+8 pfu	NA	Complete regression in all tumor bearing mice (tumor volume <8.5 mm and > 5.5)	Intravenously	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5649	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for human fibroblast HT1080 (10 million)	6.0E+7 pfu	NA	Complete regression in tumor volume in 10 mice out of 11 (tumor volume <8.5 mm and > 5.5)	Intravenously	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5650	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for human fibroblast HT1080 (10 million)	2.0E+7 pfu	NA	Complete regression in tumor volume in 5 mice out of 11 (tumor volume <8.5 mm and > 5.5)	Intravenously	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5651	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for human fibroblast HT1080 (10 million)	2.0E+7 pfu	NA	Complete regression in tumor volume in 5 mice out of 7 (tumor volume <8.5 mm and > 5.5)	Intravenously	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5652	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for A375 (10 million)	1.5E+9 pfu	NA	Complete regression in tumor in 2 mice from total 8 tretated (tumor dimension 8 - 9.5mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5653	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for A375 (10 million)	9.0E+8 pfu	NA	Complete regression in tumor in 7 mice from total 8 tretated (tumor dimension 8 - 9.5mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5654	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for A375 (10 million)	3.0E+8 pfu	NA	Complete regression in tumor in 3 mice from total 8 tretated (tumor dimension 8 - 9.5mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5655	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for A375 (10 million)	1.5E+9 pfu	NA	Complete regression in tumor in 2 mice from total 6 tretated (tumor volume <300mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5656	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for A375 (10 million)	9.0E+8 pfu	NA	Complete regression in tumor in 3 mice from total 4 tretated (tumor dimension <300mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5657	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for A375 (10 million)	3.0E+8 pfu	NA	Complete regression in tumor in 2 mice from total 6 tretated (tumor volume <300mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5658	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for A375 (10 million)	3.0E+8 pfu	NA	Complete regression in tumor in 3 mice from total 5 tretated (tumor volume >300mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5659	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for A375 (10 million)	3.0E+8 pfu	NA	Complete regression in tumor in all mice(tumor volume >300mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5660	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for A375 (10 million)	3.0E+8 pfu	NA	Complete regression in tumor in 4 mice from total 5 tretated (tumor volume>300mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5661	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for A375 (10 million)	1.5E+9 pfu	NA	Complete regression in tumor in all mice (tumor dimension 10 - 11.5 mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5662	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for A375 (10 million)	3.0E+8 pfu	NA	Complete regression in tumor in 6 mice from 7 (tumor dimension 10 - 11.5 mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5663	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for A375 (10 million)	3.0E+7 pfu	NA	Complete regression in tumor in 5 mice from 7 (tumor dimension 10 - 11.5 mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5664	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for A375 (10 million)	3.0E+6 pfu	NA	Complete regression in tumor in 5 mice from 7 (tumor dimension 10 - 11.5 mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5665	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for A375 (10 million)	1.5E+9 pfu	NA	Complete regression in tumor in all mice (tumor volume >300mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5666	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for A375 (10 million)	3.0E+8 pfu	NA	Complete reduction in tumor in 6 mice from 7 (tumor volume >300mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5667	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for A375 (10 million)	3.0E+7 pfu	NA	Complete reduction in tumor in 4 mice from 6 (tumor volume >300mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5668	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic mice xenograft for A375 (10 million)	3.0E+6 pfu	NA	Complete reduction in tumor in 4 mice from 6 (tumor volume >300mm)	Intratumoral	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5682	Vaccinia virus	GLV-1h22	DNA	Poxviridae	Insertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectively	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Hsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)	5.0E+6 pfu	NA	Tumor volume become 261.8mm compared to control 240.8 mm after 33 days	Intravenously	Induction of apoptosis	NA	NA	US8052968
OV_5683	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectively	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Hsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)	5.0E+6 pfu	NA	Tumor volume become 248.4mm compared to control 240.8 mm after 33 days	Intravenously	Induction of apoptosis	NA	NA	US8052968
OV_5684	Vaccinia virus	GLV-1h70	DNA	Poxviridae	Insertion of Ruc-GFP, LacZ gene locus and TK and HA gene locus using psel vectorrespectively	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Hsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)	5.0E+6 pfu	NA	Tumor volume become 216.8mm compared to control 240.8 mm after 33 days	Intravenously	Induction of apoptosis	NA	NA	US8052968