Detailed description page of Selected OV_ID


OV_2527 details
Primary information
OV_IDOV_2527
Virus Name Vaccinia virus
StrainGLV-1h151
Virus typeDNA
Virus familyPoxviridae
Modification in virus genomeDeteltion of TK gene and addition of GFP gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman pancreatic cancer cell line
Cell linePANC-1
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismHsd:athymic nude mice xenografted for PANC-1 cell line(2 × 10⁶ cells)
In-vivo virus concentration2 × 10⁶ pfu
In-vivo toxicityNA
In-vivo resultDecrease in tumor volume below 2 after 34 days
Mode of deliveryIntravenous
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID22258815