Detailed description page of Selected OV_ID


OV_4506 details
Primary information
OV_IDOV_4506
Virus Name Newcastle disease virus
Strain73T-S-Km
Virus typeRNA
Virus familyParamyxoviridae
Modification in virus genomeInsertion of HNKMKS sequence in fusogenic site between 111 -116 nucleotide
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismAthymic nude mice xenograft for HT1080 (5 × 10⁶)
In-vivo virus concentration2 × 10⁷ pfu
In-vivo toxicityNA
In-vivo resultTumor volume reduced to below 100 cubic mm after 25 days compared to control 800 cubic mm
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectInduced expression of Type 1 IFN, NK cells and macrophages
Clinical trialNA
PMID27009956