Detailed description page of Selected OV_ID


OV_1666 details
Primary information
OV_IDOV_1666
Virus Name Herpes simplex virus
StrainHSV-1
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeNone
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeVirus expressing vstat120 gene
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismAthymic nude mice, injected with GlideltaEGFR-H2B-RFP cell line
In-vivo virus concentration1.5 × 10⁶ cells
In-vivo toxicityNA
In-vivo resultSignificant reduction in tumor volume and increase in median survival time of mice
Mode of deliverySubcutaneously
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID19844198