Detailed description page of Selected OV_ID


OV_2063 details
Primary information
OV_IDOV_2063
Virus Name Vaccinia virus
StrainGLV-1h68
Virus typeDNA
Virus familyPoxviridae
Modification in virus genomeNone
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman hepatocellular carcinoma cell line
Cell linePLC
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismAthymic hsd nude mice xenograft for PLC cell line
In-vivo virus concentration5 × 10⁶ pfu
In-vivo toxicityReduction in tumor volume below 2000mm compared to control after 45 days
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionInduction of apoptosis in cancer cell line
Immunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2
Clinical trialNA
PMID21779374