Detailed description page of Selected OV_ID


OV_192 details
Primary information
OV_IDOV_192
Virus Name Herpes simplex virus
StrainrQNestin34.5
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeDeletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismFemale athymic nu/nu mice injected intracranially with GBM30 cells (10⁵ cells)
In-vivo virus concentration5 × 10⁵ PFU (on 5 day) in total 8 mice
In-vivo toxicityNA
In-vivo result40% mice survived on 28th day
Mode of deliveryIntratumorally
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID26524593