Detailed description page of Selected OV_ID


OV_3002 details
Primary information
OV_IDOV_3002
Virus Name Poxvirus
StrainCF33-hNIS
Virus typeDNA
Virus familyPoxviridae
Modification in virus genomeInsertion of gene encoding human hNIS
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman colorectal cancer cell line
Cell lineHCT-116
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismHsd:athymic nude mice xenograft for HCT-116 (2 × 10⁶ cells)
In-vivo virus concentration1 × 10⁵ pfu
In-vivo toxicityNA
In-vivo resultComplete regression in tumor volume after 55 days
Mode of deliveryIntratumoral
Pathway inductionImmunogenicity followed by virus induced cell death
Immunogenic effectNA
Clinical trialNA
PMID31061881