Detailed description page of Selected OV_ID


OV_2410 details
Primary information
OV_IDOV_2410
Virus Name Vesicular stomatitis virus
StrainVSV-Delta-M51-GFP
Virus typeRNA
Virus familyRhabdoviridae
Modification in virus genomeDeletion of M51 gene and insertion of GFP gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell linePancreatic ductal adeonocarcinoma cell line
Cell lineHPAF-II
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismAthymic mice xenograft for HPAF-II cell line
In-vivo virus concentration5 × 10⁷ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor weight below 20 mg after 25 days
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectDownregulation of IFN-Gamma
Clinical trialNA
PMID22238308