Detailed description page of Selected OV_ID


OV_4192 details
Primary information
OV_IDOV_4192
Virus Name Measles virus
StrainMV-lambda-NAP
Virus typeRNA
Virus familyParamyxoviridae
Modification in virus genomeGenetically engineered for expressing human lambda immunoglobulin chain
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismFemale athymic nude mice xenograft for MDA-231-lu-P4 (2 × 10⁶), pleural effusion transthoracic cavity
In-vivo virus concentration5 × 10⁵ TCID50
In-vivo toxicityNA
In-vivo resultMice median survival increased to 57 days
Mode of deliveryTransthoracic
Pathway inductionVirus induce apoptosis process leads to cancer cell death
Immunogenic effectVirus and drug both cause induction of IL-24 expression
Clinical trialIn clinical trials
PMID26272026