| Primary information |
|---|
| OV_ID | OV_2411 |
| Virus Name | Vesicular stomatitis virus |
| Strain | VSV-Delta-M51-GFP |
| Virus type | RNA |
| Virus family | Rhabdoviridae |
| Modification in virus genome | Deletion of M51 gene and insertion of GFP gene |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | ATCC |
| Origin of cell line | Pancreatic ductal adeonocarcinoma cell line |
| Cell line | SU.86.86 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Athymic mice xenograft for U.86.86 cell line |
| In-vivo virus concentration | 5 × 10ⷠpfu
|
| In-vivo toxicity | NA |
| In-vivo result | Reduction in tumor weight below 20 mg after 25 days |
| Mode of delivery | Intratumoral |
| Pathway induction | NA |
| Immunogenic effect | Downregulation of IFN-Gamma |
| Clinical trial | NA |
| PMID | 22238308 |