| Primary information |
|---|
| OV_ID | OV_1915 |
| Virus Name | Vaccinia virus |
| Strain | GLV-1h68 |
| Virus type | DNA |
| Virus family | Poxviridae |
| Modification in virus genome | None |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | ATCC |
| Origin of cell line | Malignan small cell canine carcinoma cell line |
| Cell line | MTH52c |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Hsd athymic nude mice xenograft for MTH52c cell line |
| In-vivo virus concentration | 5× 10ⶠpfu
|
| In-vivo toxicity | NA |
| In-vivo result | Significant decrease in tumor volume after 42 days |
| Mode of delivery | NA |
| Pathway induction | NA |
| Immunogenic effect | Virus cause increase expression of ApoA1, IL-2,11,18,IFN-gamma, IP-10, MCP-1,3,5,MIP-2,MMP-9 and TNF alpha |
| Clinical trial | NA |
| PMID | 20631910 |