Detailed description page of Selected OV_ID


OV_1915 details
Primary information
OV_IDOV_1915
Virus Name Vaccinia virus
StrainGLV-1h68
Virus typeDNA
Virus familyPoxviridae
Modification in virus genomeNone
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineMalignan small cell canine carcinoma cell line
Cell lineMTH52c
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismHsd athymic nude mice xenograft for MTH52c cell line
In-vivo virus concentration5× 10⁶ pfu
In-vivo toxicityNA
In-vivo resultSignificant decrease in tumor volume after 42 days
Mode of deliveryNA
Pathway inductionNA
Immunogenic effectVirus cause increase expression of ApoA1, IL-2,11,18,IFN-gamma, IP-10, MCP-1,3,5,MIP-2,MMP-9 and TNF alpha
Clinical trialNA
PMID20631910