Detailed description page of Selected OV_ID


OV_4698 details
Primary information
OV_IDOV_4698
Virus Name Herpes simplex virus
StrainRAMBO
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeAntiangiogenic Vstat120 expressing virus
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismAthymic nude mice subcutaneous xenograft for CAL27 (1.5 × 10⁷)
In-vivo virus concentration2 × 10⁶ pfu on day 7 and 16
In-vivo toxicityNA
In-vivo resultMice treated with virus shows delayed tumor growth compared to control, one shows complete tumor regression
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectInduce antitumor immune response
Clinical trialNA
PMID27119105