Detailed description page of Selected OV_ID


OV_5644 details
Primary information
OV_IDOV_5644
Virus Name Newcastle disease virus
StrainNDV-MK107
Virus typeRNA
Virus familyParamyxoviridae
Modification in virus genomeNone
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismAthymic mice xenograft for human lung carcinoma A375 (10 million)
In-vivo virus concentration3 ×10⁸ pfu
In-vivo toxicityNA
In-vivo resultComplete reduction in tumor in 5 mice from all 8 treated (tumor volume <10mm and >5 mm)
Mode of deliveryIntratumoral
Pathway inductionInduction of apoptosis by virus infection
Immunogenic effectInduction of IFN-Gamma production
Clinical trialNA
PMIDUS7470426