| Primary information |
|---|
| OV_ID | OV_3005 |
| Virus Name | Poxvirus |
| Strain | CF33-hNIS |
| Virus type | DNA |
| Virus family | Poxviridae |
| Modification in virus genome | Insertion of gene encoding human hNIS |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Virus in combination with I-131 |
| Immune gene induction in virus genome | No |
| Source of cell line | ATCC |
| Origin of cell line | Human colorectal cancer cell line |
| Cell line | HT-29 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Hsd:athymic nude mice xenograft for HT-29 (3 × 10⹠cells) |
| In-vivo virus concentration | 1 × 10ⴠpfu
|
| In-vivo toxicity | NA |
| In-vivo result | Reduction in tumor volume below 300mm after 45 days |
| Mode of delivery | Intravenous |
| Pathway induction | Immunogenicity followed by virus induced cell death |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 31061881 |