Detailed description page of Selected OV_ID


OV_4705 details
Primary information
OV_IDOV_4705
Virus Name Herpes simplex virus
StrainRAMBO
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeAntiangiogenic Vstat120 expressing virus
Virus aloneNo
Virus in combination iwth drug/radiationVirus combination with ATN-224 (0.7 mg/kg/day) an copper chelator showing synergistic effect
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismAthymic nude mice xenograft for CAL27 (1.5 × 10⁷)
In-vivo virus concentration2 × 10⁶ pfu on day 7
In-vivo toxicityNA
In-vivo resultIncreased in survival time and reduction in tumor volume to below 500 cubic mm comapred to control 2000 cubic mm
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectInduce antitumor immune response
Clinical trialNA
PMID27119105