Detailed description page of Selected OV_ID


OV_4149 details
Primary information
OV_IDOV_4149
Virus Name Adenovirus
StrainAduPARE1A
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeAddition of E1A gene upstream of uPAR promoter
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with gemcitabine (160mg/kg)
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismAthymic nude mice xenograft for PANC-1 (5 × 10⁵)
In-vivo virus concentration5 × 10¹⁰ vp/cell
In-vivo toxicityNA
In-vivo resultMedian survival time increased from 37 days to 79.5 days with combined tretament
Mode of deliveryNA
Pathway inductionVirus induce apoptosis process leads to cancer cell death
Immunogenic effectNA
Clinical trialNA
PMID26227809