Detailed description page of Selected OV_ID


OV_377 details
Primary information
OV_IDOV_377
Virus Name Herpes simplex virus
StrainSeprehvir (HSV1716)
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeΔγ134.5 attenuated virus mutant
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismAthymic nude mice (subcutaneously xenografted with CHP-123)
In-vivo virus concentration10⁷ pfu in 100 μL (on days 0, 2 and 4 after the tumor mass reached 150–300 mm³)
In-vivo toxicityNA
In-vivo result63% mice survived
Mode of deliveryIntratumorally
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID26583803