Detailed description page of Selected OV_ID


OV_193 details
Primary information
OV_IDOV_193
Virus Name Herpes simplex virus
StrainrQNestin34.5
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeDeletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with tubastatin A (TA) at a dose of 1.3 mg per kg body weight (4, 5, 6, 7 and 8 days after tumor implantation)
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismFemale athymic nu/nu mice injected intracranially with GBM30 cells (10⁵ cells)
In-vivo virus concentration5 × 10⁵ PFU (on 5 day) in total 8 mice
In-vivo toxicityNA
In-vivo result80% mice survived on 28th day
Mode of deliveryIntratumorally
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID26524593