| Primary information |
|---|
| OV_ID | OV_193 |
| Virus Name | Herpes simplex virus |
| Strain | rQNestin34.5 |
| Virus type | DNA |
| Virus family | Herpesviridae |
| Modification in virus genome | Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Virus in combination with tubastatin A (TA) at a dose of 1.3 mg per kg body weight (4, 5, 6, 7 and 8 days after tumor implantation) |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Female athymic nu/nu mice injected intracranially with GBM30 cells (10âµ cells) |
| In-vivo virus concentration | 5 × 10ⵠPFU (on 5 day) in total 8 mice |
| In-vivo toxicity | NA |
| In-vivo result | 80% mice survived on 28th day |
| Mode of delivery | Intratumorally |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 26524593 |