Detailed description page of Selected OV_ID


OV_4193 details
Primary information
OV_IDOV_4193
Virus Name Measles virus
StrainMV-lambda-NAP
Virus typeRNA
Virus familyParamyxoviridae
Modification in virus genomeGenetically engineered for expressing human lambda immunoglobulin chain
Virus aloneYes
Virus in combination iwth drug/radiationVirus in combination with Alisertib 30mg/kg for 3 weeks
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismFemale athymic nude mice xenograft for MDA-231-lu-P4 (2 × 10⁶), pleural effusion transthoracic cavity
In-vivo virus concentration5 × 10⁵ TCID50
In-vivo toxicityNA
In-vivo resultMice median survival increased to 74 days compared to control 57 days
Mode of deliveryTransthoracic
Pathway inductionVirus induce apoptosis process leads to cancer cell death
Immunogenic effectVirus and drug both cause induction of IL-24 expression
Clinical trialIn clinical trials
PMID26272026