| Primary information |
|---|
| OV_ID | OV_376 |
| Virus Name | Herpes simplex virus |
| Strain | Seprehvir (HSV1716) |
| Virus type | DNA |
| Virus family | Herpesviridae |
| Modification in virus genome | Δγ134.5 attenuated virus mutant |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Athymic nude mice (subcutaneously xenografted with CHLA-20) |
| In-vivo virus concentration | 10ⷠpfu in 100 μL (on days 0, 2 and 4 after the tumor mass reached 150–300 mm³) |
| In-vivo toxicity | NA |
| In-vivo result | 42% mice survived |
| Mode of delivery | Intratumorally |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 26583803 |