Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0305	Lipopolysaccharide (LPS) Click for more detail	E. coli 055:B5(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS promotes TGFb1 and VEGF production in human prostate epithelial PC3 cells and also LPS stimulation, leads to the increased expression of NF-KB p65 protein.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Human prostate epithelial PC3 cells	LRR	O00206.fasta	O00206	839	It plays important roles in promoting prostate cancer immune escape, survival, progression, and metastasis by inducing immunosuppressive and proangiogenic cytokines.	ELISA	18649875	2008	Pubchem Assay
PRRID_0305	Lipopolysaccharide (LPS) Click for more detail	E. coli 055:B5(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS promotes TGFb1 and VEGF production in human prostate epithelial PC3 cells and also LPS stimulation, leads to the increased expression of NF-KB p65 protein.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Human prostate epithelial PC3 cells	LRR	O00206.fasta	O00206	839	It plays important roles in promoting prostate cancer immune escape, survival, progression, and metastasis by inducing immunosuppressive and proangiogenic cytokines.	ELISA	18649875	2008	Pubchem Assay
PRRID_0307	Lipopolysaccharide (LPS) Click for more detail	Burkholderia pseudomallei(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Stimulation via LPS leads to the production of TNF-Œ±, MIP-2, and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	HEK293 cells	LRR	Q9QUK6.fasta	Q9QUK6	835	It has a immunostimulatory role	ELISA	18691413	2008	Pubchem Assay
PRRID_0307	Lipopolysaccharide (LPS) Click for more detail	Burkholderia pseudomallei(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Stimulation via LPS leads to the production of TNF-Œ±, MIP-2, and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	HEK293 cells	LRR	Q9QUK6.fasta	Q9QUK6	835	It has a immunostimulatory role	ELISA	18691413	2008	Pubchem Assay
PRRID_0308	Lipopolysaccharide (LPS) Click for more detail	Burkholderia pseudomallei(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Stimulation via LPS leads to the activation of NF-KappaB, which resulted into the production of TNF-Œ±, MIP-2, and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	HEK293 cells	LRR	O00206.fasta	O00206	839	It has a immunostimulatory role	ELISA	18691413	2008	Pubchem Assay
PRRID_0308	Lipopolysaccharide (LPS) Click for more detail	Burkholderia pseudomallei(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Stimulation via LPS leads to the activation of NF-KappaB, which resulted into the production of TNF-Œ±, MIP-2, and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	HEK293 cells	LRR	O00206.fasta	O00206	839	It has a immunostimulatory role	ELISA	18691413	2008	Pubchem Assay
PRRID_0309	Lipopolysaccharide (LPS) Click for more detail	Escherichia coli (055:B5) (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	It leads to the activation of the transcription factor nuclear factor kappa B (NFKB) in caput and cauda epididymides.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Rat	Epididymis	LRR	NA	NA	NA	Rat epididymis is fully capable of initiating an inflammatory response to lipopolysaccharide (LPS) from Escherichia coli through activation of Tolllike receptor 4.	EMSA	18703421	2008	NA
PRRID_0309	Lipopolysaccharide (LPS) Click for more detail	Escherichia coli (055:B5) (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	It leads to the activation of the transcription factor nuclear factor kappa B (NFKB) in caput and cauda epididymides.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Rat	Epididymis	LRR	NA	NA	NA	Rat epididymis is fully capable of initiating an inflammatory response to lipopolysaccharide (LPS) from Escherichia coli through activation of Tolllike receptor 4.	EMSA	18703421	2008	NA
PRRID_0310	Lipopolysaccharide (LPS) Click for more detail	E. coli(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS stimulation leads to the activation of phospholipase C	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages and Dendritic cells	NA	Q9QUK6.fasta	Q9QUK6	835	It has the role in immuno inflammation.	ELISA	18233961	2008	Pubchem Assay
PRRID_0310	Lipopolysaccharide (LPS) Click for more detail	E. coli(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS stimulation leads to the activation of phospholipase C	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages and Dendritic cells	NA	Q9QUK6.fasta	Q9QUK6	835	It has the role in immuno inflammation.	ELISA	18233961	2008	Pubchem Assay
PRRID_0311	Lipoprotein Click for more detail	Ureaplasma parvum (Bacteria)	NA	NA	Lipoprotein	Natural	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leads to the activation of NF-	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	Kidney cell line, 293T	LRR	Q15399.fasta	Q15399	786	This induces the inflammatory response.	ELISA	18451040	2008	Pubchem Assay
PRRID_0311	Lipoprotein Click for more detail	Ureaplasma parvum (Bacteria)	NA	NA	Lipoprotein	Natural	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leads to the activation of NF-	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	Kidney cell line, 293T	LRR	Q15399.fasta	Q15399	786	This induces the inflammatory response.	ELISA	18451040	2008	Pubchem Assay
PRRID_0312	Lipoprotein Click for more detail	Ureaplasma parvum (Bacteria)	NA	NA	Lipoprotein	Natural	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leads to the activation of NF-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Kidney cell line, 293T	LRR	O60603.fasta	O60603	784	This induces the inflammatory response.	ELISA	18451040	2008	Pubchem Assay
PRRID_0312	Lipoprotein Click for more detail	Ureaplasma parvum (Bacteria)	NA	NA	Lipoprotein	Natural	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leads to the activation of NF-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Kidney cell line, 293T	LRR	O60603.fasta	O60603	784	This induces the inflammatory response.	ELISA	18451040	2008	Pubchem Assay
PRRID_0313	Lipoprotein Click for more detail	Ureaplasma parvum (Bacteria)	NA	NA	Lipoprotein	Natural	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leads to the activation of NF-	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Kidney cell line, 293T	LRR	Q9Y2C9.fasta	Q9Y2C9	796	This induces the inflammatory response.	ELISA	18451040	2008	Pubchem Assay
PRRID_0313	Lipoprotein Click for more detail	Ureaplasma parvum (Bacteria)	NA	NA	Lipoprotein	Natural	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leads to the activation of NF-	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Kidney cell line, 293T	LRR	Q9Y2C9.fasta	Q9Y2C9	796	This induces the inflammatory response.	ELISA	18451040	2008	Pubchem Assay
PRRID_0314	Lipoprotein Click for more detail	Listeria monocytogenes (Bacteria)	NA	NA	Lipoprotein	Natural	It leads to the activation of NF-Œ∫B and stimulates the production of proinflammatory cytokines such as TNF-alpha and IL-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Bone marrow-derived DC	NA	Q9QUN7.fasta	Q9QUN7	784	It has a immunostimulatory role	Cytokines assay	18641340	2008	Pubchem Assay
PRRID_0314	Lipoprotein Click for more detail	Listeria monocytogenes (Bacteria)	NA	NA	Lipoprotein	Natural	It leads to the activation of NF-Œ∫B and stimulates the production of proinflammatory cytokines such as TNF-alpha and IL-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Bone marrow-derived DC	NA	Q9QUN7.fasta	Q9QUN7	784	It has a immunostimulatory role	Cytokines assay	18641340	2008	Pubchem Assay
PRRID_0316	Lipoteichoic Acid (LTA) Click for more detail	Bacillus subtilis(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	LTA-treated LEC increases the expression of E-selectin, ICAM-1, and VCAM-1, moreover it induces the expression of CCL2, CCL5, and CCL20 (Cys-Cys motif chemokines) and of CXCL1, CXCL3, CXCL5, CXCL6, and CXCL8 (Cys-X-Cys motif chemokines).	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Cultured human lymphatic endothelium (LEC)	LRR	O60603.fasta	O60603	784	It has a immunostimulatory role	ELISA	18523807	2008	Pubchem Assay
PRRID_0316	Lipoteichoic Acid (LTA) Click for more detail	Bacillus subtilis(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	LTA-treated LEC increases the expression of E-selectin, ICAM-1, and VCAM-1, moreover it induces the expression of CCL2, CCL5, and CCL20 (Cys-Cys motif chemokines) and of CXCL1, CXCL3, CXCL5, CXCL6, and CXCL8 (Cys-X-Cys motif chemokines).	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Cultured human lymphatic endothelium (LEC)	LRR	O60603.fasta	O60603	784	It has a immunostimulatory role	ELISA	18523807	2008	Pubchem Assay
PRRID_0318	Lipoteichoic Acid (LTA) Click for more detail	Enterococcus faecalis (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	Upon exposure to E. faecalis LTA, it produces a high level of tumor necrosis factor-‚ç∫ (TNF-‚ç∫) and nitric oxide (NO).	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	RAW 264.7	NA	Q9QUN7.fasta	Q9QUN7	784	LTA contributes to E. faecalis‚Äìinduced inflammatory responses.	ELISA	18634930	2008	Pubchem Assay
PRRID_0318	Lipoteichoic Acid (LTA) Click for more detail	Enterococcus faecalis (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	Upon exposure to E. faecalis LTA, it produces a high level of tumor necrosis factor-‚ç∫ (TNF-‚ç∫) and nitric oxide (NO).	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	RAW 264.7	NA	Q9QUN7.fasta	Q9QUN7	784	LTA contributes to E. faecalis‚Äìinduced inflammatory responses.	ELISA	18634930	2008	Pubchem Assay
PRRID_0319	Lipoteichoic Acid (LTA) Click for more detail	S. aureus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	LTA induces the Stat1 and Stat3 activation via induction of IRF1/2 and interferon-Œ± production.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macropahges	NA	Q9QUN7.fasta	Q9QUN7	784	It resulted in the antibacterial response.	ELISA	18652890	2008	Pubchem Assay
PRRID_0319	Lipoteichoic Acid (LTA) Click for more detail	S. aureus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	LTA induces the Stat1 and Stat3 activation via induction of IRF1/2 and interferon-Œ± production.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macropahges	NA	Q9QUN7.fasta	Q9QUN7	784	It resulted in the antibacterial response.	ELISA	18652890	2008	Pubchem Assay
PRRID_0320	Low Molecular Weight Hyaluronic Acid (LMW-HA) Click for more detail	Host (Endogenous) (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Glycosaminoglycan	Natural	It leads to the production of antimicrobial peptide beta defensins 2.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Keratinocytes NCTC 2544 cell line	NA	O60603.fasta	O60603	784	It leadsto the induction of an antibacterial response.	ELISA	18641349	2008	Pubchem Assay
PRRID_0320	Low Molecular Weight Hyaluronic Acid (LMW-HA) Click for more detail	Host (Endogenous) (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Glycosaminoglycan	Natural	It leads to the production of antimicrobial peptide beta defensins 2.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Keratinocytes NCTC 2544 cell line	NA	O60603.fasta	O60603	784	It leadsto the induction of an antibacterial response.	ELISA	18641349	2008	Pubchem Assay
PRRID_0321	Low Molecular Weight Hyaluronic Acid (LMW-HA) Click for more detail	Host (Endogenous) (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Glycosaminoglycan	Natural	It leads to the production of antimicrobial peptide beta defensins 2.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Keratinocytes NCTC 2544 cell line	NA	O00206.fasta	O00206	839	It leadsto the induction of an antibacterial response.	ELISA	18641349	2008	Pubchem Assay
PRRID_0321	Low Molecular Weight Hyaluronic Acid (LMW-HA) Click for more detail	Host (Endogenous) (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Glycosaminoglycan	Natural	It leads to the production of antimicrobial peptide beta defensins 2.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Keratinocytes NCTC 2544 cell line	NA	O00206.fasta	O00206	839	It leadsto the induction of an antibacterial response.	ELISA	18641349	2008	Pubchem Assay
PRRID_0322	Low Molecular Weight Hyaluronic Acid (LMW-HA) Click for more detail	Host (Endogenous) (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Glycosaminoglycan	Natural	It leads to the production of antimicrobial peptide beta defensins 2.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Dorsal skin	NA	O00206.fasta	O00206	839	It leadsto the induction of an antibacterial response.	ELISA	18641349	2008	Pubchem Assay
PRRID_0322	Low Molecular Weight Hyaluronic Acid (LMW-HA) Click for more detail	Host (Endogenous) (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Glycosaminoglycan	Natural	It leads to the production of antimicrobial peptide beta defensins 2.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Dorsal skin	NA	O00206.fasta	O00206	839	It leadsto the induction of an antibacterial response.	ELISA	18641349	2008	Pubchem Assay
PRRID_0323	Low Molecular Weight Hyaluronic Acid (LMW-HA) Click for more detail	Host (Endogenous) (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Glycosaminoglycan	Natural	It leads to the production of antimicrobial peptide beta defensins 2.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Dorsal skin	NA	Q9QUK6.fasta	Q9QUK6	835	It leadsto the induction of an antibacterial response.	ELISA	18641349	2008	Pubchem Assay
PRRID_0323	Low Molecular Weight Hyaluronic Acid (LMW-HA) Click for more detail	Host (Endogenous) (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Glycosaminoglycan	Natural	It leads to the production of antimicrobial peptide beta defensins 2.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Dorsal skin	NA	Q9QUK6.fasta	Q9QUK6	835	It leadsto the induction of an antibacterial response.	ELISA	18641349	2008	Pubchem Assay
PRRID_0324	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	NA	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58681.fasta	P58681	1050	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0324	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	NA	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58681.fasta	P58681	1050	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0327	MG149 Click for more detail	Mycoplasma genitalium (Bacteria)	CCCCCCCC1=CC=C(C=C1)CCC2=C(C(=CC=C2)O)C(=O)O	NA	Lipoprotein	Natural	On binding to the TLR2, it induces the activation of NF-	Toll-like receptor (TLR1 and Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Kidney cell line, 293T	LRR	NA	NA	NA	It has a immunostimulatory role	ELISA	18474641	2008	NA
PRRID_0327	MG149 Click for more detail	Mycoplasma genitalium (Bacteria)	CCCCCCCC1=CC=C(C=C1)CCC2=C(C(=CC=C2)O)C(=O)O	NA	Lipoprotein	Natural	On binding to the TLR2, it induces the activation of NF-	Toll-like receptor (TLR1 and Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Kidney cell line, 293T	LRR	NA	NA	NA	It has a immunostimulatory role	ELISA	18474641	2008	NA
PRRID_0328	P8 proteoglycolipid Click for more detail	Trypanosoma (Leishmania pifanoi)	NA	NA	Glycolipid	Natural	immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUK6.fasta	Q9QUK6	835	NA	Luciferase assay.	18299340	2008	Pubchem Assay
PRRID_0328	P8 proteoglycolipid Click for more detail	Trypanosoma (Leishmania pifanoi)	NA	NA	Glycolipid	Natural	immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUK6.fasta	Q9QUK6	835	NA	Luciferase assay.	18299340	2008	Pubchem Assay
PRRID_0331	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	It leads to the increased p38 MAPK activity and produce antimicrobial peptide Œ≤-defensin-2 (mBD-2).	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Pleural mesothelial cells	NA	Q9QUN7.fasta	Q9QUN7	784	PGN-activated PMC-derived mBD-2 significantly killed Staphylococcus aureus.	Antimicrobial assay	18621910	2008	Pubchem Assay
PRRID_0331	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	It leads to the increased p38 MAPK activity and produce antimicrobial peptide Œ≤-defensin-2 (mBD-2).	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Pleural mesothelial cells	NA	Q9QUN7.fasta	Q9QUN7	784	PGN-activated PMC-derived mBD-2 significantly killed Staphylococcus aureus.	Antimicrobial assay	18621910	2008	Pubchem Assay
PRRID_0332	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN stimulation leads to the activation of phospholipase C	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macrophages and Dendritic cells	NA	Q9QUN7.fasta	Q9QUN7	784	It has the role in immuno inflammation.	ELISA	18233961	2008	Pubchem Assay
PRRID_0332	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN stimulation leads to the activation of phospholipase C	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macrophages and Dendritic cells	NA	Q9QUN7.fasta	Q9QUN7	784	It has the role in immuno inflammation.	ELISA	18233961	2008	Pubchem Assay
PRRID_0333	Plant polysaccharide (EP) Click for more detail	Echinacea purpurea(plant)	NA	NA	Carbohydrate	Natural	It leads to the activation of NF-Œ∫B and stimulates the production of IL-6, TNF, IL-12 and NO.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Peritoneal macrophages	NA	Q9QUK6.fasta	Q9QUK6	835	Echinacea polysaccharides have immunomodulatory activity.	ELISA	18618312	2008	Pubchem Assay
PRRID_0333	Plant polysaccharide (EP) Click for more detail	Echinacea purpurea(plant)	NA	NA	Carbohydrate	Natural	It leads to the activation of NF-Œ∫B and stimulates the production of IL-6, TNF, IL-12 and NO.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Peritoneal macrophages	NA	Q9QUK6.fasta	Q9QUK6	835	Echinacea polysaccharides have immunomodulatory activity.	ELISA	18618312	2008	Pubchem Assay
PRRID_0334	poly(A:U) Click for more detail	synthetic oligonucleotide (others)	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	17981792	2008	NA
PRRID_0334	poly(A:U) Click for more detail	synthetic oligonucleotide (others)	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	17981792	2008	NA
PRRID_0335	poly(A:U) Click for more detail	synthetic oligonucleotide (others)	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	17981792	2008	NA
PRRID_0335	poly(A:U) Click for more detail	synthetic oligonucleotide (others)	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	17981792	2008	NA
PRRID_0336	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	They produce the proinflammatory molecule ICAM1 and secrete functionally active CCL2 chemokine.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Sertoli cells	LRR	Q99MB1.fasta	Q99MB1	905	Poly (I:C) elicits both inflammatory and antiviral responses in Sertoli cells.	ELISA	18596219	2008	Pubchem Assay
PRRID_0336	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	They produce the proinflammatory molecule ICAM1 and secrete functionally active CCL2 chemokine.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Sertoli cells	LRR	Q99MB1.fasta	Q99MB1	905	Poly (I:C) elicits both inflammatory and antiviral responses in Sertoli cells.	ELISA	18596219	2008	Pubchem Assay
PRRID_0337	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It leads to up-regulation of the genes interferon (IFN)-alpha1/alpha2, Mx, CXCL10, IL-1beta, IFN-gamma and CD83.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Salmo salar L.	Spleen and head kidney	NA	NA	NA	NA	It resulted into viral recognition, resulting in an enhanced innate immune response.	NA	18602433	2008	NA
PRRID_0337	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It leads to up-regulation of the genes interferon (IFN)-alpha1/alpha2, Mx, CXCL10, IL-1beta, IFN-gamma and CD83.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Salmo salar L.	Spleen and head kidney	NA	NA	NA	NA	It resulted into viral recognition, resulting in an enhanced innate immune response.	NA	18602433	2008	NA
PRRID_0338	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Stilmulation leads to the activation of the NF-KappaB.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Primary Human Keratinocytes	NA	O15455.fasta	O15455	904	It is responsible for the antiviral defense status.	ELISA	18684960	2008	Pubchem Assay
PRRID_0338	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Stilmulation leads to the activation of the NF-KappaB.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Primary Human Keratinocytes	NA	O15455.fasta	O15455	904	It is responsible for the antiviral defense status.	ELISA	18684960	2008	Pubchem Assay
PRRID_0342	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Poly(I:C) stimulate the secretion of cytokines and chemokines such as, IL-6, RANTES/CCL5 and MCP-1/CCL2.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Mesothelial cells	NA	O15455.fasta	O15455	904	It leads to the inflammation and infection of mesothelial cells.	ELISA	19005739	2008	Pubchem Assay
PRRID_0342	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Poly(I:C) stimulate the secretion of cytokines and chemokines such as, IL-6, RANTES/CCL5 and MCP-1/CCL2.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Mesothelial cells	NA	O15455.fasta	O15455	904	It leads to the inflammation and infection of mesothelial cells.	ELISA	19005739	2008	Pubchem Assay
PRRID_0345	SalP Click for more detail	Bacteria	NA	NA	Lipoprotein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	human corneal epithelial	NA	O60603.fasta	O60603	784	NA	Western Blot analysis	18191935	2008	Pubchem Assay
PRRID_0345	SalP Click for more detail	Bacteria	NA	NA	Lipoprotein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	human corneal epithelial	NA	O60603.fasta	O60603	784	NA	Western Blot analysis	18191935	2008	Pubchem Assay
PRRID_0346	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	initiate intracellular signaling cascades that may lead to host inflammation.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	epithelial cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	immunohistochemistry	18793367	2008	Pubchem Assay
PRRID_0346	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	initiate intracellular signaling cascades that may lead to host inflammation.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	epithelial cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	immunohistochemistry	18793367	2008	Pubchem Assay
PRRID_0347	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	initiate intracellular signaling cascades that may lead to host inflammation.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	epithelial cells	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	NA	immunohistochemistry	18793367	2008	Pubchem Assay
PRRID_0347	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	initiate intracellular signaling cascades that may lead to host inflammation.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	epithelial cells	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	NA	immunohistochemistry	18793367	2008	Pubchem Assay
PRRID_0349	Staphylococcus aureus Click for more detail	S. aureus (Bacteria)	NA	NA	Whole organism	Natural	S. aureus induces IL-8 and TNF-alpha release by CBMC.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Cord Blood-Derived Mast Cells (CBMC)	NA	O60603.fasta	O60603	784	S. aureus adheres to, invades, survives in, and stimulates human mast cells with the involvement of CD48 and TLR2.	ELISA	18644875	2008	Pubchem Assay
PRRID_0349	Staphylococcus aureus Click for more detail	S. aureus (Bacteria)	NA	NA	Whole organism	Natural	S. aureus induces IL-8 and TNF-alpha release by CBMC.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Cord Blood-Derived Mast Cells (CBMC)	NA	O60603.fasta	O60603	784	S. aureus adheres to, invades, survives in, and stimulates human mast cells with the involvement of CD48 and TLR2.	ELISA	18644875	2008	Pubchem Assay
PRRID_0350	T.g.HSP70 Click for more detail	T. gondii (others)	MGSSHHHHHHSSGLVPRGSHMLEMADSPAVGIDLGTTYSCVGVWKNDAVEIIANDQGNRTTPSYVAFTDTERLVGDAAKNQVARNPENTIFDAKRLIGRKFDDPSVQSDMKHWPFKVIAGPGDKPLIEVTYQGEKKTFHPEEVSAMVLGKMKEIAEAYLGKEVKEAVITVLAYFNDSQRQATKDAGTIAGLSVLRIINEPTAAAIAYGLDKKGCGEMNVLIFDMGGGTFDVSLLTIEDGIFEVKATAGDTHLGGEDFDNRLVDFCVQDFKRKNRGKDISTNSRALRRLRTQCERTKRTLSSSIQATIEIDSLFEGIDYSVSISRARFEELCMDYFRNSLLPVEKVLKDSGIDKRSVSEVVLVGGSTRIPKIQQLITDFFNGKEPCRSINPDEAVAYGAAVQAAILKGVTSSQVQDLLLLDVALLSLGLETAGGVMTKLIERNTTIPTKKSQTFTTYADNQPGVLIQVYEGERAMTKDNNLLGKFHLDGIPPAPRGVPQIEVTFDIDANGIMNVTAQDKSTGKSNQITITNDKGRLSASEIDRMVQEAEKYKAEDEQNKHRVEAKNGLENYCYHMRQTLDDEKLKDKISSEDRDTANKAIQEALDWLDKNQLAEKEEFEAKQKEVESVCTPIITKLYQAGAAAGGMPGGMGGMPGGMGGMPGGMGGMPGGMGSGC	674	Protein	Natural	It leads to the activation of cytosolic phospholipase A2 and platelet-activating factor and activated the PAF production.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Spleenocytes	NA	Q9QUK6.fasta	Q9QUK6	835	It induces the lethal anaphylactic reaction.	NA	18667035	2008	Pubchem Assay
PRRID_0350	T.g.HSP70 Click for more detail	T. gondii (others)	MGSSHHHHHHSSGLVPRGSHMLEMADSPAVGIDLGTTYSCVGVWKNDAVEIIANDQGNRTTPSYVAFTDTERLVGDAAKNQVARNPENTIFDAKRLIGRKFDDPSVQSDMKHWPFKVIAGPGDKPLIEVTYQGEKKTFHPEEVSAMVLGKMKEIAEAYLGKEVKEAVITVLAYFNDSQRQATKDAGTIAGLSVLRIINEPTAAAIAYGLDKKGCGEMNVLIFDMGGGTFDVSLLTIEDGIFEVKATAGDTHLGGEDFDNRLVDFCVQDFKRKNRGKDISTNSRALRRLRTQCERTKRTLSSSIQATIEIDSLFEGIDYSVSISRARFEELCMDYFRNSLLPVEKVLKDSGIDKRSVSEVVLVGGSTRIPKIQQLITDFFNGKEPCRSINPDEAVAYGAAVQAAILKGVTSSQVQDLLLLDVALLSLGLETAGGVMTKLIERNTTIPTKKSQTFTTYADNQPGVLIQVYEGERAMTKDNNLLGKFHLDGIPPAPRGVPQIEVTFDIDANGIMNVTAQDKSTGKSNQITITNDKGRLSASEIDRMVQEAEKYKAEDEQNKHRVEAKNGLENYCYHMRQTLDDEKLKDKISSEDRDTANKAIQEALDWLDKNQLAEKEEFEAKQKEVESVCTPIITKLYQAGAAAGGMPGGMGGMPGGMGGMPGGMGGMPGGMGSGC	674	Protein	Natural	It leads to the activation of cytosolic phospholipase A2 and platelet-activating factor and activated the PAF production.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Spleenocytes	NA	Q9QUK6.fasta	Q9QUK6	835	It induces the lethal anaphylactic reaction.	NA	18667035	2008	Pubchem Assay
PRRID_0351	TUL4 Click for more detail	Mycoplasma pneumoniae (Bacteria)	NA	NA	Lipoprotein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)/Toll-like receptor (TLR1	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	capable of stimulating a proinflammatory response and the cellular receptors they trigger	NA	18079113	2008	NA
PRRID_0351	TUL4 Click for more detail	Mycoplasma pneumoniae (Bacteria)	NA	NA	Lipoprotein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)/Toll-like receptor (TLR1	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	capable of stimulating a proinflammatory response and the cellular receptors they trigger	NA	18079113	2008	NA
PRRID_0353	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	NA	Natural	initiate intracellular signaling cascades that may lead to host inflammation.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	basal epithelial layer.	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	immunohistochemistry	18793367	2008	Pubchem Assay
PRRID_0353	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	NA	Natural	initiate intracellular signaling cascades that may lead to host inflammation.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	basal epithelial layer.	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	immunohistochemistry	18793367	2008	Pubchem Assay
PRRID_0357	Aeromonas hydrophila Click for more detail	A.hydrophilla(Bacteria)	NA	NA	Whole organism	Natural	Toll-like receptor 4 signaling pathway is trigger by Aeromonas hydrophila infection.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Gobiocypris rarus	Gill, Heart, Intestine, Kidney, Liver, Muscle and Spleen tissues	LRR	NA	NA	NA	This is responsible for the recognition of the bacteria and elicit the immune response against it.	NA	19264133	2009	NA
PRRID_0357	Aeromonas hydrophila Click for more detail	A.hydrophilla(Bacteria)	NA	NA	Whole organism	Natural	Toll-like receptor 4 signaling pathway is trigger by Aeromonas hydrophila infection.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Gobiocypris rarus	Gill, Heart, Intestine, Kidney, Liver, Muscle and Spleen tissues	LRR	NA	NA	NA	This is responsible for the recognition of the bacteria and elicit the immune response against it.	NA	19264133	2009	NA
PRRID_0362	Chromosomal DNA Click for more detail	S. gordonii (Bacteria)	NA	NA	Whole organism	Natural	Stimulation elicits the production of tumour necrosis factor (TNF), interleukin (IL)-6, IL-10 and IL-12p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0362	Chromosomal DNA Click for more detail	S. gordonii (Bacteria)	NA	NA	Whole organism	Natural	Stimulation elicits the production of tumour necrosis factor (TNF), interleukin (IL)-6, IL-10 and IL-12p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0367	Grass carp reovirus Click for more detail	Grass carp reovirus (virus)	NA	NA	Whole organism	Natural	Toll-like receptor 4 signaling pathway is trigger by grass carp reovirus.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Gobiocypris rarus	Gill, Heart, Intestine, Kidney, Liver, Muscle and Spleen tissues	LRR	NA	NA	NA	This is responsible for the recognition of the virus and elicit the immune response against it.	NA	19264133	2009	NA
PRRID_0367	Grass carp reovirus Click for more detail	Grass carp reovirus (virus)	NA	NA	Whole organism	Natural	Toll-like receptor 4 signaling pathway is trigger by grass carp reovirus.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Gobiocypris rarus	Gill, Heart, Intestine, Kidney, Liver, Muscle and Spleen tissues	LRR	NA	NA	NA	This is responsible for the recognition of the virus and elicit the immune response against it.	NA	19264133	2009	NA
PRRID_0370	Lipoprotein Click for more detail	S. gordonii (Bacteria)	NA	NA	Lipoprotein	Natural	Stimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0370	Lipoprotein Click for more detail	S. gordonii (Bacteria)	NA	NA	Lipoprotein	Natural	Stimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0371	Lipoteichoic Acid (LTA) Click for more detail	S. aureus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	It induces the production of the pro-inflammatory cytokines such as TNF-alpha and CXCL8.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Odontoblasts	LRR	O60603.fasta	O60603	784	It has inflammatory/immune response agianst gram-positive bacteria.	ELISA	19250704	2009	Pubchem Assay
PRRID_0371	Lipoteichoic Acid (LTA) Click for more detail	S. aureus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	It induces the production of the pro-inflammatory cytokines such as TNF-alpha and CXCL8.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Odontoblasts	LRR	O60603.fasta	O60603	784	It has inflammatory/immune response agianst gram-positive bacteria.	ELISA	19250704	2009	Pubchem Assay
PRRID_0372	Lipoteichoic Acid (LTA) Click for more detail	S. aureus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	It induces the production of the pro-inflammatory cytokines such as TNF-alpha and CXCL8.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Dental pulp fibroblasts	LRR	O60603.fasta	O60603	784	It has inflammatory/immune response agianst gram-positive bacteria.	ELISA	19250704	2009	Pubchem Assay
PRRID_0372	Lipoteichoic Acid (LTA) Click for more detail	S. aureus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	It induces the production of the pro-inflammatory cytokines such as TNF-alpha and CXCL8.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Dental pulp fibroblasts	LRR	O60603.fasta	O60603	784	It has inflammatory/immune response agianst gram-positive bacteria.	ELISA	19250704	2009	Pubchem Assay
PRRID_0373	Lipoteichoic Acid (LTA) Click for more detail	S. aureus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	It induces the production of the pro-inflammatory cytokines such as TNF-alpha, IL-1beta and CXCL8.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Immature dendritic cells	LRR	O60603.fasta	O60603	784	It has inflammatory/immune response agianst gram-positive bacteria.	ELISA	19250704	2009	Pubchem Assay
PRRID_0373	Lipoteichoic Acid (LTA) Click for more detail	S. aureus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	It induces the production of the pro-inflammatory cytokines such as TNF-alpha, IL-1beta and CXCL8.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Immature dendritic cells	LRR	O60603.fasta	O60603	784	It has inflammatory/immune response agianst gram-positive bacteria.	ELISA	19250704	2009	Pubchem Assay
PRRID_0374	Lipoteichoic Acid (LTA) Click for more detail	S. gordonii (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	Stimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0374	Lipoteichoic Acid (LTA) Click for more detail	S. gordonii (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	Stimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0375	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	NA	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	MALP-2-induced degradation of I	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	lung epithelial cells (small airway lung epithelial (SALE))	NA	O60603.fasta	O60603	784	This induces the inflammatory response.	NF-kappaB-luciferase reporter assays	19265130	2009	Pubchem Assay
PRRID_0375	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	NA	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	MALP-2-induced degradation of I	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	lung epithelial cells (small airway lung epithelial (SALE))	NA	O60603.fasta	O60603	784	This induces the inflammatory response.	NF-kappaB-luciferase reporter assays	19265130	2009	Pubchem Assay
PRRID_0376	Peptidoglycan (PGN) Click for more detail	S. gordonii (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Stimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0376	Peptidoglycan (PGN) Click for more detail	S. gordonii (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Stimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0377	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Poly (I:C) induces the generation of IRF3-dependent type I IFN and triggers the activation of the Rho GTPase RhoA, which leads to the activation of NF-kappaB.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	lung epithelial cells (small airway lung epithelial (SALE))	NA	O15455.fasta	O15455	904	This induces the inflammatory response.	NF-kappaB-luciferase reporter assays	19265130	2009	Pubchem Assay
PRRID_0377	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Poly (I:C) induces the generation of IRF3-dependent type I IFN and triggers the activation of the Rho GTPase RhoA, which leads to the activation of NF-kappaB.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	lung epithelial cells (small airway lung epithelial (SALE))	NA	O15455.fasta	O15455	904	This induces the inflammatory response.	NF-kappaB-luciferase reporter assays	19265130	2009	Pubchem Assay
PRRID_0379	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0379	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0380	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0380	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0381	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0381	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0382	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0382	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay

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