Detailed description page of PRRDB2.0

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PRRID_0324 details
Primary information
PRRIDPRRID_0324
Ligand NameLoxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)
SourceNA
Sequence of ligandC=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O
LengthNA
TypeNucleic Acid
OccurenceSynthetic
Role of LigandIt induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-
Name of receptorToll-like receptor 7 (TLR7)
Type of receptorToll-like receptor (TLR)
Source Newborn Mice
LocalizationAstrocytes and microglia
DomainLRR
Sequence of ReceptorP58681.fasta
Swiss prot IDP58681
Length Of Receptor1050
FunctionIt induces a neuroinflammatory response in CNS.
Assay usedCytokines assay
PMID18490763
Year of Publication2008
Pubchem assayPubchem Assay
Primary information
PRRIDPRRID_0324
Ligand NameLoxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)
SourceNA
Sequence of ligandC=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O
LengthNA
TypeNucleic Acid
OccurenceSynthetic
Role of LigandIt induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-
Name of receptorToll-like receptor 7 (TLR7)
Type of receptorToll-like receptor (TLR)
Source Newborn Mice
LocalizationAstrocytes and microglia
DomainLRR
Sequence of ReceptorP58681.fasta
Swiss prot IDP58681
Length Of Receptor1050
FunctionIt induces a neuroinflammatory response in CNS.
Assay usedCytokines assay
PMID18490763
Year of Publication2008
Pubchem assayPubchem Assay