Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0151	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0151	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0152	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0152	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0153	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0153	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0154	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0154	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0155	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0155	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0156	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0156	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0157	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0157	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0158	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0158	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0159	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0159	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0160	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0160	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0161	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0161	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0162	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0162	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0177	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	Loxoribine (7-allyl-7,8- dihydro-8-oxo-guanosine) activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	NA	P58681.fasta	P58681	1050	It leads to the endosomal maturation.	ELISA	14579267	2003	Pubchem Assay
PRRID_0177	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	Loxoribine (7-allyl-7,8- dihydro-8-oxo-guanosine) activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	NA	P58681.fasta	P58681	1050	It leads to the endosomal maturation.	ELISA	14579267	2003	Pubchem Assay
PRRID_0182	PIM2 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0182	PIM2 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0183	PIM2 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0183	PIM2 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0184	PIM6 Click for more detail	Mycobacterium bovis Bacillus Calmette Guerin (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0184	PIM6 Click for more detail	Mycobacterium bovis Bacillus Calmette Guerin (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0185	PIM6 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0185	PIM6 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0186	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Resisuimod activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	Spleenocytes	NA	P58682.fasta	P58682	1032	It leads to the endosomal maturation.	ELISA	14579267	2003	Pubchem Assay
PRRID_0186	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Resisuimod activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	Spleenocytes	NA	P58682.fasta	P58682	1032	It leads to the endosomal maturation.	ELISA	14579267	2003	Pubchem Assay
PRRID_0195	Double-stranded ribonucleic acid (dsRNA) Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	O15455.fasta	O15455	904	production of pro-inflammatory cytokines	ELISA	14976262	2004	Pubchem Assay
PRRID_0195	Double-stranded ribonucleic acid (dsRNA) Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	O15455.fasta	O15455	904	production of pro-inflammatory cytokines	ELISA	14976262	2004	Pubchem Assay
PRRID_0196	dsRNA Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Alveolar and bronchial epithelial cells	NA	O15455.fasta	O15455	904	It causes pulmonary inflammation.	ELISA	15579900	2004	Pubchem Assay
PRRID_0196	dsRNA Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Alveolar and bronchial epithelial cells	NA	O15455.fasta	O15455	904	It causes pulmonary inflammation.	ELISA	15579900	2004	Pubchem Assay
PRRID_0197	Envelope protein Click for more detail	virus (Mouse Mammary Tumor Virus)	NA	NA	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUK6.fasta	Q9QUK6	835	NA	NA	14694089	2004	Pubchem Assay
PRRID_0197	Envelope protein Click for more detail	virus (Mouse Mammary Tumor Virus)	NA	NA	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUK6.fasta	Q9QUK6	835	NA	NA	14694089	2004	Pubchem Assay
PRRID_0198	glucuronoxylomannan Click for more detail	Cryptococcus neoformans(fungi)	NA	NA	Carbohydrate	Natural	It leads to the induction of tumor necrosis factor alpha, interleukin-4, IL-10, IL-12p70 and gamma interferon.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Lung	NA	Q9QUK6.fasta	Q9QUK6	835	It leads to the inflammatory response against the fungi Cryptococcus neoformans.	ELISA	15322035	2004	Pubchem Assay
PRRID_0198	glucuronoxylomannan Click for more detail	Cryptococcus neoformans(fungi)	NA	NA	Carbohydrate	Natural	It leads to the induction of tumor necrosis factor alpha, interleukin-4, IL-10, IL-12p70 and gamma interferon.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Lung	NA	Q9QUK6.fasta	Q9QUK6	835	It leads to the inflammatory response against the fungi Cryptococcus neoformans.	ELISA	15322035	2004	Pubchem Assay
PRRID_0199	glucuronoxylomannan Click for more detail	Cryptococcus neoformans(fungi)	NA	NA	Carbohydrate	Natural	It leads to the induction of tumor necrosis factor alpha, interleukin-4, IL-10, IL-12p70 and gamma interferon.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Lung	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response against the fungi Cryptococcus neoformans.	ELISA	15322035	2004	Pubchem Assay
PRRID_0199	glucuronoxylomannan Click for more detail	Cryptococcus neoformans(fungi)	NA	NA	Carbohydrate	Natural	It leads to the induction of tumor necrosis factor alpha, interleukin-4, IL-10, IL-12p70 and gamma interferon.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Lung	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response against the fungi Cryptococcus neoformans.	ELISA	15322035	2004	Pubchem Assay
PRRID_0200	glycoinositolphospholipids Click for more detail	Trypanosoma (others)	NA	NA	Glycolipid	Natural	It induces the secretion of TNF-alpha and IL-12, which leads the production of cytokine IFN-gamma	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	It leads to the production of the IFN-gamma, which is a key cytokine in host resistance to infection with T. cruzi.	NA	15361229	2004	NA
PRRID_0200	glycoinositolphospholipids Click for more detail	Trypanosoma (others)	NA	NA	Glycolipid	Natural	It induces the secretion of TNF-alpha and IL-12, which leads the production of cytokine IFN-gamma	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	It leads to the production of the IFN-gamma, which is a key cytokine in host resistance to infection with T. cruzi.	NA	15361229	2004	NA
PRRID_0204	Heme Click for more detail	Endogenous (others)	CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C)CCC(=O)O)CCC(=O)O	NA	Others	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	17502383	2004	NA
PRRID_0204	Heme Click for more detail	Endogenous (others)	CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C)CCC(=O)O)CCC(=O)O	NA	Others	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	17502383	2004	NA
PRRID_0205	Influenza virus Click for more detail	Influenza A (virus)	NA	NA	Whole cell	Natural	It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Alveolar and bronchial epithelial cells	NA	O15455.fasta	O15455	904	It causes pulmonary inflammation.	ELISA	15579900	2004	Pubchem Assay
PRRID_0205	Influenza virus Click for more detail	Influenza A (virus)	NA	NA	Whole cell	Natural	It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Alveolar and bronchial epithelial cells	NA	O15455.fasta	O15455	904	It causes pulmonary inflammation.	ELISA	15579900	2004	Pubchem Assay
PRRID_0206	Not Determined Click for more detail	Uropathogenic E.coli (Bacteria)	NA	NA	Others	Natural	elicit innate immune response	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	macrophages and liver, kidney, and bladder epithelial cells	NA	NA	NA	NA	NA	NA	15001781	2004	NA
PRRID_0206	Not Determined Click for more detail	Uropathogenic E.coli (Bacteria)	NA	NA	Others	Natural	elicit innate immune response	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	macrophages and liver, kidney, and bladder epithelial cells	NA	NA	NA	NA	NA	NA	15001781	2004	NA
PRRID_0211	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	ELISA	14976262	2004	Pubchem Assay
PRRID_0211	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	ELISA	14976262	2004	Pubchem Assay
PRRID_0212	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	ELISA	14976262	2004	Pubchem Assay
PRRID_0212	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	ELISA	14976262	2004	Pubchem Assay
PRRID_0213	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	induce type I interferons (IFN) and other cytokines production.	NA	14976261	2004	NA
PRRID_0213	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	induce type I interferons (IFN) and other cytokines production.	NA	14976261	2004	NA
PRRID_0214	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	induce type I interferons (IFN) and other cytokines production.	NA	14976261	2004	NA
PRRID_0214	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	induce type I interferons (IFN) and other cytokines production.	NA	14976261	2004	NA
PRRID_0217	tGPI-mucin Click for more detail	Trypanosoma (others)	MKWSALNMNEGRGQLNCFCDGYWLHFPWTNNPRDVRGSSFFCYFAFVLLCALHLLLCVCVPSVRGADTTDRSRRMCMRWSLVCRSCLHLPLPSMCWCCGRAVCVCVCVCLLPWIGVCVVRGVRRTVHAWLLPSPHVVCPLCVCLPHLSSPLLLSISLTVQISSTPLNDHTMMTTCRLLCALLVLALCCCPFLCVTATGTAKELNKADASAPSPPSNPPATTTGESGLQDVVSAAEPQDVDGDVRGTSGSETQSDGAADKSQKHDNNDTTGSQGSTNRSADQTDQNGEDPAATTTTTTTAPVAPSTTTTTEAPTTTTTRAPSRLREIDGSLSSSAWVCAPLLLAASALAYTTVG	353	Glycoprotein	Natural	It induces the secretion of TNF-alpha and IL-12, which leads the production of cytokine IFN-gamma	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	It leads to the production of the IFN-gamma, which is a key cytokine in host resistance to infection with T. cruzi.	NA	15361229	2004	NA
PRRID_0217	tGPI-mucin Click for more detail	Trypanosoma (others)	MKWSALNMNEGRGQLNCFCDGYWLHFPWTNNPRDVRGSSFFCYFAFVLLCALHLLLCVCVPSVRGADTTDRSRRMCMRWSLVCRSCLHLPLPSMCWCCGRAVCVCVCVCLLPWIGVCVVRGVRRTVHAWLLPSPHVVCPLCVCLPHLSSPLLLSISLTVQISSTPLNDHTMMTTCRLLCALLVLALCCCPFLCVTATGTAKELNKADASAPSPPSNPPATTTGESGLQDVVSAAEPQDVDGDVRGTSGSETQSDGAADKSQKHDNNDTTGSQGSTNRSADQTDQNGEDPAATTTTTTTAPVAPSTTTTTEAPTTTTTRAPSRLREIDGSLSSSAWVCAPLLLAASALAYTTVG	353	Glycoprotein	Natural	It induces the secretion of TNF-alpha and IL-12, which leads the production of cytokine IFN-gamma	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	It leads to the production of the IFN-gamma, which is a key cytokine in host resistance to infection with T. cruzi.	NA	15361229	2004	NA
PRRID_0218	Biglycan Click for more detail	Endogenous (others)	MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT	238	Carbohydrate	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	NA	O00206.fasta	O00206	839	synthesis of TNF-alpha and MIP-2.	Western blotting and ELISA.	16025156	2005	Pubchem Assay
PRRID_0218	Biglycan Click for more detail	Endogenous (others)	MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT	238	Carbohydrate	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	NA	O00206.fasta	O00206	839	synthesis of TNF-alpha and MIP-2.	Western blotting and ELISA.	16025156	2005	Pubchem Assay
PRRID_0219	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocytic cell line	extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	15661917	2005	NA
PRRID_0219	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocytic cell line	extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	15661917	2005	NA
PRRID_0222	Hemozoin Click for more detail	protozoa (Plasmodium falciparum) (others)	CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5]	NA	Others	Natural	immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	Toll/interleukin 1 receptor domain	Q9NR96.fasta	Q9NR96	1032	abrogated HZ-induced cytokine production	NA	15630134	2005	Pubchem Assay
PRRID_0222	Hemozoin Click for more detail	protozoa (Plasmodium falciparum) (others)	CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5]	NA	Others	Natural	immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	Toll/interleukin 1 receptor domain	Q9NR96.fasta	Q9NR96	1032	abrogated HZ-induced cytokine production	NA	15630134	2005	Pubchem Assay
PRRID_0223	Microparticles containingOVAand poly-U Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	BMDCs	NA	P58681.fasta	P58681	1050	It stimulates proinflammatory and antiviral responses.	ELISA	16278038	2005	Pubchem Assay
PRRID_0223	Microparticles containingOVAand poly-U Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	BMDCs	NA	P58681.fasta	P58681	1050	It stimulates proinflammatory and antiviral responses.	ELISA	16278038	2005	Pubchem Assay
PRRID_0224	Microparticles containingOVAand poly-U Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	BMDCs	NA	P58682.fasta	P58682	1032	It stimulates proinflammatory and antiviral responses.	ELISA	16278038	2005	Pubchem Assay
PRRID_0224	Microparticles containingOVAand poly-U Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	BMDCs	NA	P58682.fasta	P58682	1032	It stimulates proinflammatory and antiviral responses.	ELISA	16278038	2005	Pubchem Assay
PRRID_0226	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocytic cell line	extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	15661917	2005	NA
PRRID_0226	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocytic cell line	extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	15661917	2005	NA
PRRID_0227	profilin-like protein Click for more detail	protozoa (Toxoplasma gondi) (others)	MSDWDPVVKEWLVDTGYCCAGGIANAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	163	Protein	Natural	Immunostimulant	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	15860593	2005	NA
PRRID_0227	profilin-like protein Click for more detail	protozoa (Toxoplasma gondi) (others)	MSDWDPVVKEWLVDTGYCCAGGIANAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	163	Protein	Natural	Immunostimulant	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	15860593	2005	NA
PRRID_0228	Seeligeriolysin O ((rLSO483) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay
PRRID_0228	Seeligeriolysin O ((rLSO483) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay
PRRID_0229	Seeligeriolysin O ((rLSO483) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUK6.fasta	Q9QUK6	835	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay
PRRID_0229	Seeligeriolysin O ((rLSO483) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUK6.fasta	Q9QUK6	835	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay
PRRID_0230	Seeligeriolysin O (rLSO530) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay
PRRID_0230	Seeligeriolysin O (rLSO530) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay
PRRID_0231	Seeligeriolysin O (rLSO530) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUK6.fasta	Q9QUK6	835	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay
PRRID_0231	Seeligeriolysin O (rLSO530) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUK6.fasta	Q9QUK6	835	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay
PRRID_0232	crystallin Click for more detail	Host (Endogenous) (others)	MDVTIQHPWFKRTLGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISEVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAIPVSREEKPTSAPSS	173	Protein	Natural	It leads to the increased production of the inflammatory mediators TNF-alpha, IL-6, IL-10, and IL-12p70.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Synovial tissue	NA	O00206.fasta	O00206	839	It leads to the activationa and maturation of the dendritic cells	Cyokine assay	16709864	2006	Pubchem Assay
PRRID_0232	crystallin Click for more detail	Host (Endogenous) (others)	MDVTIQHPWFKRTLGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISEVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAIPVSREEKPTSAPSS	173	Protein	Natural	It leads to the increased production of the inflammatory mediators TNF-alpha, IL-6, IL-10, and IL-12p70.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Synovial tissue	NA	O00206.fasta	O00206	839	It leads to the activationa and maturation of the dendritic cells	Cyokine assay	16709864	2006	Pubchem Assay
PRRID_0233	3M-001 Click for more detail	small chemical derivatives (others)	NA	NA	imidazoquinolines	Synthetic	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	dendritic cells	NA	Q9NYK1.fasta	Q9NYK1	1049	production of pro-inflammatory cytokines	NA	17114492	2006	Pubchem Assay
PRRID_0233	3M-001 Click for more detail	small chemical derivatives (others)	NA	NA	imidazoquinolines	Synthetic	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	dendritic cells	NA	Q9NYK1.fasta	Q9NYK1	1049	production of pro-inflammatory cytokines	NA	17114492	2006	Pubchem Assay
PRRID_0234	3M-001 Click for more detail	small chemical derivatives (others)	NA	NA	imidazoquinolines	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	production of pro-inflammatory cytokines	NA	17114492	2006	NA
PRRID_0234	3M-001 Click for more detail	small chemical derivatives (others)	NA	NA	imidazoquinolines	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	production of pro-inflammatory cytokines	NA	17114492	2006	NA
PRRID_0235	3M-002 Click for more detail	small chemical derivatives (others)	NA	NA	imidazoquinolines	Synthetic	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	dendritic cells	NA	Q9NR97.fasta	Q9NR97	1041	production of pro-inflammatory cytokines	NA	17114492	2006	Pubchem Assay
PRRID_0235	3M-002 Click for more detail	small chemical derivatives (others)	NA	NA	imidazoquinolines	Synthetic	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	dendritic cells	NA	Q9NR97.fasta	Q9NR97	1041	production of pro-inflammatory cytokines	NA	17114492	2006	Pubchem Assay
PRRID_0236	3M-002 Click for more detail	small chemical derivatives (others)	NA	NA	imidazoquinolines	Synthetic	Immunostimulant	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	production of pro-inflammatory cytokines	NA	17114492	2006	NA
PRRID_0236	3M-002 Click for more detail	small chemical derivatives (others)	NA	NA	imidazoquinolines	Synthetic	Immunostimulant	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	production of pro-inflammatory cytokines	NA	17114492	2006	NA
PRRID_0237	3M-003 Click for more detail	small chemical derivatives (others)	NA	NA	imidazoquinolines	Synthetic	elicit innate immune response	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	production of pro-inflammatory cytokines	NA	17114492	2006	NA
PRRID_0237	3M-003 Click for more detail	small chemical derivatives (others)	NA	NA	imidazoquinolines	Synthetic	elicit innate immune response	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	production of pro-inflammatory cytokines	NA	17114492	2006	NA
PRRID_0238	3M-003 Click for more detail	small chemical derivatives (others)	NA	NA	imidazoquinolines	Synthetic	Immunostimulant	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	production of pro-inflammatory cytokines	NA	17114492	2006	NA
PRRID_0238	3M-003 Click for more detail	small chemical derivatives (others)	NA	NA	imidazoquinolines	Synthetic	Immunostimulant	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	production of pro-inflammatory cytokines	NA	17114492	2006	NA

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