Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0651lipo-arabinomannan

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M. tuberculosis (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturallipoprotein and lipoarabinomannan are the poteny activators of the TLR2Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)DNA samples from peripheral blood of TB patientsNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Immunostimulation and inflammationNA207979052010Pubchem Assay
PRRID_0651lipo-arabinomannan

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M. tuberculosis (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturallipoprotein and lipoarabinomannan are the poteny activators of the TLR2Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)DNA samples from peripheral blood of TB patientsNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Immunostimulation and inflammationNA207979052010Pubchem Assay
PRRID_0652Lipoteichoic Acid (LTA)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAAmphiphileNaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimerToll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAIt coauses the inflammationNA207403412010NA
PRRID_0652Lipoteichoic Acid (LTA)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAAmphiphileNaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimerToll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAIt coauses the inflammationNA207403412010NA
PRRID_0653Lipoteichoic Acid (LTA)

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E. coli(Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalPeptidoglycan is the potent activator of the TLR2Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)C57BL/6 MiceNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784Contributes to inflammatory responses induced by orthopaedic wear particles in cell culture and murine models of aseptic loosening of orthopaedic implantsNA207292142010Pubchem Assay
PRRID_0653Lipoteichoic Acid (LTA)

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E. coli(Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalPeptidoglycan is the potent activator of the TLR2Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)C57BL/6 MiceNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784Contributes to inflammatory responses induced by orthopaedic wear particles in cell culture and murine models of aseptic loosening of orthopaedic implantsNA207292142010Pubchem Assay
PRRID_0654Lipoteichoic Acid (LTA)

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Lactobacillus acidophilus, Prevotella melaninogenica, P. bivia and Mycobacterium smegmatis (BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalEnhanced HIV-1 expression in macrophagesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leads to the clearance of the pathogen from the systemNA207199932010Pubchem Assay
PRRID_0654Lipoteichoic Acid (LTA)

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Lactobacillus acidophilus, Prevotella melaninogenica, P. bivia and Mycobacterium smegmatis (BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalEnhanced HIV-1 expression in macrophagesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leads to the clearance of the pathogen from the systemNA207199932010Pubchem Assay
PRRID_0655Lipoteichoic Acid (LTA)

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BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalNAToll-like receptor 2 Arg753Gln (TLR-2 Arg753Gln)Toll-like receptor (TLR)FMF patientsmonocytes and granulocytesLeucine-rich Repeat (LRR) DomainNANANAUpregulate inflammation in FMF patientsNA207147962010NA
PRRID_0655Lipoteichoic Acid (LTA)

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BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalNAToll-like receptor 2 Arg753Gln (TLR-2 Arg753Gln)Toll-like receptor (TLR)FMF patientsmonocytes and granulocytesLeucine-rich Repeat (LRR) DomainNANANAUpregulate inflammation in FMF patientsNA207147962010NA
PRRID_0656Lipoteichoic Acid (LTA)

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Gram-positive bacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0656Lipoteichoic Acid (LTA)

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Gram-positive bacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0657Lipoteichoic Acid (LTA)

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Streptococcus (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2/6 (TLR2/6)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainNANANAIt leadsto the secretion of the proinfalmmatory cytokinesNA206201292010NA
PRRID_0657Lipoteichoic Acid (LTA)

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Streptococcus (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2/6 (TLR2/6)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainNANANAIt leadsto the secretion of the proinfalmmatory cytokinesNA206201292010NA
PRRID_0660Low Molecular Weight Hyaluronic Acid (LMW-HA)

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human umbilical cord (others)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONAEndogenousSyntheticBinding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Miceembryonic mouse telencephalon and NPCLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784its activation inhibits NPC proliferation and decreases cell proliferation.NA204560212010Pubchem Assay
PRRID_0660Low Molecular Weight Hyaluronic Acid (LMW-HA)

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human umbilical cord (others)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONAEndogenousSyntheticBinding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Miceembryonic mouse telencephalon and NPCLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784its activation inhibits NPC proliferation and decreases cell proliferation.NA204560212010Pubchem Assay
PRRID_0661Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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Guanosine (others)C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049Itresults into the inflammatory responseNA207131002010Pubchem Assay
PRRID_0661Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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Guanosine (others)C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049Itresults into the inflammatory responseNA207131002010Pubchem Assay
PRRID_0662Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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Guanosine (others)C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cellsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041Itresults into the inflammatory responseNA207131002010Pubchem Assay
PRRID_0662Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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Guanosine (others)C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cellsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041Itresults into the inflammatory responseNA207131002010Pubchem Assay
PRRID_0663Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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NAC=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticIt led to the activation of NF-κB and upregulate the expression of the antiapoptotic protein Bcl-2.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanLung cancer cellsNAQ9NYK1.fastaQ9NYK11049This resulted into increased tumor cell survival and resistance to apoptosis induced by chemotherapy.ELISA202374132010Pubchem Assay
PRRID_0663Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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NAC=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticIt led to the activation of NF-κB and upregulate the expression of the antiapoptotic protein Bcl-2.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanLung cancer cellsNAQ9NYK1.fastaQ9NYK11049This resulted into increased tumor cell survival and resistance to apoptosis induced by chemotherapy.ELISA202374132010Pubchem Assay
PRRID_0664LpqH

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Mtb H37Ra (Bacteria)MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS159LipoproteinNaturalIt activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanPrimary MonocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leads to the clearance of the pathogen via autophagyNA205609772010Pubchem Assay
PRRID_0664LpqH

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Mtb H37Ra (Bacteria)MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS159LipoproteinNaturalIt activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanPrimary MonocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leads to the clearance of the pathogen via autophagyNA205609772010Pubchem Assay
PRRID_0665LpqH

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Mtb H37Ra (Bacteria)MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS159LipoproteinNaturalIt activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction.Toll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanPrimary MonocytesLeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786It leads to the clearance of the pathogen via autophagyNA205609772010Pubchem Assay
PRRID_0665LpqH

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Mtb H37Ra (Bacteria)MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS159LipoproteinNaturalIt activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction.Toll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanPrimary MonocytesLeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786It leads to the clearance of the pathogen via autophagyNA205609772010Pubchem Assay
PRRID_0667LprG (Rv1411c)

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Mtb H37Rv (Bacteria)MRTPRRHCRRIAVLAAVSIAATVVAGCSSGSKPSGGPLPDAKPLVEEATAQTKALKSAHMVLTVNGKIPGLSLKTLSGDLTTNPTAATGNVKLTLGGSDIDADFVVFDGILYATLTPNQWSDFGPAADIYDPAQVLNPDTGLANVLANFADAKAEGRDTINGQNTIRISGKVSAQAVNQIAPPFNATQPVPATVWIQETGDHQLAQAQLDRGSGNSVQMTLSKWGEKVQVTKPPVS236LipoproteinNaturalDelivery of glycolipds to TLR2Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)C57BL/6 Mouse pulmonary aerosol Infection modelsNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784Reduces virulence of MtbELISA206940062010Pubchem Assay
PRRID_0667LprG (Rv1411c)

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Mtb H37Rv (Bacteria)MRTPRRHCRRIAVLAAVSIAATVVAGCSSGSKPSGGPLPDAKPLVEEATAQTKALKSAHMVLTVNGKIPGLSLKTLSGDLTTNPTAATGNVKLTLGGSDIDADFVVFDGILYATLTPNQWSDFGPAADIYDPAQVLNPDTGLANVLANFADAKAEGRDTINGQNTIRISGKVSAQAVNQIAPPFNATQPVPATVWIQETGDHQLAQAQLDRGSGNSVQMTLSKWGEKVQVTKPPVS236LipoproteinNaturalDelivery of glycolipds to TLR2Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)C57BL/6 Mouse pulmonary aerosol Infection modelsNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784Reduces virulence of MtbELISA206940062010Pubchem Assay
PRRID_0670macrophage-activating lipopeptide

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Mycoplasma fermentans (Bacteria)C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)NNALipopeptidesNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0670macrophage-activating lipopeptide

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Mycoplasma fermentans (Bacteria)C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)NNALipopeptidesNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0671Mannan

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Candida albicans(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)dendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA207131002010Pubchem Assay
PRRID_0671Mannan

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Candida albicans(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)dendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA207131002010Pubchem Assay
PRRID_0672Mannan

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Candida albicans(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leadsto the secretion of the proinfalmmatory cytokines and IFN-βNA206201292010Pubchem Assay
PRRID_0672Mannan

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Candida albicans(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leadsto the secretion of the proinfalmmatory cytokines and IFN-βNA206201292010Pubchem Assay
PRRID_0680Mitochondrial DNA

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rhabdomyosarcoma cells (others)NANANucleic AcidNaturalIt activates the PMN in circukation and promote the Ca2+ flux and phosphorylation of MAP kinasesToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNeutrophilsNAQ9NR96.fastaQ9NR961032It incites non-specific organ attack and suppresses chemotactic responsess to infective stimuli.Chemotaxis assay202036102010Pubchem Assay
PRRID_0680Mitochondrial DNA

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rhabdomyosarcoma cells (others)NANANucleic AcidNaturalIt activates the PMN in circukation and promote the Ca2+ flux and phosphorylation of MAP kinasesToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNeutrophilsNAQ9NR96.fastaQ9NR961032It incites non-specific organ attack and suppresses chemotactic responsess to infective stimuli.Chemotaxis assay202036102010Pubchem Assay
PRRID_0682mmLDL

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Native Human LDL (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinSyntheticThe binding of mmLDL, induces the production of TNF-and increasing the expression of TLR2 and TLR5Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMonocytes and MacrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages.ELISA204720102010Pubchem Assay
PRRID_0682mmLDL

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Native Human LDL (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinSyntheticThe binding of mmLDL, induces the production of TNF-and increasing the expression of TLR2 and TLR5Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMonocytes and MacrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages.ELISA204720102010Pubchem Assay
PRRID_0683mmLDL

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Native Human LDL (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinSyntheticThe binding of mmLDL, induces the production of TNF- and increasing the expression of TLR2 and TLR6Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMonocytes and MacrophagesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages.ELISA204720102010Pubchem Assay
PRRID_0683mmLDL

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Native Human LDL (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinSyntheticThe binding of mmLDL, induces the production of TNF- and increasing the expression of TLR2 and TLR6Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMonocytes and MacrophagesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages.ELISA204720102010Pubchem Assay
PRRID_0684MOMP

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Shigella flexneri (Bacteria)NANAProteinNaturalIt stimulates macrophages, up regulates the surface expression of MHC-II and B7-1 and enhances the production of different cytokines (such as ILp70, TNF-⍺, Il-6) and chemokines (like MIP-1⍺, MIP-1β and RANTES)Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacropahesLRRQ9QUN7.fastaQ9QUN7784It initiates event in the antibacterial host response.ELISA203474872010Pubchem Assay
PRRID_0684MOMP

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Shigella flexneri (Bacteria)NANAProteinNaturalIt stimulates macrophages, up regulates the surface expression of MHC-II and B7-1 and enhances the production of different cytokines (such as ILp70, TNF-⍺, Il-6) and chemokines (like MIP-1⍺, MIP-1β and RANTES)Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacropahesLRRQ9QUN7.fastaQ9QUN7784It initiates event in the antibacterial host response.ELISA203474872010Pubchem Assay
PRRID_0685MPLA

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Salmonella minnesota R595 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONAPattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Rabbitdendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainG1SH24.fastaG1SH248391,000-fold less toxic than LPS and can be used as vaccinesNA207131002010Pubchem Assay
PRRID_0685MPLA

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Salmonella minnesota R595 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONAPattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Rabbitdendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainG1SH24.fastaG1SH248391,000-fold less toxic than LPS and can be used as vaccinesNA207131002010Pubchem Assay
PRRID_0686MPLA

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Salmonella minnesota R595 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONAPattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Guinea Pigdendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainH0VSQ0.fastaH0VSQ08371,000-fold less toxic than LPS and can be used as vaccinesNA207131002010Pubchem Assay
PRRID_0686MPLA

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Salmonella minnesota R595 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONAPattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Guinea Pigdendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainH0VSQ0.fastaH0VSQ08371,000-fold less toxic than LPS and can be used as vaccinesNA207131002010Pubchem Assay
PRRID_0687MPLA

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Salmonella minnesota R595 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONAPattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Dogsdendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainF1PDB9.fastaF1PDB98331,000-fold less toxic than LPS and can be used as vaccinesNA207131002010Pubchem Assay
PRRID_0687MPLA

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Salmonella minnesota R595 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONAPattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Dogsdendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainF1PDB9.fastaF1PDB98331,000-fold less toxic than LPS and can be used as vaccinesNA207131002010Pubchem Assay
PRRID_0688MPLA

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Salmonella minnesota R595 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONAPattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Horsedendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainF6RL35.fastaF6RL358431,000-fold less toxic than LPS and can be used as vaccinesNA207131002010Pubchem Assay
PRRID_0688MPLA

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Salmonella minnesota R595 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONAPattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Horsedendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainF6RL35.fastaF6RL358431,000-fold less toxic than LPS and can be used as vaccinesNA207131002010Pubchem Assay
PRRID_0689Mrp14

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Mice (others)MIENYWTSFCGNHHTSSNCTVRFLQICFGITLSFLTLCICLFHKEPPKRIHQFFCLRLVSALFNGIIGSLDLVLGIWVLRENHSKPLILWLVILIQGFTWLFINLIICVRGTRIRKSSLRLLSIFSFFYGLVSSCLSVNNAVFGDELAVRTILDVLLLPGSVLLLLSAYKGYRFDESGESSLYEPLNAGDSNGFSEKADFDNRVSQFAKAGLFSTLSFWWLNSLIKRGNVKDLEEDDIPELRKEERAETCYSLFEENLIEQKRRLGSSCQPSILKVTVLCVWRELLTSGFFAFMKIVAVSAGPLLLNAFILVAEGNASFRYEGLVLAVLLFFSKMIESLSQRQWYFRCRIVGLRVRSLLTAAINKKQLRLNNSSRLIHSGSEIMNYATVDAYRIGEFPYWFHQLWTTSFQLLIALGILFHSVGVATFSALAVIILTVLCNAPIAKLQNKFQSELMTSQDERLKACNESLVNMKVLKLYAWESHFKKVIEKLRNIELKSLKAVQMRKAYNAVLFWSSPVFVSAATFATCYFLDIPLRASNVFTFVATLRLVQDPVRMIPDVIGVTIQAKVAFSRIATFLEAPELQGGERRRKQRSEGNQNAIIIKSASFSWEEKGSTKPNLRNVRLEVKFGEKVAVCGEVGSGKSTLLAAILGETPCVSGTIDFYGTIAYVSQTAWIQTGTIRDNILFGGVMDEHRYRETIQKSSLDKDLELLPDGDQTEIGERGVNLSGGQKQRIQLARALYQDADIYLLDDPFSAVDAHTASSLFQEYVMDALAGKAVLLVTHQVDFLPAFDSVLLMSDGEITEADTYQELLARSRDFQDLVNAHRETAGSERVVAVENPTKPVKEINRVISSQSKVLKPSRLIKQEEREKGDTGLRPYIQYMNQNKGYIFFFIASLAQVTFAVGQILQNSWMAANVDNPQVSTLKLILVYLLIGLCSVLCLMVRSVCVVIMCMKSSASLFSQLLNSLFRAPMSFYDSTPLGRILSRVSSDLSIVDLDV1453Damage-associated molecular patterns (DAMPs)NaturalBinding leads to the secretion of the IL-18Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceLeukocytes and endothelial cellsLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It promotes the inflammation and might be involved in the progression of inflammation during CD40L-induced autoimmunity. It is also crucial for the devlopment of CD8+ T cellsELISA204733082010Pubchem Assay
PRRID_0689Mrp14

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Mice (others)MIENYWTSFCGNHHTSSNCTVRFLQICFGITLSFLTLCICLFHKEPPKRIHQFFCLRLVSALFNGIIGSLDLVLGIWVLRENHSKPLILWLVILIQGFTWLFINLIICVRGTRIRKSSLRLLSIFSFFYGLVSSCLSVNNAVFGDELAVRTILDVLLLPGSVLLLLSAYKGYRFDESGESSLYEPLNAGDSNGFSEKADFDNRVSQFAKAGLFSTLSFWWLNSLIKRGNVKDLEEDDIPELRKEERAETCYSLFEENLIEQKRRLGSSCQPSILKVTVLCVWRELLTSGFFAFMKIVAVSAGPLLLNAFILVAEGNASFRYEGLVLAVLLFFSKMIESLSQRQWYFRCRIVGLRVRSLLTAAINKKQLRLNNSSRLIHSGSEIMNYATVDAYRIGEFPYWFHQLWTTSFQLLIALGILFHSVGVATFSALAVIILTVLCNAPIAKLQNKFQSELMTSQDERLKACNESLVNMKVLKLYAWESHFKKVIEKLRNIELKSLKAVQMRKAYNAVLFWSSPVFVSAATFATCYFLDIPLRASNVFTFVATLRLVQDPVRMIPDVIGVTIQAKVAFSRIATFLEAPELQGGERRRKQRSEGNQNAIIIKSASFSWEEKGSTKPNLRNVRLEVKFGEKVAVCGEVGSGKSTLLAAILGETPCVSGTIDFYGTIAYVSQTAWIQTGTIRDNILFGGVMDEHRYRETIQKSSLDKDLELLPDGDQTEIGERGVNLSGGQKQRIQLARALYQDADIYLLDDPFSAVDAHTASSLFQEYVMDALAGKAVLLVTHQVDFLPAFDSVLLMSDGEITEADTYQELLARSRDFQDLVNAHRETAGSERVVAVENPTKPVKEINRVISSQSKVLKPSRLIKQEEREKGDTGLRPYIQYMNQNKGYIFFFIASLAQVTFAVGQILQNSWMAANVDNPQVSTLKLILVYLLIGLCSVLCLMVRSVCVVIMCMKSSASLFSQLLNSLFRAPMSFYDSTPLGRILSRVSSDLSIVDLDV1453Damage-associated molecular patterns (DAMPs)NaturalBinding leads to the secretion of the IL-18Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceLeukocytes and endothelial cellsLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It promotes the inflammation and might be involved in the progression of inflammation during CD40L-induced autoimmunity. It is also crucial for the devlopment of CD8+ T cellsELISA204733082010Pubchem Assay
PRRID_0690Mrp8

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Mice (others)MPSELEKALSNLIDVYHNYSNIQGNHHALYKNDFKKMVTTECPQFVQNINIENLFRELDINSDNAINFEEFLAMVIKVGVASHKDSHKE89Damage-associated molecular patterns (DAMPs)NaturalBinding leads to the secretion of the IL-17Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceLeukocytes and endothelial cellsLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It promotes the inflammation and might be involved in the progression of inflammation during CD40L-induced autoimmunity. It is also crucial for the devlopment of CD8+ T cellsELISA204733082010Pubchem Assay
PRRID_0690Mrp8

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Mice (others)MPSELEKALSNLIDVYHNYSNIQGNHHALYKNDFKKMVTTECPQFVQNINIENLFRELDINSDNAINFEEFLAMVIKVGVASHKDSHKE89Damage-associated molecular patterns (DAMPs)NaturalBinding leads to the secretion of the IL-17Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceLeukocytes and endothelial cellsLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It promotes the inflammation and might be involved in the progression of inflammation during CD40L-induced autoimmunity. It is also crucial for the devlopment of CD8+ T cellsELISA204733082010Pubchem Assay
PRRID_0691MsST

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Streptococcus thermophilus lacZ (Bacteria)MNMTEKIQTYLNDPKIVSVNTVDAHSDHKYFESLEEFSEGEMKLRQSLNGKWKIHYAQNTNQVLKDFYKTEFDETDLNFINVPGHLELQGFGSPQYVNTQYPWDGKEFLRPPQVPQESNAVASYVKHFTLNDALKDKKVFISFQGVATSIFVWVNGNFVGYSEDSFTPSEFEISDYLVEGDNKLAVAVYRYSTASWLEDQDFWRLYGIFRDVYLYAIPKVHVQDLFVKGDYDYQTKAGQLDIDLKTVGDYEDKKIKYVLSDYEGIVTEGDASVNGDGELSVSLENLKIKPWSAESPKLYDLILHVLDDDQVVEVVPVKVGFRRFEIKDKLMLLNGKRIVFKGVNRHEFNARTGRCITEEDMLWDIKVMKQHNINAVRTSHYPNQTRWYELCDEYGLYVIDEANLETHGTWQKLGLCEPSWNIPASEPEWLPACLDRANNMFQRDKNHASVIIWSCGNESYAGKDIADMADYFRSVDNTRPVHYEGVAWCREFDYITDIESRMYAKPADIEEYLTTGKLVDLSSVSDKHFASGNLTNKPQKPYISCEYMHTMGNSGGGLQLYTDLEKYPEYQGGFIWDFIDQAIYKTLPNGSEFLSYGGDWHDRPSDYEFCGNGIVFADRTLTPKLQTVKHLYSNIKIAVDEKSVTIKNDNLFEDLSAYTFLARVYEDGRKVSESEYHFDVKPGEEATFPVNFVVEASNSEQIYEVACVLREATEWAPKGHEIVRGQYVVEKISTETPVKAPLNVVEGDFNIGIQGQNFSILLSRAQNTLVSAKYNGVEFIEKGPKLSFTRAYTDNDRGAGYPFEMAGWKVAGNYSKVTDTQIQIEDDSVKVTYVHELPGLSDVEVKVTYQVDYKGRIFVTANYDGKAGLPNFPEFGLEFAIGSQFTNLSYYGYGAEESYRDKLPGAYLGRYETSVEKTFAPYLMPQESGNHYGTREFTVSDDNHNGLKFTALNKAFEFSALRNSTEQIENARHQYELQESDATWIKVLAAQMGVGGDDTW1026Nucleic AcidNaturalIt increases the number of CD80+CD11c+and CD86+CD11c+ dendritic cells and CD4+CD25+ regulatory T cells and also induces the production of IL-6.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceSpleenocytesLRRQ99MB1.fastaQ99MB1905It is a potent stimulators of innate immunity.ELISA201636262010Pubchem Assay
PRRID_0691MsST

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Streptococcus thermophilus lacZ (Bacteria)MNMTEKIQTYLNDPKIVSVNTVDAHSDHKYFESLEEFSEGEMKLRQSLNGKWKIHYAQNTNQVLKDFYKTEFDETDLNFINVPGHLELQGFGSPQYVNTQYPWDGKEFLRPPQVPQESNAVASYVKHFTLNDALKDKKVFISFQGVATSIFVWVNGNFVGYSEDSFTPSEFEISDYLVEGDNKLAVAVYRYSTASWLEDQDFWRLYGIFRDVYLYAIPKVHVQDLFVKGDYDYQTKAGQLDIDLKTVGDYEDKKIKYVLSDYEGIVTEGDASVNGDGELSVSLENLKIKPWSAESPKLYDLILHVLDDDQVVEVVPVKVGFRRFEIKDKLMLLNGKRIVFKGVNRHEFNARTGRCITEEDMLWDIKVMKQHNINAVRTSHYPNQTRWYELCDEYGLYVIDEANLETHGTWQKLGLCEPSWNIPASEPEWLPACLDRANNMFQRDKNHASVIIWSCGNESYAGKDIADMADYFRSVDNTRPVHYEGVAWCREFDYITDIESRMYAKPADIEEYLTTGKLVDLSSVSDKHFASGNLTNKPQKPYISCEYMHTMGNSGGGLQLYTDLEKYPEYQGGFIWDFIDQAIYKTLPNGSEFLSYGGDWHDRPSDYEFCGNGIVFADRTLTPKLQTVKHLYSNIKIAVDEKSVTIKNDNLFEDLSAYTFLARVYEDGRKVSESEYHFDVKPGEEATFPVNFVVEASNSEQIYEVACVLREATEWAPKGHEIVRGQYVVEKISTETPVKAPLNVVEGDFNIGIQGQNFSILLSRAQNTLVSAKYNGVEFIEKGPKLSFTRAYTDNDRGAGYPFEMAGWKVAGNYSKVTDTQIQIEDDSVKVTYVHELPGLSDVEVKVTYQVDYKGRIFVTANYDGKAGLPNFPEFGLEFAIGSQFTNLSYYGYGAEESYRDKLPGAYLGRYETSVEKTFAPYLMPQESGNHYGTREFTVSDDNHNGLKFTALNKAFEFSALRNSTEQIENARHQYELQESDATWIKVLAAQMGVGGDDTW1026Nucleic AcidNaturalIt increases the number of CD80+CD11c+and CD86+CD11c+ dendritic cells and CD4+CD25+ regulatory T cells and also induces the production of IL-6.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceSpleenocytesLRRQ99MB1.fastaQ99MB1905It is a potent stimulators of innate immunity.ELISA201636262010Pubchem Assay
PRRID_0695murine cytomegalovirus

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MCMV (virus)NANANucleic AcidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIFToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomesLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904it lead to the secretion of IFN-βNA206201292010Pubchem Assay
PRRID_0695murine cytomegalovirus

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MCMV (virus)NANANucleic AcidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIFToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomesLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904it lead to the secretion of IFN-βNA206201292010Pubchem Assay
PRRID_0696mutated SOD1

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exogenous (others)NANAProteinSyntheticNAToll-like receptor 14 (TLR14)Toll-like receptor (TLR)MicemicrogliaNAP10810.fastaP10810366activation and toxicity of microgliaNA207066422010Pubchem Assay
PRRID_0696mutated SOD1

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exogenous (others)NANAProteinSyntheticNAToll-like receptor 14 (TLR14)Toll-like receptor (TLR)MicemicrogliaNAP10810.fastaP10810366activation and toxicity of microgliaNA207066422010Pubchem Assay
PRRID_0698N1L

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Vaccinia(virus)MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK117ProteinNaturalSuppress NF-κB activation (Bind to IKKγ)Toll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANASuppress cytokine productionNA206720472010NA
PRRID_0698N1L

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Vaccinia(virus)MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK117ProteinNaturalSuppress NF-κB activation (Bind to IKKγ)Toll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANASuppress cytokine productionNA206720472010NA
PRRID_0700NA

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Edwardsiella tarda(Bacteria)NANANANaturalIt's binding leads to the release of the arra of cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Paralichthys olivaceusHead KidneyLeucine-rich Repeat (LRR) DomainE9RGG6.fastaE9RGG6868It provides immune response against the E.tardaNA207285382010Pubchem Assay
PRRID_0700NA

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Edwardsiella tarda(Bacteria)NANANANaturalIt's binding leads to the release of the arra of cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Paralichthys olivaceusHead KidneyLeucine-rich Repeat (LRR) DomainE9RGG6.fastaE9RGG6868It provides immune response against the E.tardaNA207285382010Pubchem Assay
PRRID_0706naked dsRNS (poly(I:C))

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BacteriaC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticinduced a reduction in maximal mitochondrial respirationToll-like receptor 3,7,9 (TLR3/7/9)Toll-like receptor (TLR)HumanHuman hepatocytes (HepG2 cells)Leucine-rich Repeat (LRR) DomainNANANAThis resultsinto mitochondrial dysfunction which is accompanied by caspase-8NA206912862010NA
PRRID_0706naked dsRNS (poly(I:C))

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BacteriaC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticinduced a reduction in maximal mitochondrial respirationToll-like receptor 3,7,9 (TLR3/7/9)Toll-like receptor (TLR)HumanHuman hepatocytes (HepG2 cells)Leucine-rich Repeat (LRR) DomainNANANAThis resultsinto mitochondrial dysfunction which is accompanied by caspase-8NA206912862010NA
PRRID_0707Nef

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HIV-1 (virus)MGGKWSKSSVIGWPTVRERMRRAEPAADRVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKIEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC206ProteinNaturalInhibit ERK activation (Dephosphorylation of ERK by induced MKP-1)Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress TNF-α productionNA206720472010Pubchem Assay
PRRID_0707Nef

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HIV-1 (virus)MGGKWSKSSVIGWPTVRERMRRAEPAADRVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKIEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC206ProteinNaturalInhibit ERK activation (Dephosphorylation of ERK by induced MKP-1)Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress TNF-α productionNA206720472010Pubchem Assay
PRRID_0710NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of IRF3/7 activationToll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAInhibit IFN production in pDCNA206720472010NA
PRRID_0710NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of IRF3/7 activationToll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAInhibit IFN production in pDCNA206720472010NA
PRRID_0711NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of NF-κB and AP-1 activationToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress DC and T cell activationNA206720472010Pubchem Assay
PRRID_0711NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of NF-κB and AP-1 activationToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress DC and T cell activationNA206720472010Pubchem Assay
PRRID_0713NS1, NS2

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Human respiratory syncytial virus (RSV)MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP139, 124ProteinNaturalSuppress IRF3 activationToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032Suppress IFN production in mDCNA206720472010Pubchem Assay
PRRID_0713NS1, NS2

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Human respiratory syncytial virus (RSV)MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP139, 124ProteinNaturalSuppress IRF3 activationToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032Suppress IFN production in mDCNA206720472010Pubchem Assay
PRRID_0715NS3/4A

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Hepatitis C Virus (virus)APITAYAQQTRGLLGTIVTGLTGRDKNVVTGEVQVLSTATQTFLGTTVGGVMWTVYHGAGSRTLAGAKHPALQMYTNVDQDLVGWPAPSGAKSLEPCACGSADLYLITRDADVIPARRRGDSTASLLSPRPLACLKGSSGGPVMCPSGHVAGIFRAAVCTRGVAKALQFIPVETLSTQARSPSFSDNSTPPAVPQSYQVGYLHAPTGSGKSTKVPAAYVAQGYNVLVLNPSVAATLGFGSFMSRAYGVDPNIRTGNRTVTTGAKLTYSTYGKFLADGGCSGGAYDVIICDECHAQDATSILGIGTVLDQAETAGVRLTVLATATPPGSITVPHSNIEEVALGSEGEIPFYGKAIPIALLKGGRHLIFCHSKKKCEEIASKLRGMGLNAVAYYRGLDVSVIPTTGDVVVCATDALMTGYTGDFDSVIDCNVAVEQYVDFSLDPTFSIETRTAPQDAVSRSQRRGRTGRGRLGTYRYVAPGERPSGMFDSVVLCECYDAGCSWYDLQPAETTVRLRAYLSTPGLPVCQDHLDFWESVFTGLTHIDAHFLSQTKQQGLNFSYLTAYQATVCARAQAPPPSWDETWKCLVRLKPTLHGPTPLLYRLGPIQNETCLTHPVTKYIMACMSADLEVTTSTWVLLGGVLAALAAYCLSVGSVVIVGHIELGGKPALVPDREVLYQQYDEMEEC685ProteinNaturalDegrade TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress IFN-α/β production and Suppress CD4+ T cell activation by dysfunction of mDCsNA206720472010Pubchem Assay
PRRID_0715NS3/4A

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Hepatitis C Virus (virus)APITAYAQQTRGLLGTIVTGLTGRDKNVVTGEVQVLSTATQTFLGTTVGGVMWTVYHGAGSRTLAGAKHPALQMYTNVDQDLVGWPAPSGAKSLEPCACGSADLYLITRDADVIPARRRGDSTASLLSPRPLACLKGSSGGPVMCPSGHVAGIFRAAVCTRGVAKALQFIPVETLSTQARSPSFSDNSTPPAVPQSYQVGYLHAPTGSGKSTKVPAAYVAQGYNVLVLNPSVAATLGFGSFMSRAYGVDPNIRTGNRTVTTGAKLTYSTYGKFLADGGCSGGAYDVIICDECHAQDATSILGIGTVLDQAETAGVRLTVLATATPPGSITVPHSNIEEVALGSEGEIPFYGKAIPIALLKGGRHLIFCHSKKKCEEIASKLRGMGLNAVAYYRGLDVSVIPTTGDVVVCATDALMTGYTGDFDSVIDCNVAVEQYVDFSLDPTFSIETRTAPQDAVSRSQRRGRTGRGRLGTYRYVAPGERPSGMFDSVVLCECYDAGCSWYDLQPAETTVRLRAYLSTPGLPVCQDHLDFWESVFTGLTHIDAHFLSQTKQQGLNFSYLTAYQATVCARAQAPPPSWDETWKCLVRLKPTLHGPTPLLYRLGPIQNETCLTHPVTKYIMACMSADLEVTTSTWVLLGGVLAALAAYCLSVGSVVIVGHIELGGKPALVPDREVLYQQYDEMEEC685ProteinNaturalDegrade TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress IFN-α/β production and Suppress CD4+ T cell activation by dysfunction of mDCsNA206720472010Pubchem Assay
PRRID_0716NS5A

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Hepatitis C Virus (virus)MAGSWLRDVWDWICTVLSDFKTWLQSKLLPRLPGVPFLSCQRGYRGVWRGDGIMHTTCPCGAEITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNIKCPCQVPAPEFFTELDGVRLHRYAPACKPLLRDEVTFLVGLHQYPVGSQLPCEPEPNVTVLTSMLTDPSHITAETAKRRLARGSPPSMASSSASQLSAPSLKATCTTHHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLRAEEDEREVSVPAEILRKSRKFPQAMPIWARPDYNPPLLESWKNPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLTESTVSSALAELATKTFGSSESSAVDSGTATAPPDQPSDDGGSGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCCSMSH452ProteinNaturalInhibit NF-κB activation (Bind to MyD88) and Inhibit JNK activation (Bind to TRAF2)Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress cytokine production and Suppress TNF pathway activationNA206720472010Pubchem Assay
PRRID_0716NS5A

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Hepatitis C Virus (virus)MAGSWLRDVWDWICTVLSDFKTWLQSKLLPRLPGVPFLSCQRGYRGVWRGDGIMHTTCPCGAEITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNIKCPCQVPAPEFFTELDGVRLHRYAPACKPLLRDEVTFLVGLHQYPVGSQLPCEPEPNVTVLTSMLTDPSHITAETAKRRLARGSPPSMASSSASQLSAPSLKATCTTHHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLRAEEDEREVSVPAEILRKSRKFPQAMPIWARPDYNPPLLESWKNPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLTESTVSSALAELATKTFGSSESSAVDSGTATAPPDQPSDDGGSGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCCSMSH452ProteinNaturalInhibit NF-κB activation (Bind to MyD88) and Inhibit JNK activation (Bind to TRAF2)Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress cytokine production and Suppress TNF pathway activationNA206720472010Pubchem Assay
PRRID_0717ODN with CpG motif

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BacteriaNANANucleic AcidSyntheticODN and CpG motifs activates the TLR9, which results in the activation of the downstream signalling cascade.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Raw 264.7 macrophage cell lineCells of the immune system and initially localized at ERLeucine-rich Repeat (LRR) DomainQ9EQU3.fastaQ9EQU31032Pleiotropic immune responses and regulates apoptosisNA207398332010Pubchem Assay
PRRID_0717ODN with CpG motif

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BacteriaNANANucleic AcidSyntheticODN and CpG motifs activates the TLR9, which results in the activation of the downstream signalling cascade.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Raw 264.7 macrophage cell lineCells of the immune system and initially localized at ERLeucine-rich Repeat (LRR) DomainQ9EQU3.fastaQ9EQU31032Pleiotropic immune responses and regulates apoptosisNA207398332010Pubchem Assay
PRRID_0718OM-174

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E. coli(Bacteria)CCCCCCCCCCC[C@@H](O)CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](O)[C@H]2NC(=O)C[C@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O[C@@H]1OP(O)(O)=ONALipidNaturalit induce the expression of iNOS, tumour suppressive proteins and cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)RatLiverLeucine-rich Repeat (LRR) DomainNANANAIt results into inhibition of invasion and metastasis of HCCNA206756992010NA
PRRID_0718OM-174

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E. coli(Bacteria)CCCCCCCCCCC[C@@H](O)CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](O)[C@H]2NC(=O)C[C@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O[C@@H]1OP(O)(O)=ONALipidNaturalit induce the expression of iNOS, tumour suppressive proteins and cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)RatLiverLeucine-rich Repeat (LRR) DomainNANANAIt results into inhibition of invasion and metastasis of HCCNA206756992010NA
PRRID_0719p30

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Human T-lymphotropic leukemia virus 1 (virus)MALCCFAFSAPCLHLRSRRSCSSCFLLATSAAFFSARLLRRAFSSSFLFKYSAICFSSSFSRSFFRFLFSSARRCRSRCVSPRGGAFSPGGPRRSRPRLSSSKDSKPSSTASSSSLSFNSSSKDNSPSTNSSTSRSSGHDTGKHRNSPADTKLTMLIISPLPRVWTESSFRIPSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTVPYPSTPLLPHPENL241ProteinNaturalSuppress TLR4 expression and Inhibit GSK3-βToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress cytokine production ad enhance IL-10 prductionNA206720472010Pubchem Assay
PRRID_0719p30

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Human T-lymphotropic leukemia virus 1 (virus)MALCCFAFSAPCLHLRSRRSCSSCFLLATSAAFFSARLLRRAFSSSFLFKYSAICFSSSFSRSFFRFLFSSARRCRSRCVSPRGGAFSPGGPRRSRPRLSSSKDSKPSSTASSSSLSFNSSSKDNSPSTNSSTSRSSGHDTGKHRNSPADTKLTMLIISPLPRVWTESSFRIPSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTVPYPSTPLLPHPENL241ProteinNaturalSuppress TLR4 expression and Inhibit GSK3-βToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress cytokine production ad enhance IL-10 prductionNA206720472010Pubchem Assay
PRRID_0720Paclitaxel

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NAC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)CNADrugSyntheticIt hasthe role in the activation of the adapter protein MyD88 was linked to reduction of apoptosis in cancer cells.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Human(Ovarian Cancer Patient)NALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA207283432010Pubchem Assay
PRRID_0720Paclitaxel

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NAC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)CNADrugSyntheticIt hasthe role in the activation of the adapter protein MyD88 was linked to reduction of apoptosis in cancer cells.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Human(Ovarian Cancer Patient)NALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA207283432010Pubchem Assay
PRRID_0721Diacylated Lipopeptide

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BacteriaNANALipopeptidesNaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0721Diacylated Lipopeptide

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BacteriaNANALipopeptidesNaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0722Pam2Cys

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B. burgdorferi(Bacteria)CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNAPeptidoglycanSyntheticInduction of protective immunity correlated with the development of Abs against an epitope on the C-terminus of OspAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0722Pam2Cys

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B. burgdorferi(Bacteria)CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNAPeptidoglycanSyntheticInduction of protective immunity correlated with the development of Abs against an epitope on the C-terminus of OspAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0723Pam3CSK4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONALipopeptidesSyntheticBinding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Miceembryonic mouse telencephalon and NPCLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784its activation inhibits NPC proliferation and decreases cell proliferation.NA204560212010Pubchem Assay
PRRID_0723Pam3CSK4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONALipopeptidesSyntheticBinding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Miceembryonic mouse telencephalon and NPCLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784its activation inhibits NPC proliferation and decreases cell proliferation.NA204560212010Pubchem Assay
PRRID_0724Pam3CSK4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONALipopeptidesSyntheticIt mediates the effect through a TLR2/PI3K/Aktdependent mechanism.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceHeartLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It induces induce cardioprotection against ischaemia/reperfusion injuryEMSA204213492010Pubchem Assay
PRRID_0724Pam3CSK4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONALipopeptidesSyntheticIt mediates the effect through a TLR2/PI3K/Aktdependent mechanism.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceHeartLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It induces induce cardioprotection against ischaemia/reperfusion injuryEMSA204213492010Pubchem Assay
PRRID_0725Pam3Cys

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Plasmodium falciparum circumsporozoite protein (others)CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONAPeptidoglycanSyntheticVaccine targeting malariaToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0725Pam3Cys

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Plasmodium falciparum circumsporozoite protein (others)CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONAPeptidoglycanSyntheticVaccine targeting malariaToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0726Pam3CysSK4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONAPeptidoglycanSyntheticNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)CNSNALeucine-rich Repeat (LRR) DomainNANANAIt causes neurodegenerationNA207066422010NA
PRRID_0726Pam3CysSK4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONAPeptidoglycanSyntheticNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)CNSNALeucine-rich Repeat (LRR) DomainNANANAIt causes neurodegenerationNA207066422010NA
PRRID_0727Pam3CysSK4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONAPeptidoglycanSyntheticNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)MacropahgesLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784Helps in IgM production and clear pathogen from bloodNA206968242010Pubchem Assay
PRRID_0727Pam3CysSK4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONAPeptidoglycanSyntheticNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)MacropahgesLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784Helps in IgM production and clear pathogen from bloodNA206968242010Pubchem Assay