Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0870	Atypic lipopolysaccharides Click for more detail	Leptospira interrogans (Bacteria)	NA	NA	Lipid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	21955443	2011	NA
PRRID_0870	Atypic lipopolysaccharides Click for more detail	Leptospira interrogans (Bacteria)	NA	NA	Lipid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	21955443	2011	NA
PRRID_0871	beta-defensin Click for more detail	Endogenous (others)	MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS	69	Peptide	Natural	Defensins are cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0871	beta-defensin Click for more detail	Endogenous (others)	MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS	69	Peptide	Natural	Defensins are cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0872	Bropirimine Click for more detail	NA	C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	experimental drug with¬†anti-cancer¬†and¬†antiviral¬†properties	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	B cells, dendritic cells, microglia, astrocytes	NA	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	21982558	2011	Pubchem Assay
PRRID_0872	Bropirimine Click for more detail	NA	C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	experimental drug with¬†anti-cancer¬†and¬†antiviral¬†properties	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	B cells, dendritic cells, microglia, astrocytes	NA	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	21982558	2011	Pubchem Assay
PRRID_0873	Bropirimine Click for more detail	NA	C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	experimental drug with¬†anti-cancer¬†and¬†antiviral¬†properties	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-13	NA	21955443	2011	NA
PRRID_0873	Bropirimine Click for more detail	NA	C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	experimental drug with¬†anti-cancer¬†and¬†antiviral¬†properties	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-13	NA	21955443	2011	NA
PRRID_0874	Chromatin-IgG complexes Click for more detail	Endogenous (others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Epithelial and B cells, dendritic cells, microglia, astrocyte, neuron	NA	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	21982558	2011	Pubchem Assay
PRRID_0874	Chromatin-IgG complexes Click for more detail	Endogenous (others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Epithelial and B cells, dendritic cells, microglia, astrocyte, neuron	NA	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	21982558	2011	Pubchem Assay
PRRID_0876	Diacylated Lipopeptide Click for more detail	Mycoplasma, Gram-positive bacteria	NA	NA	Lipid	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Myeloid cells, dendritic cells, microglia, astrocytes	NA	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0876	Diacylated Lipopeptide Click for more detail	Mycoplasma, Gram-positive bacteria	NA	NA	Lipid	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Myeloid cells, dendritic cells, microglia, astrocytes	NA	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0877	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipid	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	21955443	2011	NA
PRRID_0877	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipid	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	21955443	2011	NA
PRRID_0878	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Epithelial cells, dendritic cells, microglia, astrocytes,oligodendrocytes, neurons	NA	O15455.fasta	O15455	904	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21982558	2011	Pubchem Assay
PRRID_0878	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Epithelial cells, dendritic cells, microglia, astrocytes,oligodendrocytes, neurons	NA	O15455.fasta	O15455	904	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21982558	2011	Pubchem Assay
PRRID_0879	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	NA	intracellular TIR domains	Q99MB1.fasta	Q99MB1	905	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21959264	2011	Pubchem Assay
PRRID_0879	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	NA	intracellular TIR domains	Q99MB1.fasta	Q99MB1	905	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21959264	2011	Pubchem Assay
PRRID_0880	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21955443	2011	NA
PRRID_0880	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21955443	2011	NA
PRRID_0881	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21949866	2011	NA
PRRID_0881	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21949866	2011	NA
PRRID_0882	Envelope protein Click for more detail	Mouse mammary tumour virus	PTSACVTYPYAILLGLPQLIDIEKRGSTFHISCSSCRLTNCLDSSAYDYAAIIVKRPPYVLLPVDIGDEPWFDDSAIQTFRYATDLIRAKRFVAAIILGISALIAIITSFAVATTALVKEMQTATFVNNLHRNVTLALSEQRIIDLKLEARLNALEEVVLELGQDVANLKTRMSTRCHANYDFICVTPLPYNASESWERTKAHLLGIWNDNEISYNIQELTNLISDMSKQHIDTVDLSGLAQSFANGVKALNPLDWTQYFIFIGVGALLLVIVLMIFPIVFQCLAKSLDQVQSDLNVLLLKKKKGGNAAPAAGTGQVRKATEEAGL	326	Protein	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21955443	2011	NA
PRRID_0882	Envelope protein Click for more detail	Mouse mammary tumour virus	PTSACVTYPYAILLGLPQLIDIEKRGSTFHISCSSCRLTNCLDSSAYDYAAIIVKRPPYVLLPVDIGDEPWFDDSAIQTFRYATDLIRAKRFVAAIILGISALIAIITSFAVATTALVKEMQTATFVNNLHRNVTLALSEQRIIDLKLEARLNALEEVVLELGQDVANLKTRMSTRCHANYDFICVTPLPYNASESWERTKAHLLGIWNDNEISYNIQELTNLISDMSKQHIDTVDLSGLAQSFANGVKALNPLDWTQYFIFIGVGALLLVIVLMIFPIVFQCLAKSLDQVQSDLNVLLLKKKKGGNAAPAAGTGQVRKATEEAGL	326	Protein	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21955443	2011	NA
PRRID_0883	Fibrinogen Click for more detail	Endogenous (others)	MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG	211	Damage-associated molecular patterns (DAMPs)	Natural	initiates an inflammatory response by activating innate immune cells	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0883	Fibrinogen Click for more detail	Endogenous (others)	MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG	211	Damage-associated molecular patterns (DAMPs)	Natural	initiates an inflammatory response by activating innate immune cells	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0884	Fibrinogen Click for more detail	Host (Endogenous) (others)	MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG	211	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21955443	2011	NA
PRRID_0884	Fibrinogen Click for more detail	Host (Endogenous) (others)	MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG	211	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21955443	2011	NA
PRRID_0885	Fibronectin Click for more detail	NA	MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP	2386	Glycoprotein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21955443	2011	NA
PRRID_0885	Fibronectin Click for more detail	NA	MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP	2386	Glycoprotein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21955443	2011	NA
PRRID_0886	Fimbriae H protein (FimH) Click for more detail	Uropathogenic E.coli (Bacteria)	MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ	300	Protein	Natural	stimulate the innate immune system and elicits protective responses against bacterial and viral infections	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	C57BL/6 mice	NA	NA	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21945041	2011	Pubchem Assay
PRRID_0886	Fimbriae H protein (FimH) Click for more detail	Uropathogenic E.coli (Bacteria)	MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ	300	Protein	Natural	stimulate the innate immune system and elicits protective responses against bacterial and viral infections	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	C57BL/6 mice	NA	NA	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21945041	2011	Pubchem Assay
PRRID_0887	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Myeloid cells, epithelial cells, microglia, astrocytes	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	21982558	2011	Pubchem Assay
PRRID_0887	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Myeloid cells, epithelial cells, microglia, astrocytes	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	21982558	2011	Pubchem Assay
PRRID_0888	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	21955443	2011	NA
PRRID_0888	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	21955443	2011	NA
PRRID_0889	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	21949866	2011	NA
PRRID_0889	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	21949866	2011	NA
PRRID_0890	Flagellin Click for more detail	S. typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	elicits innate responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Human colon adenocarcinoma intestinal epithelial cells	amino (N) and carboxyl (C) domains (D) of the flagellin protein (ND1/2ECHCD2/1)	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	21949773	2011	Pubchem Assay
PRRID_0890	Flagellin Click for more detail	S. typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	elicits innate responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Human colon adenocarcinoma intestinal epithelial cells	amino (N) and carboxyl (C) domains (D) of the flagellin protein (ND1/2ECHCD2/1)	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	21949773	2011	Pubchem Assay
PRRID_0891	Fusion protein Click for more detail	Respiratory syncytial virus (virus)	MELLIHRLSAIFLTLAINALYLTSSQNITEEFYQSTCSAVSRGYFSALRTGWYTSVITIELSNIKETKCNGTDTKVKLIKQELDKYKNAVTELQLLMQNTPAANNRARREAPQYMNYTINTTKNLNVSISKKRKRRFLGFLLGVGSAIASGIAVSKVLHLEGEVNKIKNALLSTNKAVVSLSNGVSVLTSKVLDLKNYINNQLLPIVNQQSCRISNIETVIEFQQKNSRLLEINREFSVNAGVTTPLSTYMLTNSELLSLINDMPITNDQKKLMSSNVQIVRQQSYSIMSIIKEEVLAYVVQLPIYGVIDTPCWKLHTSPLCTTNIKEGSNICLTRTDRGWYCDNAGSVSFFPQADTCKVQSNRVFCDTMNSLTLPSEVSLCNTDIFNSKYDCKIMTSKTDISSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKLEGKNLYVKGEPIINYYDPLVFPSDEFDASISQVNEKINQSLAFIRRSDELLHNVNTGKSTTNIMITTIIIVIIVVLLSLIAIGLLLYCKAKNTPVTLSKDQLSGINNIAFSK	574	Protein	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21955443	2011	NA
PRRID_0891	Fusion protein Click for more detail	Respiratory syncytial virus (virus)	MELLIHRLSAIFLTLAINALYLTSSQNITEEFYQSTCSAVSRGYFSALRTGWYTSVITIELSNIKETKCNGTDTKVKLIKQELDKYKNAVTELQLLMQNTPAANNRARREAPQYMNYTINTTKNLNVSISKKRKRRFLGFLLGVGSAIASGIAVSKVLHLEGEVNKIKNALLSTNKAVVSLSNGVSVLTSKVLDLKNYINNQLLPIVNQQSCRISNIETVIEFQQKNSRLLEINREFSVNAGVTTPLSTYMLTNSELLSLINDMPITNDQKKLMSSNVQIVRQQSYSIMSIIKEEVLAYVVQLPIYGVIDTPCWKLHTSPLCTTNIKEGSNICLTRTDRGWYCDNAGSVSFFPQADTCKVQSNRVFCDTMNSLTLPSEVSLCNTDIFNSKYDCKIMTSKTDISSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKLEGKNLYVKGEPIINYYDPLVFPSDEFDASISQVNEKINQSLAFIRRSDELLHNVNTGKSTTNIMITTIIIVIIVVLLSLIAIGLLLYCKAKNTPVTLSKDQLSGINNIAFSK	574	Protein	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21955443	2011	NA
PRRID_0892	Glycoinositol phospholipids Click for more detail	eukaryotic cell membranes (others)	C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O	NA	Lipid	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0892	Glycoinositol phospholipids Click for more detail	eukaryotic cell membranes (others)	C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O	NA	Lipid	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0893	Glycoinositol phospholipids Click for more detail	Trypanosoma Cruzi (others)	C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O	NA	Lipid	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	21955443	2011	NA
PRRID_0893	Glycoinositol phospholipids Click for more detail	Trypanosoma Cruzi (others)	C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O	NA	Lipid	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	21955443	2011	NA
PRRID_0894	Glycolipids Click for more detail	eukaryotic cell membranes (others)	NA	NA	Lipid	Natural	Their role is to maintain the stability of the cell membrane and to facilitate cellular recognition, which is crucial to the immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0894	Glycolipids Click for more detail	eukaryotic cell membranes (others)	NA	NA	Lipid	Natural	Their role is to maintain the stability of the cell membrane and to facilitate cellular recognition, which is crucial to the immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0895	Glycolipids Click for more detail	Treponema maltophilum (others)	NA	NA	Lipid	Natural	Their role is to maintain the stability of the cell membrane and to facilitate cellular recognition, which is crucial to the immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21955443	2011	NA
PRRID_0895	Glycolipids Click for more detail	Treponema maltophilum (others)	NA	NA	Lipid	Natural	Their role is to maintain the stability of the cell membrane and to facilitate cellular recognition, which is crucial to the immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21955443	2011	NA
PRRID_0896	Gp96 (HSP90B1) Click for more detail	Endogenous (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Damage-associated molecular patterns (DAMPs)	Natural	It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0896	Gp96 (HSP90B1) Click for more detail	Endogenous (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Damage-associated molecular patterns (DAMPs)	Natural	It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0897	Gp96 (HSP90B1) Click for more detail	Endogenous (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Damage-associated molecular patterns (DAMPs)	Natural	It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0897	Gp96 (HSP90B1) Click for more detail	Endogenous (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Damage-associated molecular patterns (DAMPs)	Natural	It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0898	Heat-shock protein 70 Click for more detail	Endogenous (others)	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0898	Heat-shock protein 70 Click for more detail	Endogenous (others)	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0899	Heat-shock protein 70 Click for more detail	Endogenous (others)	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0899	Heat-shock protein 70 Click for more detail	Endogenous (others)	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0900	Heat-shock protein 70 Click for more detail	NA	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	21955443	2011	NA
PRRID_0900	Heat-shock protein 70 Click for more detail	NA	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	21955443	2011	NA
PRRID_0901	Heat-shock protein 70 Click for more detail	NA	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21955443	2011	NA
PRRID_0901	Heat-shock protein 70 Click for more detail	NA	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21955443	2011	NA
PRRID_0902	Heat-shock proteins 60 Click for more detail	Endogenous (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0902	Heat-shock proteins 60 Click for more detail	Endogenous (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0903	Heat-shock proteins 60 Click for more detail	Endogenous (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0903	Heat-shock proteins 60 Click for more detail	Endogenous (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0904	Heat-shock proteins 60 Click for more detail	NA	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21955443	2011	NA
PRRID_0904	Heat-shock proteins 60 Click for more detail	NA	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21955443	2011	NA
PRRID_0905	Heparan sulfate Click for more detail	Endogenous (others)	COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	released in responses to local stresses (hypoxia or inflammation)	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0905	Heparan sulfate Click for more detail	Endogenous (others)	COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	released in responses to local stresses (hypoxia or inflammation)	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0906	Heparan sulfate Click for more detail	NA	COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	induce the maturation of DCs	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21955443	2011	NA
PRRID_0906	Heparan sulfate Click for more detail	NA	COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	induce the maturation of DCs	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21955443	2011	NA
PRRID_0907	Heparan sulfate Click for more detail	NA	COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	induce the maturation of DCs	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	neutrophils, macrophages, and dendritic cells	TIR domain- containing adaptor protein-inducing IFN-	Q9QUK6.fasta	Q9QUK6	835	triggers the innate immune response and leads to the induction of adaptive immunity	NA	21949773	2011	Pubchem Assay
PRRID_0907	Heparan sulfate Click for more detail	NA	COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	induce the maturation of DCs	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	neutrophils, macrophages, and dendritic cells	TIR domain- containing adaptor protein-inducing IFN-	Q9QUK6.fasta	Q9QUK6	835	triggers the innate immune response and leads to the induction of adaptive immunity	NA	21949773	2011	Pubchem Assay
PRRID_0908	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE	215	Protein	Natural	HMGB1 plays a pivotal role in ischemic brain injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0908	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE	215	Protein	Natural	HMGB1 plays a pivotal role in ischemic brain injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0909	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	HMGB1 plays a pivotal role in ischemic brain injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	neutrophils, macrophages, and dendritic cells	TIR domain- containing adaptor protein-inducing IFN-	Q9QUK6.fasta	Q9QUK6	835	triggers the innate immune response and leads to the induction of adaptive immunity	NA	21949773	2011	Pubchem Assay
PRRID_0909	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	HMGB1 plays a pivotal role in ischemic brain injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	neutrophils, macrophages, and dendritic cells	TIR domain- containing adaptor protein-inducing IFN-	Q9QUK6.fasta	Q9QUK6	835	triggers the innate immune response and leads to the induction of adaptive immunity	NA	21949773	2011	Pubchem Assay
PRRID_0910	Hyaluronic acid Click for more detail	NA	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21955443	2011	NA
PRRID_0910	Hyaluronic acid Click for more detail	NA	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21955443	2011	NA
PRRID_0912	Imidazoquinoline Click for more detail	A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring	CC1=C(NC(=C(C1=C2C=CC(=C(C2=O)OC)OC)N)C3=NC4=C(C=C3)C(=O)C(=C5C4=NC(N5)(C)C)OC)C(=O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	Imidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergic	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	B cells, dendritic cells, microglia, astrocytes	NA	Q9NYK1.fasta	Q9NYK1	1049	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-12	NA	21982558	2011	Pubchem Assay
PRRID_0912	Imidazoquinoline Click for more detail	A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring	CC1=C(NC(=C(C1=C2C=CC(=C(C2=O)OC)OC)N)C3=NC4=C(C=C3)C(=O)C(=C5C4=NC(N5)(C)C)OC)C(=O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	Imidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergic	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	B cells, dendritic cells, microglia, astrocytes	NA	Q9NYK1.fasta	Q9NYK1	1049	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-12	NA	21982558	2011	Pubchem Assay
PRRID_0913	Imidazoquinoline Click for more detail	A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring	CC1=C(NC(=C(C1=C2C=CC(=C(C2=O)OC)OC)N)C3=NC4=C(C=C3)C(=O)C(=C5C4=NC(N5)(C)C)OC)C(=O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	Imidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergic	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-13	NA	21955443	2011	NA
PRRID_0913	Imidazoquinoline Click for more detail	A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring	CC1=C(NC(=C(C1=C2C=CC(=C(C2=O)OC)OC)N)C3=NC4=C(C=C3)C(=O)C(=C5C4=NC(N5)(C)C)OC)C(=O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	Imidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergic	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-13	NA	21955443	2011	NA
PRRID_0914	Imidazoquinoline Click for more detail	A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring	CC1=C(NC(=C(C1=C2C=CC(=C(C2=O)OC)OC)N)C3=NC4=C(C=C3)C(=O)C(=C5C4=NC(N5)(C)C)OC)C(=O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	Imidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergic	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	important role in the immune response to viral infection	NA	21955443	2011	NA
PRRID_0914	Imidazoquinoline Click for more detail	A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring	CC1=C(NC(=C(C1=C2C=CC(=C(C2=O)OC)OC)N)C3=NC4=C(C=C3)C(=O)C(=C5C4=NC(N5)(C)C)OC)C(=O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	Imidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergic	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	important role in the immune response to viral infection	NA	21955443	2011	NA
PRRID_0915	Imiquimod (R837) Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Amine analog to guanosine, is an immune response modifier with potent indirect antiviral activity.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	important role in the immune response to viral infection	NA	21949866	2011	NA
PRRID_0915	Imiquimod (R837) Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Amine analog to guanosine, is an immune response modifier with potent indirect antiviral activity.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	important role in the immune response to viral infection	NA	21949866	2011	NA
PRRID_0916	lipo-arabinomannan Click for more detail	Mycobacteria (Bacteria)	CCC(CO)NCCNC(CC)CO	NA	Glycolipid	Natural	serve as a modulin with immunoregulatory and anti-inflammatory effects.¬†	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0916	lipo-arabinomannan Click for more detail	Mycobacteria (Bacteria)	CCC(CO)NCCNC(CC)CO	NA	Glycolipid	Natural	serve as a modulin with immunoregulatory and anti-inflammatory effects.¬†	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0917	lipo-arabinomannan Click for more detail	Mycobacteria (Bacteria)	CCC(CO)NCCNC(CC)CO	NA	Glycolipid	Natural	serve as a modulin with immunoregulatory and anti-inflammatory effects.¬†	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	21955443	2011	NA
PRRID_0917	lipo-arabinomannan Click for more detail	Mycobacteria (Bacteria)	CCC(CO)NCCNC(CC)CO	NA	Glycolipid	Natural	serve as a modulin with immunoregulatory and anti-inflammatory effects.¬†	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	21955443	2011	NA
PRRID_0918	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS was also shown to play a role in alloimmune lung injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0918	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS was also shown to play a role in alloimmune lung injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0919	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	Intracellular TIR domains	O15455.fasta	O15455	904	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21959264	2011	Pubchem Assay
PRRID_0919	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	Intracellular TIR domains	O15455.fasta	O15455	904	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21959264	2011	Pubchem Assay
PRRID_0920	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Drosophila melanogaster	NA	Intracellular TIR domains	NA	NA	NA	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21959264	2011	NA
PRRID_0920	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Drosophila melanogaster	NA	Intracellular TIR domains	NA	NA	NA	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21959264	2011	NA
PRRID_0921	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS was also shown to play a role in alloimmune lung injury	Toll-like receptor 4/MD-2 (TLR4/MD-2)	Toll-like receptor (TLR)	Mice	NA	intracellular TIR domains	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21959264	2011	Pubchem Assay
PRRID_0921	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS was also shown to play a role in alloimmune lung injury	Toll-like receptor 4/MD-2 (TLR4/MD-2)	Toll-like receptor (TLR)	Mice	NA	intracellular TIR domains	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21959264	2011	Pubchem Assay

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