Detailed description page of PRRDB2.0

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PRRID_0662 details
Primary information
PRRIDPRRID_0662
Ligand NameLoxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)
SourceGuanosine (others)
Sequence of ligandC=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O
LengthNA
TypeNucleic Acid
OccurenceSynthetic
Role of LigandIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12
Name of receptorToll-like receptor 8 (TLR8)
Type of receptorToll-like receptor (TLR)
Source Human
LocalizationDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells
DomainLeucine-rich Repeat (LRR) Domain
Sequence of ReceptorQ9NR97.fasta
Swiss prot IDQ9NR97
Length Of Receptor1041
FunctionItresults into the inflammatory response
Assay usedNA
PMID20713100
Year of Publication2010
Pubchem assayPubchem Assay
Primary information
PRRIDPRRID_0662
Ligand NameLoxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)
SourceGuanosine (others)
Sequence of ligandC=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O
LengthNA
TypeNucleic Acid
OccurenceSynthetic
Role of LigandIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12
Name of receptorToll-like receptor 8 (TLR8)
Type of receptorToll-like receptor (TLR)
Source Human
LocalizationDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells
DomainLeucine-rich Repeat (LRR) Domain
Sequence of ReceptorQ9NR97.fasta
Swiss prot IDQ9NR97
Length Of Receptor1041
FunctionItresults into the inflammatory response
Assay usedNA
PMID20713100
Year of Publication2010
Pubchem assayPubchem Assay