Detailed description page of PRRDB2.0

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PRRID_0660 details
Primary information
PRRIDPRRID_0660
Ligand NameLow Molecular Weight Hyaluronic Acid (LMW-HA)
Sourcehuman umbilical cord (others)
Sequence of ligandCC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O
LengthNA
TypeEndogenous
OccurenceSynthetic
Role of LigandBinding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokines
Name of receptorToll-like receptor 2 (TLR2)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationembryonic mouse telencephalon and NPC
DomainLeucine-rich Repeat (LRR) Domain
Sequence of ReceptorQ9QUN7.fasta
Swiss prot IDQ9QUN7
Length Of Receptor784
Functionits activation inhibits NPC proliferation and decreases cell proliferation.
Assay usedNA
PMID20456021
Year of Publication2010
Pubchem assayPubchem Assay
Primary information
PRRIDPRRID_0660
Ligand NameLow Molecular Weight Hyaluronic Acid (LMW-HA)
Sourcehuman umbilical cord (others)
Sequence of ligandCC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O
LengthNA
TypeEndogenous
OccurenceSynthetic
Role of LigandBinding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokines
Name of receptorToll-like receptor 2 (TLR2)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationembryonic mouse telencephalon and NPC
DomainLeucine-rich Repeat (LRR) Domain
Sequence of ReceptorQ9QUN7.fasta
Swiss prot IDQ9QUN7
Length Of Receptor784
Functionits activation inhibits NPC proliferation and decreases cell proliferation.
Assay usedNA
PMID20456021
Year of Publication2010
Pubchem assayPubchem Assay