| Primary information |
|---|
| PRRID | PRRID_0660 |
| Ligand Name | Low Molecular Weight Hyaluronic Acid (LMW-HA) |
| Source | human umbilical cord (others) |
| Sequence of ligand | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O |
| Length | NA |
| Type | Endogenous |
| Occurence | Synthetic |
| Role of Ligand | Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokines |
| Name of receptor | Toll-like receptor 2 (TLR2) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Mice |
| Localization | embryonic mouse telencephalon and NPC |
| Domain | Leucine-rich Repeat (LRR) Domain |
| Sequence of Receptor | Q9QUN7.fasta |
| Swiss prot ID | Q9QUN7 |
| Length Of Receptor | 784 |
| Function | its activation inhibits NPC proliferation and decreases cell proliferation. |
| Assay used | NA |
| PMID | 20456021 |
| Year of Publication | 2010 |
| Pubchem assay | Pubchem Assay |
| Primary information |
|---|
| PRRID | PRRID_0660 |
| Ligand Name | Low Molecular Weight Hyaluronic Acid (LMW-HA) |
| Source | human umbilical cord (others) |
| Sequence of ligand | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O |
| Length | NA |
| Type | Endogenous |
| Occurence | Synthetic |
| Role of Ligand | Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokines |
| Name of receptor | Toll-like receptor 2 (TLR2) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Mice |
| Localization | embryonic mouse telencephalon and NPC |
| Domain | Leucine-rich Repeat (LRR) Domain |
| Sequence of Receptor | Q9QUN7.fasta |
| Swiss prot ID | Q9QUN7 |
| Length Of Receptor | 784 |
| Function | its activation inhibits NPC proliferation and decreases cell proliferation. |
| Assay used | NA |
| PMID | 20456021 |
| Year of Publication | 2010 |
| Pubchem assay | Pubchem Assay |