Primary information |
---|
PRRID | PRRID_0660 |
Ligand Name | Low Molecular Weight Hyaluronic Acid (LMW-HA) |
Source | human umbilical cord (others) |
Sequence of ligand | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O |
Length | NA |
Type | Endogenous |
Occurence | Synthetic |
Role of Ligand | Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokines |
Name of receptor | Toll-like receptor 2 (TLR2) |
Type of receptor | Toll-like receptor (TLR) |
Source | Mice |
Localization | embryonic mouse telencephalon and NPC |
Domain | Leucine-rich Repeat (LRR) Domain |
Sequence of Receptor | Q9QUN7.fasta |
Swiss prot ID | Q9QUN7 |
Length Of Receptor | 784 |
Function | its activation inhibits NPC proliferation and decreases cell proliferation. |
Assay used | NA |
PMID | 20456021 |
Year of Publication | 2010 |
Pubchem assay | Pubchem Assay |
Primary information |
---|
PRRID | PRRID_0660 |
Ligand Name | Low Molecular Weight Hyaluronic Acid (LMW-HA) |
Source | human umbilical cord (others) |
Sequence of ligand | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O |
Length | NA |
Type | Endogenous |
Occurence | Synthetic |
Role of Ligand | Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokines |
Name of receptor | Toll-like receptor 2 (TLR2) |
Type of receptor | Toll-like receptor (TLR) |
Source | Mice |
Localization | embryonic mouse telencephalon and NPC |
Domain | Leucine-rich Repeat (LRR) Domain |
Sequence of Receptor | Q9QUN7.fasta |
Swiss prot ID | Q9QUN7 |
Length Of Receptor | 784 |
Function | its activation inhibits NPC proliferation and decreases cell proliferation. |
Assay used | NA |
PMID | 20456021 |
Year of Publication | 2010 |
Pubchem assay | Pubchem Assay |