Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0589IMO-3

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NA5'-TCAGToCG2TTAC-Z-CATTG2CoTGACT-5'NANucleic AcidSyntheticBinding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-3Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceHEK293 cells, Bcells, PDCs, mDCs, PBMCLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032This has immunostimulatory effectCytokines assay203810192010Pubchem Assay
PRRID_0589IMO-3

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NA5'-TCAGToCG2TTAC-Z-CATTG2CoTGACT-5'NANucleic AcidSyntheticBinding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-3Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceHEK293 cells, Bcells, PDCs, mDCs, PBMCLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032This has immunostimulatory effectCytokines assay203810192010Pubchem Assay
PRRID_0590IMO-4

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NA5'-TCTGoToCG2TTAG-M-GATTG2CoToGTCT-5'NANucleic AcidSyntheticBinding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-4Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceHEK293 cells, Bcells, PDCs, mDCs, PBMCLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032This has immunostimulatory effectCytokines assay203810192010Pubchem Assay
PRRID_0590IMO-4

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NA5'-TCTGoToCG2TTAG-M-GATTG2CoToGTCT-5'NANucleic AcidSyntheticBinding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-4Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceHEK293 cells, Bcells, PDCs, mDCs, PBMCLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032This has immunostimulatory effectCytokines assay203810192010Pubchem Assay
PRRID_0591IMO-5

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NA5'-CAGTCoG2TTCAG-Z-GACTTG2oCTGAC-5'NANucleic AcidSyntheticBinding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-5Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceHEK293 cells, Bcells, PDCs, mDCs, PBMCLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032This has immunostimulatory effectCytokines assay203810192010Pubchem Assay
PRRID_0591IMO-5

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NA5'-CAGTCoG2TTCAG-Z-GACTTG2oCTGAC-5'NANucleic AcidSyntheticBinding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-5Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceHEK293 cells, Bcells, PDCs, mDCs, PBMCLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032This has immunostimulatory effectCytokines assay203810192010Pubchem Assay
PRRID_0592IMO-6

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NA5'-TCG1TCG1TTTY-M-YTTTG1CTG1CT-5'NANucleic AcidSyntheticBinding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-6Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceHEK293 cells, Bcells, PDCs, mDCs, PBMCLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032This has immunostimulatory effectCytokines assay203810192010Pubchem Assay
PRRID_0592IMO-6

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NA5'-TCG1TCG1TTTY-M-YTTTG1CTG1CT-5'NANucleic AcidSyntheticBinding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-6Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceHEK293 cells, Bcells, PDCs, mDCs, PBMCLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032This has immunostimulatory effectCytokines assay203810192010Pubchem Assay
PRRID_0593IMO-7

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NA5'-TCG1TCG1TTTY-X-YTTTG1CTG1CT-5'NANucleic AcidSyntheticBinding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-7Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceHEK293 cells, Bcells, PDCs, mDCs, PBMCLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032This has immunostimulatory effectCytokines assay203810192010Pubchem Assay
PRRID_0593IMO-7

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NA5'-TCG1TCG1TTTY-X-YTTTG1CTG1CT-5'NANucleic AcidSyntheticBinding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-7Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceHEK293 cells, Bcells, PDCs, mDCs, PBMCLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032This has immunostimulatory effectCytokines assay203810192010Pubchem Assay
PRRID_0594IMO-8

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NA 5'-TCG1TCG1TTTUU-X-UUTTTG1CTG1CT-5'NANucleic AcidSyntheticBinding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-8Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceHEK293 cells, Bcells, PDCs, mDCs, PBMCLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032This has immunostimulatory effectCytokines assay203810192010Pubchem Assay
PRRID_0594IMO-8

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NA 5'-TCG1TCG1TTTUU-X-UUTTTG1CTG1CT-5'NANucleic AcidSyntheticBinding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-8Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceHEK293 cells, Bcells, PDCs, mDCs, PBMCLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032This has immunostimulatory effectCytokines assay203810192010Pubchem Assay
PRRID_0595IMO-9

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NA 5'-TCG1TCG1TTdUY-Z-YdUTTG1CTG1CT-5'NANucleic AcidSyntheticBinding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-9Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceHEK293 cells, Bcells, PDCs, mDCs, PBMCLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032This has immunostimulatory effectCytokines assay203810192010Pubchem Assay
PRRID_0595IMO-9

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NA 5'-TCG1TCG1TTdUY-Z-YdUTTG1CTG1CT-5'NANucleic AcidSyntheticBinding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-9Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceHEK293 cells, Bcells, PDCs, mDCs, PBMCLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032This has immunostimulatory effectCytokines assay203810192010Pubchem Assay
PRRID_0596intranigral Lipopolysaccharide (LPS) injection

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exogenous (others)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)PD animal modelmicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It upregulates proinflammatory cytokines and free radical production, leads to dopaminergic cell death.NA207066422010Pubchem Assay
PRRID_0596intranigral Lipopolysaccharide (LPS) injection

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exogenous (others)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)PD animal modelmicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It upregulates proinflammatory cytokines and free radical production, leads to dopaminergic cell death.NA207066422010Pubchem Assay
PRRID_0599Korean mistletoe lectin (KML-C)

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Korean mistletoe (Viscum album coloratum) (plant)NANALectinNaturalBinding leads to the upregulation of interleukin-1 receptor-associated kinase-1 (IRAK1), resulting in macrophage activation and TNF-a production.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacropahgesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835KML-C has strong immunomodulatory effects, such as immune cell activation and cytokine induction, which results in antitumor activities or protection from microbial infections.ELISA204508852010Pubchem Assay
PRRID_0599Korean mistletoe lectin (KML-C)

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Korean mistletoe (Viscum album coloratum) (plant)NANALectinNaturalBinding leads to the upregulation of interleukin-1 receptor-associated kinase-1 (IRAK1), resulting in macrophage activation and TNF-a production.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacropahgesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835KML-C has strong immunomodulatory effects, such as immune cell activation and cytokine induction, which results in antitumor activities or protection from microbial infections.ELISA204508852010Pubchem Assay
PRRID_0600Lactoferrin

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Human (others)MKLVFLVLLFLGALGLCLAGRRRRSVQWCAVSQPEATKCFQWQRNMRRVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRNAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAEDAGDVAFVKGVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK711GlycoproteinNaturalIt activates the NF-Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanhuman monocytic leukemia cell line, THP-1LRRO00206.fastaO00206839It has a immunostimulatory roleEMSA203459052010Pubchem Assay
PRRID_0600Lactoferrin

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Human (others)MKLVFLVLLFLGALGLCLAGRRRRSVQWCAVSQPEATKCFQWQRNMRRVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRNAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAEDAGDVAFVKGVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK711GlycoproteinNaturalIt activates the NF-Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanhuman monocytic leukemia cell line, THP-1LRRO00206.fastaO00206839It has a immunostimulatory roleEMSA203459052010Pubchem Assay
PRRID_0601LAM

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Mycobacteria (Bacteria)OC[C@H]1O[C@@H](S[C@H]2[C@H](O)[C@@H](CO)O[C@@H](O[C@@H]3[C@H](O)[C@@H](CO)O[C@H](Oc4ccc(cc4)[N+]([O-])=O)[C@@H]3O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1ONAPattern-associated molecular patterns (PAMPs)NaturalIncreases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceLung's endothelial cellLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It has the role in the inflammation.NA207066582010Pubchem Assay
PRRID_0601LAM

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Mycobacteria (Bacteria)OC[C@H]1O[C@@H](S[C@H]2[C@H](O)[C@@H](CO)O[C@@H](O[C@@H]3[C@H](O)[C@@H](CO)O[C@H](Oc4ccc(cc4)[N+]([O-])=O)[C@@H]3O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1ONAPattern-associated molecular patterns (PAMPs)NaturalIncreases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceLung's endothelial cellLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It has the role in the inflammation.NA207066582010Pubchem Assay
PRRID_0602lentinan

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Lentinus edodes (fungi)C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)O)O)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)CO)O)OC5C(C(C(C(O5)COC6C(C(C(C(O6)CO)O)O)O)O)OC7C(C(C(C(O7)CO)O)O)O)O)O)O)O)O)O)O)ONABiological response modifiers (BRMs)NaturalMedicinal propertiesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micedendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835used clinically for cancer therapyNA206991312010Pubchem Assay
PRRID_0602lentinan

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Lentinus edodes (fungi)C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)O)O)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)CO)O)OC5C(C(C(C(O5)COC6C(C(C(C(O6)CO)O)O)O)O)OC7C(C(C(C(O7)CO)O)O)O)O)O)O)O)O)O)O)ONABiological response modifiers (BRMs)NaturalMedicinal propertiesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micedendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835used clinically for cancer therapyNA206991312010Pubchem Assay
PRRID_0604lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0604lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0605lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay
PRRID_0605lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay
PRRID_0607lipomannas

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M. tuberculosis (Bacteria)NANAGlycolipidNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0607lipomannas

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M. tuberculosis (Bacteria)NANAGlycolipidNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0608Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalK63-linked ubiquitination of Beclin1 using TRAF6 and A20 and triggered autophagyToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)Plasma MembraneLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It leads to autophagy and hence clearance of the pathogenNA207986082010Pubchem Assay
PRRID_0608Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalK63-linked ubiquitination of Beclin1 using TRAF6 and A20 and triggered autophagyToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)Plasma MembraneLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It leads to autophagy and hence clearance of the pathogenNA207986082010Pubchem Assay
PRRID_0609Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalOn binding to the receptor it leads to the release of an array of cytokinesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)P815 cellsNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784Immunostimulation and inflammationNA207985182010Pubchem Assay
PRRID_0609Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalOn binding to the receptor it leads to the release of an array of cytokinesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)P815 cellsNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784Immunostimulation and inflammationNA207985182010Pubchem Assay
PRRID_0610Lipopolysaccharide (LPS)

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M. tuberculosis (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS is a potent activator of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)DNA samples from peripheral blood of TB patientsNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Immunostimulation and inflammationNA207979052010Pubchem Assay
PRRID_0610Lipopolysaccharide (LPS)

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M. tuberculosis (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS is a potent activator of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)DNA samples from peripheral blood of TB patientsNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Immunostimulation and inflammationNA207979052010Pubchem Assay
PRRID_0611Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0611Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0612Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalSecretion of proinflammatory cytokines such as TFG-β and IL-6Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)DF-MSCs & DP-MSCsToothLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207315362010Pubchem Assay
PRRID_0612Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalSecretion of proinflammatory cytokines such as TFG-β and IL-6Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)DF-MSCs & DP-MSCsToothLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207315362010Pubchem Assay
PRRID_0613Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLipopolysaccharides are the potent activators of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)stage 3-4 CKD and HD patientsCD14+ MonocytesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Immunostimulation and inflammationNA207292662010Pubchem Assay
PRRID_0613Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLipopolysaccharides are the potent activators of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)stage 3-4 CKD and HD patientsCD14+ MonocytesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Immunostimulation and inflammationNA207292662010Pubchem Assay
PRRID_0614Lipopolysaccharide (LPS)

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S. aureus (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLipopolysaccharides are the potent activators of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)C57BL/6 MiceMacropahgesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835Contributes to inflammatory responses induced by orthopaedic wear particles in cell culture and murine models of aseptic loosening of orthopaedic implantsNA207292142010Pubchem Assay
PRRID_0614Lipopolysaccharide (LPS)

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S. aureus (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLipopolysaccharides are the potent activators of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)C57BL/6 MiceMacropahgesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835Contributes to inflammatory responses induced by orthopaedic wear particles in cell culture and murine models of aseptic loosening of orthopaedic implantsNA207292142010Pubchem Assay
PRRID_0615Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLps is a potent activator of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanKeratinocytesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207289392010Pubchem Assay
PRRID_0615Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLps is a potent activator of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanKeratinocytesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207289392010Pubchem Assay
PRRID_0616Lipopolysaccharide (LPS)

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Escherichia coli O111: B4 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBCAP-L is a negative regulator of TLR signaling-induced production of IL-6 and IL10 but not TNF-a in macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicemacrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It has the role in the inflammation.NA207284332010Pubchem Assay
PRRID_0616Lipopolysaccharide (LPS)

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Escherichia coli O111: B4 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBCAP-L is a negative regulator of TLR signaling-induced production of IL-6 and IL10 but not TNF-a in macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicemacrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It has the role in the inflammation.NA207284332010Pubchem Assay
PRRID_0617Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalReduced HIV-1 expression and cell toxicity in macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leads to the clearance of the pathogen from the systemNA207199932010Pubchem Assay
PRRID_0617Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalReduced HIV-1 expression and cell toxicity in macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leads to the clearance of the pathogen from the systemNA207199932010Pubchem Assay
PRRID_0618Lipopolysaccharide (LPS)

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Salmonella minnesota (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 Asp299Gly (TLR-4 Asp299Gly)Toll-like receptor (TLR)FMF patientsmonocytes and granulocytesLeucine-rich Repeat (LRR) DomainNANANADownregulate inflammation in FMF patientsNA207147962010NA
PRRID_0618Lipopolysaccharide (LPS)

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Salmonella minnesota (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 Asp299Gly (TLR-4 Asp299Gly)Toll-like receptor (TLR)FMF patientsmonocytes and granulocytesLeucine-rich Repeat (LRR) DomainNANANADownregulate inflammation in FMF patientsNA207147962010NA
PRRID_0619Lipopolysaccharide (LPS)

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Salmonella minnesota (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR-4 Thre399Ile)Toll-like receptor (TLR)FMF patientsmonocytes and granulocytesLeucine-rich Repeat (LRR) DomainNANANADownregulate inflammation in FMF patientsNA207147962010NA
PRRID_0619Lipopolysaccharide (LPS)

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Salmonella minnesota (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR-4 Thre399Ile)Toll-like receptor (TLR)FMF patientsmonocytes and granulocytesLeucine-rich Repeat (LRR) DomainNANANADownregulate inflammation in FMF patientsNA207147962010NA
PRRID_0620Lipopolysaccharide (LPS)

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Bacterial strainsCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0620Lipopolysaccharide (LPS)

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Bacterial strainsCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0621Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduces a signaling cascade that utilizes both the MyD88- and TRIF-dependent pathways, leading to NF-kB and IRF3/7 activationToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)dendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0621Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduces a signaling cascade that utilizes both the MyD88- and TRIF-dependent pathways, leading to NF-kB and IRF3/7 activationToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)dendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0622Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)New Zealand White rabbitsNALeucine-rich Repeat (LRR) DomainNANANAInvolvement of exogenous TLR ligands during arteriogenesisNA207086242010NA
PRRID_0622Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)New Zealand White rabbitsNALeucine-rich Repeat (LRR) DomainNANANAInvolvement of exogenous TLR ligands during arteriogenesisNA207086242010NA
PRRID_0623Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt produces various inflammatory cytokines including TNF-α, IL-1β, IL-6, IL-12, IL-18, and chemokines in granulomatous liver disease, ischemia/reperfusion liver injury, nonalcoholic steatohepatitis, and alcoholic liver diseaseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacropahgesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leads to the inflammation of the cellsNA207066772010Pubchem Assay
PRRID_0623Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt produces various inflammatory cytokines including TNF-α, IL-1β, IL-6, IL-12, IL-18, and chemokines in granulomatous liver disease, ischemia/reperfusion liver injury, nonalcoholic steatohepatitis, and alcoholic liver diseaseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacropahgesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leads to the inflammation of the cellsNA207066772010Pubchem Assay
PRRID_0624Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt produces a large amount of glutamate, an important neurotransmitter but also a potent neurotoxin and is linked to oligodendrocyte injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835produce a large amount of glutamate, an important neurotransmitter but also a potent neurotoxin and is linked to oligodendrocyte injuryNA207066422010Pubchem Assay
PRRID_0624Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt produces a large amount of glutamate, an important neurotransmitter but also a potent neurotoxin and is linked to oligodendrocyte injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835produce a large amount of glutamate, an important neurotransmitter but also a potent neurotoxin and is linked to oligodendrocyte injuryNA207066422010Pubchem Assay
PRRID_0625Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanneuronsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It induces the expression of nociceptin, an opioid-related neuropeptideNA207066422010Pubchem Assay
PRRID_0625Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanneuronsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It induces the expression of nociceptin, an opioid-related neuropeptideNA207066422010Pubchem Assay
PRRID_0626Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanMicrogliaLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858It causes profound microglial activation associated with oligodendrocyte death, demyelination, and increased vulnerability of neurons to injuryNA207066422010Pubchem Assay
PRRID_0626Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanMicrogliaLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858It causes profound microglial activation associated with oligodendrocyte death, demyelination, and increased vulnerability of neurons to injuryNA207066422010Pubchem Assay
PRRID_0627Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)CNSNALeucine-rich Repeat (LRR) DomainNANANAIt cause severe loss of dopamine neurons in the substantia nigra and neurons in the hippocampusNA207066422010NA
PRRID_0627Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)CNSNALeucine-rich Repeat (LRR) DomainNANANAIt cause severe loss of dopamine neurons in the substantia nigra and neurons in the hippocampusNA207066422010NA
PRRID_0628Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)AD Mice's hippocampusmicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835Involved in the clearance of Aβ deposits in the brainNA207066422010Pubchem Assay
PRRID_0628Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)AD Mice's hippocampusmicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835Involved in the clearance of Aβ deposits in the brainNA207066422010Pubchem Assay
PRRID_0629Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduced the secretion of IL-6 and IL-9Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanperipheral mononuclear cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207031562010Pubchem Assay
PRRID_0629Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduced the secretion of IL-6 and IL-9Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanperipheral mononuclear cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207031562010Pubchem Assay
PRRID_0632Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)RatmyocardiumLeucine-rich Repeat (LRR) DomainQ9QX05.fastaQ9QX05835NANA206975482010Pubchem Assay
PRRID_0632Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)RatmyocardiumLeucine-rich Repeat (LRR) DomainQ9QX05.fastaQ9QX05835NANA206975482010Pubchem Assay
PRRID_0636Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalThe binding results into secretion of low amounts of IL-12(p70) and high levels of IL-10 ompared with adult cellsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCord blood cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA206360302010Pubchem Assay
PRRID_0636Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalThe binding results into secretion of low amounts of IL-12(p70) and high levels of IL-10 ompared with adult cellsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCord blood cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA206360302010Pubchem Assay
PRRID_0637Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS treatment of fibroblasts induced IκBα degradation, enhanced NFκB promoter activity and increased collagen contractionToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanIntestinal FibroblastsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It induces collagen contraction and reduces the expression of the TGF-β1 inhibitor, smad-7 which results in intestinal injury following injury.Luciferase assay206322822010Pubchem Assay
PRRID_0637Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS treatment of fibroblasts induced IκBα degradation, enhanced NFκB promoter activity and increased collagen contractionToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanIntestinal FibroblastsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It induces collagen contraction and reduces the expression of the TGF-β1 inhibitor, smad-7 which results in intestinal injury following injury.Luciferase assay206322822010Pubchem Assay
PRRID_0638Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leadsto the secretion of the proinfalmmatory cytokines and IFN-βNA206201292010Pubchem Assay
PRRID_0638Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leadsto the secretion of the proinfalmmatory cytokines and IFN-βNA206201292010Pubchem Assay
PRRID_0640Lipopolysaccharide (LPS)

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Escherichia coli serotype 0127:B9 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBinding of LPS trigger the NFKB pathway and inducing a local synthesis of the cytokine TNF, and the TNF receptor 1 (TNFR1) up-regulation in pinealocytesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Wistar RatPineal gland (pinealocytes)Leucine-rich Repeat (LRR) DomainQ9QX05.fastaQ9QX05835The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF by inhibiting the NE-induced melatonin biosynthetic pathway and mount the inflammatory responseEMSA205868882010Pubchem Assay
PRRID_0640Lipopolysaccharide (LPS)

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Escherichia coli serotype 0127:B9 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBinding of LPS trigger the NFKB pathway and inducing a local synthesis of the cytokine TNF, and the TNF receptor 1 (TNFR1) up-regulation in pinealocytesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Wistar RatPineal gland (pinealocytes)Leucine-rich Repeat (LRR) DomainQ9QX05.fastaQ9QX05835The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF by inhibiting the NE-induced melatonin biosynthetic pathway and mount the inflammatory responseEMSA205868882010Pubchem Assay
PRRID_0641Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt's binding induces the production of IL6, IL8, MMP3 and MMP2Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanFibroblast Like Synoviocytes (FLS)Leucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destructionELISA205711652010Pubchem Assay
PRRID_0641Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt's binding induces the production of IL6, IL8, MMP3 and MMP2Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanFibroblast Like Synoviocytes (FLS)Leucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destructionELISA205711652010Pubchem Assay
PRRID_0644Lipopolysaccharide (LPS)

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Escherichia coli strain 0111:B4 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt induces the release of microparticles by the macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)MacropahesLRRQ9QUK6.fastaQ9QUK6835It leads to the release of MPs which act as the novel signals for innate immunityGriess assay203353122010Pubchem Assay
PRRID_0644Lipopolysaccharide (LPS)

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Escherichia coli strain 0111:B4 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt induces the release of microparticles by the macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)MacropahesLRRQ9QUK6.fastaQ9QUK6835It leads to the release of MPs which act as the novel signals for innate immunityGriess assay203353122010Pubchem Assay
PRRID_0645Lipopolysaccharide (LPS)

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Aspergillus fumigatus(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt induces the secretion of IL-6, IL-8, CC chemokine-ligand 20 (CCL20) and thymosin β4 (Tβ4).Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanTelomerase-Immortalized Human Stroma Fibroblasts (THSFs)NAO00206.fastaO00206839It has the immunostimulatory role.ELISA203050392010Pubchem Assay
PRRID_0645Lipopolysaccharide (LPS)

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Aspergillus fumigatus(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt induces the secretion of IL-6, IL-8, CC chemokine-ligand 20 (CCL20) and thymosin β4 (Tβ4).Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanTelomerase-Immortalized Human Stroma Fibroblasts (THSFs)NAO00206.fastaO00206839It has the immunostimulatory role.ELISA203050392010Pubchem Assay
PRRID_0646Lipoprotein

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Staphylococcus epidermis & aureus (Bacteria)NANALipoproteinNaturalTLR-2 mediated by the NF-kB pathway in septic arthritic chondrocytes and cytokine productionToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Septic Chondrocytes from homo sapiensNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Immunostimulation and inflammationNA207406732010Pubchem Assay
PRRID_0646Lipoprotein

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Staphylococcus epidermis & aureus (Bacteria)NANALipoproteinNaturalTLR-2 mediated by the NF-kB pathway in septic arthritic chondrocytes and cytokine productionToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Septic Chondrocytes from homo sapiensNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Immunostimulation and inflammationNA207406732010Pubchem Assay
PRRID_0647Lipoprotein

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M. tuberculosis (Bacteria)NANALipoproteinNaturalLipoprotein binds to the TLR2 and activates the downstream cascadesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207292072010Pubchem Assay
PRRID_0647Lipoprotein

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M. tuberculosis (Bacteria)NANALipoproteinNaturalLipoprotein binds to the TLR2 and activates the downstream cascadesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207292072010Pubchem Assay
PRRID_0648NS3

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Hepatitis C Virus (virus)APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT631ProteinNaturalActivate MAP kinase pathway, NF-κB, and AP-1Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocytes and Kupffer cellsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Dysfunction of pDCs by enhanced production of IL-10 and TNF- αNA206720472010Pubchem Assay
PRRID_0648NS3

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Hepatitis C Virus (virus)APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT631ProteinNaturalActivate MAP kinase pathway, NF-κB, and AP-1Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocytes and Kupffer cellsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Dysfunction of pDCs by enhanced production of IL-10 and TNF- αNA206720472010Pubchem Assay
PRRID_0649Lipoprotein

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M. tuberculosis (Bacteria)NANALipoproteinNaturallipoprotein and lipoarabinomannan are the poteny activators of the TLR2Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)DNA samples from peripheral blood of TB patientsNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Immunostimulation and inflammationNA207979052010Pubchem Assay
PRRID_0649Lipoprotein

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M. tuberculosis (Bacteria)NANALipoproteinNaturallipoprotein and lipoarabinomannan are the poteny activators of the TLR2Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)DNA samples from peripheral blood of TB patientsNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Immunostimulation and inflammationNA207979052010Pubchem Assay
PRRID_0650Peptidoglycan (PGN)

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S. aureus (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalTheir binding to the TLR2 leads to the activation of the downstream signallingToll-like receptor 2 (TLR2)Toll-like receptor (TLR)C57/BL Mice cell lineNALeucine-rich Repeat (LRR) DomainO53505.fastaO53505227maturation of the Dendritic cellsNA207953862010Pubchem Assay
PRRID_0650Peptidoglycan (PGN)

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S. aureus (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalTheir binding to the TLR2 leads to the activation of the downstream signallingToll-like receptor 2 (TLR2)Toll-like receptor (TLR)C57/BL Mice cell lineNALeucine-rich Repeat (LRR) DomainO53505.fastaO53505227maturation of the Dendritic cellsNA207953862010Pubchem Assay