| Primary information |
|---|
| PRRID | PRRID_0596 |
| Ligand Name | intranigral Lipopolysaccharide (LPS) injection |
| Source | exogenous (others) |
| Sequence of ligand | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC |
| Length | NA |
| Type | Lipopolysaccharide (LPS) |
| Occurence | Synthetic |
| Role of Ligand | NA |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | PD animal model |
| Localization | microglia |
| Domain | Leucine-rich Repeat (LRR) Domain |
| Sequence of Receptor | Q9QUK6.fasta |
| Swiss prot ID | Q9QUK6 |
| Length Of Receptor | 835 |
| Function | It upregulates proinflammatory cytokines and free radical production, leads to dopaminergic cell death. |
| Assay used | NA |
| PMID | 20706642 |
| Year of Publication | 2010 |
| Pubchem assay | Pubchem Assay |
| Primary information |
|---|
| PRRID | PRRID_0596 |
| Ligand Name | intranigral Lipopolysaccharide (LPS) injection |
| Source | exogenous (others) |
| Sequence of ligand | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC |
| Length | NA |
| Type | Lipopolysaccharide (LPS) |
| Occurence | Synthetic |
| Role of Ligand | NA |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | PD animal model |
| Localization | microglia |
| Domain | Leucine-rich Repeat (LRR) Domain |
| Sequence of Receptor | Q9QUK6.fasta |
| Swiss prot ID | Q9QUK6 |
| Length Of Receptor | 835 |
| Function | It upregulates proinflammatory cytokines and free radical production, leads to dopaminergic cell death. |
| Assay used | NA |
| PMID | 20706642 |
| Year of Publication | 2010 |
| Pubchem assay | Pubchem Assay |