Detailed description page of PRRDB2.0

This page displays user query in tabular form.

PRRID_0640 details
Primary information
PRRIDPRRID_0640
Ligand NameLipopolysaccharide (LPS)
SourceEscherichia coli serotype 0127:B9 (Bacteria)
Sequence of ligandCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC
LengthNA
TypeLipopolysaccharide (LPS)
OccurenceNatural
Role of LigandBinding of LPS trigger the NFKB pathway and inducing a local synthesis of the cytokine TNF, and the TNF receptor 1 (TNFR1) up-regulation in pinealocytes
Name of receptorToll-like receptor 4 (TLR4)
Type of receptorToll-like receptor (TLR)
Source Wistar Rat
LocalizationPineal gland (pinealocytes)
DomainLeucine-rich Repeat (LRR) Domain
Sequence of ReceptorQ9QX05.fasta
Swiss prot IDQ9QX05
Length Of Receptor835
FunctionThe pineal gland transduces Gram-negative endotoxin stimulation by producing TNF by inhibiting the NE-induced melatonin biosynthetic pathway and mount the inflammatory response
Assay usedEMSA
PMID20586888
Year of Publication2010
Pubchem assayPubchem Assay
Primary information
PRRIDPRRID_0640
Ligand NameLipopolysaccharide (LPS)
SourceEscherichia coli serotype 0127:B9 (Bacteria)
Sequence of ligandCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC
LengthNA
TypeLipopolysaccharide (LPS)
OccurenceNatural
Role of LigandBinding of LPS trigger the NFKB pathway and inducing a local synthesis of the cytokine TNF, and the TNF receptor 1 (TNFR1) up-regulation in pinealocytes
Name of receptorToll-like receptor 4 (TLR4)
Type of receptorToll-like receptor (TLR)
Source Wistar Rat
LocalizationPineal gland (pinealocytes)
DomainLeucine-rich Repeat (LRR) Domain
Sequence of ReceptorQ9QX05.fasta
Swiss prot IDQ9QX05
Length Of Receptor835
FunctionThe pineal gland transduces Gram-negative endotoxin stimulation by producing TNF by inhibiting the NE-induced melatonin biosynthetic pathway and mount the inflammatory response
Assay usedEMSA
PMID20586888
Year of Publication2010
Pubchem assayPubchem Assay