| Role of Ligand | LTA-treated LEC increases the expression of E-selectin, ICAM-1, and VCAM-1, moreover it induces the expression of CCL2, CCL5, and CCL20 (Cys-Cys motif chemokines) and of CXCL1, CXCL3, CXCL5, CXCL6, and CXCL8 (Cys-X-Cys motif chemokines). |
| Primary information |
|---|
| PRRID | PRRID_0316 |
| Ligand Name | Lipoteichoic Acid (LTA) |
| Source | Bacillus subtilis(Bacteria) |
| Sequence of ligand | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O |
| Length | NA |
| Type | Amphiphile |
| Occurence | Natural |
| Role of Ligand | LTA-treated LEC increases the expression of E-selectin, ICAM-1, and VCAM-1, moreover it induces the expression of CCL2, CCL5, and CCL20 (Cys-Cys motif chemokines) and of CXCL1, CXCL3, CXCL5, CXCL6, and CXCL8 (Cys-X-Cys motif chemokines). |
| Name of receptor | Toll-like receptor 2 (TLR2) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | Cultured human lymphatic endothelium (LEC) |
| Domain | LRR |
| Sequence of Receptor | O60603.fasta |
| Swiss prot ID | O60603 |
| Length Of Receptor | 784 |
| Function | It has a immunostimulatory role |
| Assay used | ELISA |
| PMID | 18523807 |
| Year of Publication | 2008 |
| Pubchem assay | Pubchem Assay |