| Primary information |
|---|
| PRRID | PRRID_0305 |
| Ligand Name | Lipopolysaccharide (LPS) |
| Source | E. coli 055:B5(Bacteria) |
| Sequence of ligand | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC |
| Length | NA |
| Type | Lipopolysaccharide (LPS) |
| Occurence | Natural |
| Role of Ligand | LPS promotes TGFb1 and VEGF production in human prostate epithelial PC3 cells and also LPS stimulation, leads to the increased expression of NF-KB p65 protein. |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | Human prostate epithelial PC3 cells |
| Domain | LRR |
| Sequence of Receptor | O00206.fasta |
| Swiss prot ID | O00206 |
| Length Of Receptor | 839 |
| Function | It plays important roles in promoting prostate cancer immune escape, survival, progression, and metastasis by inducing immunosuppressive and proangiogenic cytokines. |
| Assay used | ELISA |
| PMID | 18649875 |
| Year of Publication | 2008 |
| Pubchem assay | Pubchem Assay |
| Primary information |
|---|
| PRRID | PRRID_0305 |
| Ligand Name | Lipopolysaccharide (LPS) |
| Source | E. coli 055:B5(Bacteria) |
| Sequence of ligand | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC |
| Length | NA |
| Type | Lipopolysaccharide (LPS) |
| Occurence | Natural |
| Role of Ligand | LPS promotes TGFb1 and VEGF production in human prostate epithelial PC3 cells and also LPS stimulation, leads to the increased expression of NF-KB p65 protein. |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | Human prostate epithelial PC3 cells |
| Domain | LRR |
| Sequence of Receptor | O00206.fasta |
| Swiss prot ID | O00206 |
| Length Of Receptor | 839 |
| Function | It plays important roles in promoting prostate cancer immune escape, survival, progression, and metastasis by inducing immunosuppressive and proangiogenic cytokines. |
| Assay used | ELISA |
| PMID | 18649875 |
| Year of Publication | 2008 |
| Pubchem assay | Pubchem Assay |