Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0501FasL

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Endogenous (others)MQQPMNYPCPQIFWVDSSATSSWAPPGSVFPCPSCGPRGPDQRRPPPPPPPVSPLPPPSQPLPLPPLTPLKKKDHNTNLWLPVVFFMVLVALVGMGLGMYQLFHLQKELAELREFTNQSLKVSSFEKQIANPSTPSEKKEPRSVAHLTGNPHSRSIPLEWEDTYGTALISGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNQPLNHKVYMRNSKYPEDLVLMEEKRLNYCTTGQIWAHSSYLGAVFNLTSADHLYVNISQLSLINFEESKTFFGLYKL279Pattern-associated molecular patterns (PAMPs)NaturalNAFasRPattern recognition receptor (PRR)Stevens-Johnson syndrome/toxic epidermal necrolysis patientsNANANANANAIt induce apoptosisNA207031562010NA
PRRID_0501FasL

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Endogenous (others)MQQPMNYPCPQIFWVDSSATSSWAPPGSVFPCPSCGPRGPDQRRPPPPPPPVSPLPPPSQPLPLPPLTPLKKKDHNTNLWLPVVFFMVLVALVGMGLGMYQLFHLQKELAELREFTNQSLKVSSFEKQIANPSTPSEKKEPRSVAHLTGNPHSRSIPLEWEDTYGTALISGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNQPLNHKVYMRNSKYPEDLVLMEEKRLNYCTTGQIWAHSSYLGAVFNLTSADHLYVNISQLSLINFEESKTFFGLYKL279Pattern-associated molecular patterns (PAMPs)NaturalNAFasRPattern recognition receptor (PRR)Stevens-Johnson syndrome/toxic epidermal necrolysis patientsNANANANANAIt induce apoptosisNA207031562010NA
PRRID_0539Glycosylphosphatidyl inositol anchor

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Protozoa (others)NANAPattern-associated molecular patterns (PAMPs)NaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0539Glycosylphosphatidyl inositol anchor

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Protozoa (others)NANAPattern-associated molecular patterns (PAMPs)NaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0540Glycosylphosphatidyl inositol anchor

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Trypanosoma Cruzi (others)NANAPattern-associated molecular patterns (PAMPs)NaturalIncreases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceLung's endothelial cellLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It has the role in the inflammation.NA207066582010Pubchem Assay
PRRID_0540Glycosylphosphatidyl inositol anchor

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Trypanosoma Cruzi (others)NANAPattern-associated molecular patterns (PAMPs)NaturalIncreases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceLung's endothelial cellLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It has the role in the inflammation.NA207066582010Pubchem Assay
PRRID_0543GPI anchor

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T. gondii (others)NANAPattern-associated molecular patterns (PAMPs)NaturalGPIs binds to the TLR2 and activaes the downstream processesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanmacrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Recognition and phagocytosisNA207292072010Pubchem Assay
PRRID_0543GPI anchor

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T. gondii (others)NANAPattern-associated molecular patterns (PAMPs)NaturalGPIs binds to the TLR2 and activaes the downstream processesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanmacrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Recognition and phagocytosisNA207292072010Pubchem Assay
PRRID_0573IL-4

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Endogenous (others)MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS137Pattern-associated molecular patterns (PAMPs)NaturalNAIL4RPattern recognition receptor (PRR)Stevens-Johnson syndrome/toxic epidermal necrolysis patientsNANAP24394.fastaP24394825NANA207031562010Pubchem Assay
PRRID_0573IL-4

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Endogenous (others)MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS137Pattern-associated molecular patterns (PAMPs)NaturalNAIL4RPattern recognition receptor (PRR)Stevens-Johnson syndrome/toxic epidermal necrolysis patientsNANAP24394.fastaP24394825NANA207031562010Pubchem Assay
PRRID_0601LAM

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Mycobacteria (Bacteria)OC[C@H]1O[C@@H](S[C@H]2[C@H](O)[C@@H](CO)O[C@@H](O[C@@H]3[C@H](O)[C@@H](CO)O[C@H](Oc4ccc(cc4)[N+]([O-])=O)[C@@H]3O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1ONAPattern-associated molecular patterns (PAMPs)NaturalIncreases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceLung's endothelial cellLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It has the role in the inflammation.NA207066582010Pubchem Assay
PRRID_0601LAM

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Mycobacteria (Bacteria)OC[C@H]1O[C@@H](S[C@H]2[C@H](O)[C@@H](CO)O[C@@H](O[C@@H]3[C@H](O)[C@@H](CO)O[C@H](Oc4ccc(cc4)[N+]([O-])=O)[C@@H]3O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1ONAPattern-associated molecular patterns (PAMPs)NaturalIncreases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceLung's endothelial cellLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It has the role in the inflammation.NA207066582010Pubchem Assay
PRRID_0685MPLA

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Salmonella minnesota R595 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONAPattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Rabbitdendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainG1SH24.fastaG1SH248391,000-fold less toxic than LPS and can be used as vaccinesNA207131002010Pubchem Assay
PRRID_0685MPLA

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Salmonella minnesota R595 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONAPattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Rabbitdendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainG1SH24.fastaG1SH248391,000-fold less toxic than LPS and can be used as vaccinesNA207131002010Pubchem Assay
PRRID_0686MPLA

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Salmonella minnesota R595 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONAPattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Guinea Pigdendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainH0VSQ0.fastaH0VSQ08371,000-fold less toxic than LPS and can be used as vaccinesNA207131002010Pubchem Assay
PRRID_0686MPLA

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Salmonella minnesota R595 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONAPattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Guinea Pigdendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainH0VSQ0.fastaH0VSQ08371,000-fold less toxic than LPS and can be used as vaccinesNA207131002010Pubchem Assay
PRRID_0687MPLA

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Salmonella minnesota R595 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONAPattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Dogsdendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainF1PDB9.fastaF1PDB98331,000-fold less toxic than LPS and can be used as vaccinesNA207131002010Pubchem Assay
PRRID_0687MPLA

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Salmonella minnesota R595 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONAPattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Dogsdendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainF1PDB9.fastaF1PDB98331,000-fold less toxic than LPS and can be used as vaccinesNA207131002010Pubchem Assay
PRRID_0688MPLA

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Salmonella minnesota R595 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONAPattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Horsedendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainF6RL35.fastaF6RL358431,000-fold less toxic than LPS and can be used as vaccinesNA207131002010Pubchem Assay
PRRID_0688MPLA

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Salmonella minnesota R595 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONAPattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Horsedendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainF6RL35.fastaF6RL358431,000-fold less toxic than LPS and can be used as vaccinesNA207131002010Pubchem Assay
PRRID_0701NA

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Acanthocheilonema viteae(others)NANAPattern-associated molecular patterns (PAMPs)NaturalNAScavenger receptor class AScavenger receptor (SR)Micelamina propria macrophageNAQ08857.fastaQ08857472It protect against microbial induced pregnancy lossNA207118462010Pubchem Assay
PRRID_0701NA

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Acanthocheilonema viteae(others)NANAPattern-associated molecular patterns (PAMPs)NaturalNAScavenger receptor class AScavenger receptor (SR)Micelamina propria macrophageNAQ08857.fastaQ08857472It protect against microbial induced pregnancy lossNA207118462010Pubchem Assay
PRRID_0702NA

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Acanthocheilonema viteae(others)NANAPattern-associated molecular patterns (PAMPs)NaturalNAScavenger receptor class AScavenger receptor (SR)Micelamina propria macrophageNAQ08857.fastaQ08857472It protect against microbial induced pregnancy lossNA207118462010Pubchem Assay
PRRID_0702NA

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Acanthocheilonema viteae(others)NANAPattern-associated molecular patterns (PAMPs)NaturalNAScavenger receptor class AScavenger receptor (SR)Micelamina propria macrophageNAQ08857.fastaQ08857472It protect against microbial induced pregnancy lossNA207118462010Pubchem Assay
PRRID_0812Surface structure

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VirusNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA207395192010Pubchem Assay
PRRID_0812Surface structure

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VirusNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)NALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784NANA207395192010Pubchem Assay
PRRID_0813Surface structure

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VirusNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)NALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA207395192010Pubchem Assay
PRRID_0813Surface structure

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VirusNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)NALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA207395192010Pubchem Assay
PRRID_0824Unknown

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P. syringae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalIt has role in disease resistance.CERK1Pattern recognition receptor (PRR)PlantsNANAA8R7E6.fastaA8R7E6617It has role in disease resistance.NA207139802010Pubchem Assay
PRRID_0824Unknown

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P. syringae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalIt has role in disease resistance.CERK1Pattern recognition receptor (PRR)PlantsNANAA8R7E6.fastaA8R7E6617It has role in disease resistance.NA207139802010Pubchem Assay
PRRID_0841Virus

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T. gondii (others)NANAPattern-associated molecular patterns (PAMPs)NaturalIt induces Crp-3/-5 production and release by PCs via a TLR9-dependent production of type I IFNsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)C57BL/6 Miceepithial cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It affect the early control of T. gondii invasiveness by promoting the initiation of a protective Th1 response against the parasiteNA204887912010Pubchem Assay
PRRID_0841Virus

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T. gondii (others)NANAPattern-associated molecular patterns (PAMPs)NaturalIt induces Crp-3/-5 production and release by PCs via a TLR9-dependent production of type I IFNsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)C57BL/6 Miceepithial cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It affect the early control of T. gondii invasiveness by promoting the initiation of a protective Th1 response against the parasiteNA204887912010Pubchem Assay
PRRID_0863LTA

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Gram-positive bacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalAugment cytokines and chemokines expression and promoting enhanced PMN transalveolar migration and exaggerated lung inflammation in response to invading pathogensToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceLung's endothelial cellLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It has the role in the inflammation.NA207066582010Pubchem Assay
PRRID_0863LTA

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Gram-positive bacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalAugment cytokines and chemokines expression and promoting enhanced PMN transalveolar migration and exaggerated lung inflammation in response to invading pathogensToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceLung's endothelial cellLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It has the role in the inflammation.NA207066582010Pubchem Assay
PRRID_0864β- 1,3-glucan

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Gram-negative bacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalNADmGNBP1Gram-negative Bacteria-binding Protein (GNBPs)Drosophila melanogasterNANAQ9NHB0.fastaQ9NHB0494It induces the proteolytic cascadeNA206991042010Pubchem Assay
PRRID_0864β- 1,3-glucan

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Gram-negative bacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalNADmGNBP1Gram-negative Bacteria-binding Protein (GNBPs)Drosophila melanogasterNANAQ9NHB0.fastaQ9NHB0494It induces the proteolytic cascadeNA206991042010Pubchem Assay
PRRID_0872Bropirimine

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NAC1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)BrNAPattern-associated molecular patterns (PAMPs)Syntheticexperimental drug with anti-cancer and antiviral propertiesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanB cells, dendritic cells, microglia, astrocytesNAQ9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA219825582011Pubchem Assay
PRRID_0872Bropirimine

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NAC1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)BrNAPattern-associated molecular patterns (PAMPs)Syntheticexperimental drug with anti-cancer and antiviral propertiesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanB cells, dendritic cells, microglia, astrocytesNAQ9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA219825582011Pubchem Assay
PRRID_0873Bropirimine

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NAC1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)BrNAPattern-associated molecular patterns (PAMPs)Syntheticexperimental drug with anti-cancer and antiviral propertiesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)NANANANANANATLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-α, IFN-β, TNF-α, and IL-13NA219554432011NA
PRRID_0873Bropirimine

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NAC1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)BrNAPattern-associated molecular patterns (PAMPs)Syntheticexperimental drug with anti-cancer and antiviral propertiesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)NANANANANANATLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-α, IFN-β, TNF-α, and IL-13NA219554432011NA
PRRID_0911iE-DAP (gamma-D-glutamyl-meso diaminopimelic acid)

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BacteriaN[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=ONAPattern-associated molecular patterns (PAMPs)Naturalpeptidoglycan substructuresNucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)HumanEosinophilsNAQ9Y239.fastaQ9Y239953play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.real-time reverse transcription-PCR, FACS, ELISA219780012011Pubchem Assay
PRRID_0911iE-DAP (gamma-D-glutamyl-meso diaminopimelic acid)

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BacteriaN[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=ONAPattern-associated molecular patterns (PAMPs)Naturalpeptidoglycan substructuresNucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)HumanEosinophilsNAQ9Y239.fastaQ9Y239953play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.real-time reverse transcription-PCR, FACS, ELISA219780012011Pubchem Assay
PRRID_0912Imidazoquinoline

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A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring CC1=C(NC(=C(C1=C2C=CC(=C(C2=O)OC)OC)N)C3=NC4=C(C=C3)C(=O)C(=C5C4=NC(N5)(C)C)OC)C(=O)ONAPattern-associated molecular patterns (PAMPs)SyntheticImidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergicToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanB cells, dendritic cells, microglia, astrocytesNAQ9NYK1.fastaQ9NYK11049TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-α, IFN-β, TNF-α, and IL-12 NA219825582011Pubchem Assay
PRRID_0912Imidazoquinoline

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A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring CC1=C(NC(=C(C1=C2C=CC(=C(C2=O)OC)OC)N)C3=NC4=C(C=C3)C(=O)C(=C5C4=NC(N5)(C)C)OC)C(=O)ONAPattern-associated molecular patterns (PAMPs)SyntheticImidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergicToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanB cells, dendritic cells, microglia, astrocytesNAQ9NYK1.fastaQ9NYK11049TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-α, IFN-β, TNF-α, and IL-12 NA219825582011Pubchem Assay
PRRID_0913Imidazoquinoline

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A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring CC1=C(NC(=C(C1=C2C=CC(=C(C2=O)OC)OC)N)C3=NC4=C(C=C3)C(=O)C(=C5C4=NC(N5)(C)C)OC)C(=O)ONAPattern-associated molecular patterns (PAMPs)SyntheticImidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergicToll-like receptor 7 (TLR7)Toll-like receptor (TLR)NANANANANANATLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-α, IFN-β, TNF-α, and IL-13NA219554432011NA
PRRID_0913Imidazoquinoline

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A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring CC1=C(NC(=C(C1=C2C=CC(=C(C2=O)OC)OC)N)C3=NC4=C(C=C3)C(=O)C(=C5C4=NC(N5)(C)C)OC)C(=O)ONAPattern-associated molecular patterns (PAMPs)SyntheticImidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergicToll-like receptor 7 (TLR7)Toll-like receptor (TLR)NANANANANANATLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-α, IFN-β, TNF-α, and IL-13NA219554432011NA
PRRID_0914Imidazoquinoline

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A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring CC1=C(NC(=C(C1=C2C=CC(=C(C2=O)OC)OC)N)C3=NC4=C(C=C3)C(=O)C(=C5C4=NC(N5)(C)C)OC)C(=O)ONAPattern-associated molecular patterns (PAMPs)SyntheticImidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergicToll-like receptor 8 (TLR8)Toll-like receptor (TLR)NANANANANANAimportant role in the immune response to viral infectionNA219554432011NA
PRRID_0914Imidazoquinoline

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A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring CC1=C(NC(=C(C1=C2C=CC(=C(C2=O)OC)OC)N)C3=NC4=C(C=C3)C(=O)C(=C5C4=NC(N5)(C)C)OC)C(=O)ONAPattern-associated molecular patterns (PAMPs)SyntheticImidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergicToll-like receptor 8 (TLR8)Toll-like receptor (TLR)NANANANANANAimportant role in the immune response to viral infectionNA219554432011NA
PRRID_0939Paclitaxel

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Pacific yew (plant)C1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)CNAPattern-associated molecular patterns (PAMPs)Syntheticused to treat a number of types of cancerNucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)HumanMyeloid cells, microglia, astrocytes, neuronsNAQ9HC29.fastaQ9HC291040TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA219825582011Pubchem Assay
PRRID_0939Paclitaxel

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Pacific yew (plant)C1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)CNAPattern-associated molecular patterns (PAMPs)Syntheticused to treat a number of types of cancerNucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)HumanMyeloid cells, microglia, astrocytes, neuronsNAQ9HC29.fastaQ9HC291040TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA219825582011Pubchem Assay
PRRID_0954Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAsignificant role in the pathogenesis of severe inflammatory responses NA219554432011NA
PRRID_0954Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAsignificant role in the pathogenesis of severe inflammatory responses NA219554432011NA
PRRID_0957Resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticimmune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)NANANANANANAimportant role in the immune response to viral infectionNA219498662011NA
PRRID_0957Resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticimmune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)NANANANANANAimportant role in the immune response to viral infectionNA219498662011NA
PRRID_0963Soluble factors

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Neisseria meningitidis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 1 (TLR1)Toll-like receptor (TLR)NANANANANANANANA219554432011NA
PRRID_0963Soluble factors

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Neisseria meningitidis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 1 (TLR1)Toll-like receptor (TLR)NANANANANANANANA219554432011NA
PRRID_0965Taxol

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PlantCC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)CNAPattern-associated molecular patterns (PAMPs)Syntheticused to treat a number of types of cancerToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA219554432011NA
PRRID_0965Taxol

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PlantCC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)CNAPattern-associated molecular patterns (PAMPs)Syntheticused to treat a number of types of cancerToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA219554432011NA
PRRID_0971Uropathogenic E. coli

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BacteriaNANAPattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 10 (TLR10)Toll-like receptor (TLR)HumanMyeloid cells, uroepithelial cellsNANANANATLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion.NA219825582011NA
PRRID_0971Uropathogenic E. coli

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BacteriaNANAPattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 10 (TLR10)Toll-like receptor (TLR)HumanMyeloid cells, uroepithelial cellsNANANANATLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion.NA219825582011NA
PRRID_1026Bropirimine

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NAC1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)BrNAPattern-associated molecular patterns (PAMPs)Syntheticexperimental drug with anti-cancer and antiviral propertiesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Micemonocyte/macrophages, plasmacytoid DCs and B-lymphocytesCell Compartment/Intracellular (Endosome)P58681.fastaP586811050important role in the immune response to viral infectionNA239853022013Pubchem Assay
PRRID_1026Bropirimine

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NAC1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)BrNAPattern-associated molecular patterns (PAMPs)Syntheticexperimental drug with anti-cancer and antiviral propertiesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Micemonocyte/macrophages, plasmacytoid DCs and B-lymphocytesCell Compartment/Intracellular (Endosome)P58681.fastaP586811050important role in the immune response to viral infectionNA239853022013Pubchem Assay
PRRID_1028Bropirimine

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NAC1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)BrNAPattern-associated molecular patterns (PAMPs)Syntheticexperimental drug with anti-cancer and antiviral propertiesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humanmonocyte/macrophages, plasmacytoid DCs and B-lymphocytesCell Compartment/Intracellular (Endosome)Q9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA239853022013Pubchem Assay
PRRID_1028Bropirimine

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NAC1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)BrNAPattern-associated molecular patterns (PAMPs)Syntheticexperimental drug with anti-cancer and antiviral propertiesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humanmonocyte/macrophages, plasmacytoid DCs and B-lymphocytesCell Compartment/Intracellular (Endosome)Q9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA239853022013Pubchem Assay
PRRID_1036EfLTA

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Endogenous (others)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)Naturalplay an important role in inducing non-specific resistance against a broad range of viral infections.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs NANANAsignificant role in the pathogenesis of severe inflammatory responses NA239853022013NA
PRRID_1036EfLTA

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Endogenous (others)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)Naturalplay an important role in inducing non-specific resistance against a broad range of viral infections.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs NANANAsignificant role in the pathogenesis of severe inflammatory responses NA239853022013NA
PRRID_1037EfLTA

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Enterococcus faecalis (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalLTA contributes to the inflammatory responses and to the production of chemokines through TLR2 signaling Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)C57BL/6 miceMacrophagesNAQ9QUN7.fastaQ9QUN7784triggers the MyD88-dependent signaling pathway, leading to NF-kB activationELISA, RT-PCR, Flow cytometric analysis239641172013Pubchem_assay
PRRID_1037EfLTA

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Enterococcus faecalis (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalLTA contributes to the inflammatory responses and to the production of chemokines through TLR2 signaling Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)C57BL/6 miceMacrophagesNAQ9QUN7.fastaQ9QUN7784triggers the MyD88-dependent signaling pathway, leading to NF-kB activationELISA, RT-PCR, Flow cytometric analysis239641172013Pubchem_assay
PRRID_1065HKLM

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heat-killed Listeria monocytogenes (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NF-240985082013Pubchem_assay
PRRID_1065HKLM

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heat-killed Listeria monocytogenes (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NF-240985082013Pubchem_assay
PRRID_1066HKVP

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heat-killed Vibrio Parahaemolyticus (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784NANF-240985082013Pubchem_assay
PRRID_1066HKVP

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heat-killed Vibrio Parahaemolyticus (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784NANF-240985082013Pubchem_assay
PRRID_1085Imiquimod

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imidazoquinoline amine analogue to guanosine (others)CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)NaturalAmine analog to guanosine, is an immune response modifier with potent indirect antiviral activity.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanHEK293 cellsNAQ9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNF-240985082013Pubchem_assay
PRRID_1085Imiquimod

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imidazoquinoline amine analogue to guanosine (others)CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)NaturalAmine analog to guanosine, is an immune response modifier with potent indirect antiviral activity.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanHEK293 cellsNAQ9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNF-240985082013Pubchem_assay
PRRID_1105Macrophage activating lipoprotein-2 (MALP-2)

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Mycoplasma fermentans (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalIt primes macrophages for cytokines secretion Toll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1105Macrophage activating lipoprotein-2 (MALP-2)

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Mycoplasma fermentans (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalIt primes macrophages for cytokines secretion Toll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1107Macrophage activating lipoprotein-2 (MALP-2)

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Mycoplasma fermentans (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalIt primes macrophages for cytokines secretion Toll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1107Macrophage activating lipoprotein-2 (MALP-2)

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Mycoplasma fermentans (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalIt primes macrophages for cytokines secretion Toll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1112ODN2006

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oligonucleotides containing unmethylated CpG dinucleotides (others)5’-tcgtcgttttgtcgttttgtcgtt-3’24Pattern-associated molecular patterns (PAMPs)Syntheticinduce strong immunostimulatory effects trough activation of TLR9 in mammalian cells and type B CpG ODN2006 significantly induced IL-1b and IFN-a1Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanHEK293 cellsNAQ9NR96.fastaQ9NR961032TLR9 plays a crucial role in breaking tolerance and developing autoimmunity NF-240985082013Pubchem_assay
PRRID_1112ODN2006

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oligonucleotides containing unmethylated CpG dinucleotides (others)5’-tcgtcgttttgtcgttttgtcgtt-3’24Pattern-associated molecular patterns (PAMPs)Syntheticinduce strong immunostimulatory effects trough activation of TLR9 in mammalian cells and type B CpG ODN2006 significantly induced IL-1b and IFN-a1Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanHEK293 cellsNAQ9NR96.fastaQ9NR961032TLR9 plays a crucial role in breaking tolerance and developing autoimmunity NF-240985082013Pubchem_assay
PRRID_1126Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Micemonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs NANANAsignificant role in the pathogenesis of severe inflammatory responses NA239853022013NA
PRRID_1126Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Micemonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs NANANAsignificant role in the pathogenesis of severe inflammatory responses NA239853022013NA
PRRID_1128Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)Q9QUN7.fastaQ9QUN7784fundamental role in pathogen recognition and activation of innate immunity.NA239853022013Pubchem_assay
PRRID_1128Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)Q9QUN7.fastaQ9QUN7784fundamental role in pathogen recognition and activation of innate immunity.NA239853022013Pubchem_assay
PRRID_1131R-848

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticsufficient to permit access of activated T-cells to peripheral tissues and induce GVHDToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Micegraft-versus-host disease (GVHD)NAP58681.fastaP586811050important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1131R-848

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticsufficient to permit access of activated T-cells to peripheral tissues and induce GVHDToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Micegraft-versus-host disease (GVHD)NAP58681.fastaP586811050important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1132Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)O60603.fastaO60603784fundamental role in pathogen recognition and activation of innate immunity.NA239853022013Pubchem_assay
PRRID_1132Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)O60603.fastaO60603784fundamental role in pathogen recognition and activation of innate immunity.NA239853022013Pubchem_assay
PRRID_1133Resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticimmune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Micemonocyte/macrophages, plasmacytoid DCs and B-lymphocytesCell Compartment/Intracellular (Endosome)P58681.fastaP586811050important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1133Resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticimmune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Micemonocyte/macrophages, plasmacytoid DCs and B-lymphocytesCell Compartment/Intracellular (Endosome)P58681.fastaP586811050important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1134Resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticimmune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humanmonocyte/macrophages, plasmacytoid DCs and B-lymphocytesCell Compartment/Intracellular (Endosome)Q9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1134Resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticimmune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humanmonocyte/macrophages, plasmacytoid DCs and B-lymphocytesCell Compartment/Intracellular (Endosome)Q9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1135Resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticimmune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Micemonocyte/macrophages, DCs, mast cellsCell Compartment/Intracellular (Endosome)P58681.fastaP586811050important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1135Resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticimmune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Micemonocyte/macrophages, DCs, mast cellsCell Compartment/Intracellular (Endosome)P58681.fastaP586811050important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1140Resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticimmune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, mast cellsCell Compartment/Intracellular (Endosome)Q9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1140Resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticimmune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, mast cellsCell Compartment/Intracellular (Endosome)Q9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1148R-848

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticsufficient to permit access of activated T-cells to peripheral tissues and induce GVHDToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humangraft-versus-host disease (GVHD)NAQ9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1148R-848

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticsufficient to permit access of activated T-cells to peripheral tissues and induce GVHDToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humangraft-versus-host disease (GVHD)NAQ9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1154Snapin A

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Endogenous (others)MAGAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGIYPPGSPGK136Pattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs Q9QUN7.fastaQ9QUN7784significant role in the pathogenesis of severe inflammatory responses NA239853022013Pubchem_assay
PRRID_1154Snapin A

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Endogenous (others)MAGAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGIYPPGSPGK136Pattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs Q9QUN7.fastaQ9QUN7784significant role in the pathogenesis of severe inflammatory responses NA239853022013Pubchem_assay