Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_2087	Glycerol monomycolate (MMG, GroMM) Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Mincle(Clec4e)	Syk-coupled CLR	Human	NA	NA	Q9ULY5.fasta	Q9ULY5	219	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2087	Glycerol monomycolate (MMG, GroMM) Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Mincle(Clec4e)	Syk-coupled CLR	Human	NA	NA	Q9ULY5.fasta	Q9ULY5	219	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2089	Glycolipids Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	elicit innate immune response	Mincle	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2089	Glycolipids Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	elicit innate immune response	Mincle	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2094	GW4064 Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	GW4064 attenuated LPS-induced ileum injury and mitochondria dysfunction by sup- pressed TLR4/MyD88 signaling-mediated inflammation and apoptosis.	Farnesoid X receptor (FXR)	Pattern recognition receptor (PRR)	Mice	Macrophages	NA	Q60641.fasta	Q60641	488	role in enteroprotection and mucosal injury by regulating inflammatory responses and barrier function in the intestinal tract.	RT-qPCR	28647362	2017	Pubchem_assay
PRRID_2094	GW4064 Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	GW4064 attenuated LPS-induced ileum injury and mitochondria dysfunction by sup- pressed TLR4/MyD88 signaling-mediated inflammation and apoptosis.	Farnesoid X receptor (FXR)	Pattern recognition receptor (PRR)	Mice	Macrophages	NA	Q60641.fasta	Q60641	488	role in enteroprotection and mucosal injury by regulating inflammatory responses and barrier function in the intestinal tract.	RT-qPCR	28647362	2017	Pubchem_assay
PRRID_2095	H. pylori-derived components Click for more detail	H. pylori (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	gastrointestinal epithelial cells	LRR and TIR domain	O60603.fasta	O60603	784	transcription factor NF-Œ∫B is activated and leads to the quick expression of proinflammatory cytokines, chemokines and inducible nitric oxide synthase (iNOS)	qRT-PCR	28427896	2017	Pubchem_assay
PRRID_2095	H. pylori-derived components Click for more detail	H. pylori (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	gastrointestinal epithelial cells	LRR and TIR domain	O60603.fasta	O60603	784	transcription factor NF-Œ∫B is activated and leads to the quick expression of proinflammatory cytokines, chemokines and inducible nitric oxide synthase (iNOS)	qRT-PCR	28427896	2017	Pubchem_assay
PRRID_2096	H. pylori-derived components Click for more detail	H. pylori (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	gastrointestinal epithelial cells	LRR and TIR domain	O00206.fasta	O00206	839	transcription factor NF-Œ∫B is activated and leads to the quick expression of proinflammatory cytokines, chemokines and inducible nitric oxide synthase (iNOS)	qRT-PCR	28427896	2017	Pubchem_assay
PRRID_2096	H. pylori-derived components Click for more detail	H. pylori (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	gastrointestinal epithelial cells	LRR and TIR domain	O00206.fasta	O00206	839	transcription factor NF-Œ∫B is activated and leads to the quick expression of proinflammatory cytokines, chemokines and inducible nitric oxide synthase (iNOS)	qRT-PCR	28427896	2017	Pubchem_assay
PRRID_2152	Hemozoin Click for more detail	Plasmodium falciparum (others)	CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5]	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Plasmodium falciparum-infected erythro- cytes, that co-purifies with the parasite product hemozoin, stimulates NOD2 in a RIP2/CARD9- dependent manner to drive nitric oxide production by macrophages	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	Macrophages	nucleotide-binding oligomerization domain	Q8K3Z0.fasta	Q8K3Z0	1020	Hemozoin-mediated induction of NOS	NA	28823510	2017	Pubchem_assay
PRRID_2152	Hemozoin Click for more detail	Plasmodium falciparum (others)	CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5]	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Plasmodium falciparum-infected erythro- cytes, that co-purifies with the parasite product hemozoin, stimulates NOD2 in a RIP2/CARD9- dependent manner to drive nitric oxide production by macrophages	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	Macrophages	nucleotide-binding oligomerization domain	Q8K3Z0.fasta	Q8K3Z0	1020	Hemozoin-mediated induction of NOS	NA	28823510	2017	Pubchem_assay
PRRID_2157	hexavalent lactoside Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Dectin-1 (Clec7a)	Syk-coupled CLR	Infection model	NA	NA	NA	NA	NA	Protective role in infection model	NA	28167651	2017	NA
PRRID_2157	hexavalent lactoside Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Dectin-1 (Clec7a)	Syk-coupled CLR	Infection model	NA	NA	NA	NA	NA	Protective role in infection model	NA	28167651	2017	NA
PRRID_2209	Imidazoquinoline Click for more detail	NA	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Synthesis of IFNŒ±, inflammatory cytokine production by macrophages, proliferation of splenocytes or maturation of DCs , Produce type I IFNs and other cytokines, maturation of pDCs, stimulate T-cells ,Reduces plasma virus concentration in chronic hepatitis C infection	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	NA	NA	29028369	2017	Pubchem_assay
PRRID_2209	Imidazoquinoline Click for more detail	NA	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Synthesis of IFNŒ±, inflammatory cytokine production by macrophages, proliferation of splenocytes or maturation of DCs , Produce type I IFNs and other cytokines, maturation of pDCs, stimulate T-cells ,Reduces plasma virus concentration in chronic hepatitis C infection	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	NA	NA	29028369	2017	Pubchem_assay
PRRID_2215	Ju-6 Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Dectin-1 (Clec7a)	Syk-coupled CLR	Infection model	NA	NA	NA	NA	NA	Protective role in infection model	NA	28167651	2017	NA
PRRID_2215	Ju-6 Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Dectin-1 (Clec7a)	Syk-coupled CLR	Infection model	NA	NA	NA	NA	NA	Protective role in infection model	NA	28167651	2017	NA
PRRID_2220	Laminarin Click for more detail	NA	C(C1C(C(C(C(O1)O)O)OC2C(C(C(C(O2)CO)O)OC3C(C(C(C(O3)CO)O)O)O)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Dectin-1 (Clec7a)	Syk-coupled CLR	Infection model	NA	NA	NA	NA	NA	Protective role in infection model	NA	28167651	2017	NA
PRRID_2220	Laminarin Click for more detail	NA	C(C1C(C(C(C(O1)O)O)OC2C(C(C(C(O2)CO)O)OC3C(C(C(C(O3)CO)O)O)O)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Dectin-1 (Clec7a)	Syk-coupled CLR	Infection model	NA	NA	NA	NA	NA	Protective role in infection model	NA	28167651	2017	NA
PRRID_2221	Ligand on parenchymal/ inflammatory cells in liver Click for more detail	Endogenous (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Dectin-1 (Clec7a)	Syk-coupled CLR	Infection model	NA	NA	NA	NA	NA	Protective role in infection model	NA	28167651	2017	NA
PRRID_2221	Ligand on parenchymal/ inflammatory cells in liver Click for more detail	Endogenous (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Dectin-1 (Clec7a)	Syk-coupled CLR	Infection model	NA	NA	NA	NA	NA	Protective role in infection model	NA	28167651	2017	NA
PRRID_2226	lipomannas Click for more detail	Mycobacteria (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	causes tuberculosis-like systemic infection in sh and in other ectotherms	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	THP‚Äê1 macrophages	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA	29183333	2017	Pubchem_assay
PRRID_2226	lipomannas Click for more detail	Mycobacteria (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	causes tuberculosis-like systemic infection in sh and in other ectotherms	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	THP‚Äê1 macrophages	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA	29183333	2017	Pubchem_assay
PRRID_2227	lipomannas Click for more detail	Mycobacteria (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	causes tuberculosis-like systemic infection in sh and in other ectotherms	CR3	Complement Receptor	Human	THP‚Äê1 macrophages	NA	NA	NA	NA	NA	THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA	29183333	2017	NA
PRRID_2227	lipomannas Click for more detail	Mycobacteria (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	causes tuberculosis-like systemic infection in sh and in other ectotherms	CR3	Complement Receptor	Human	THP‚Äê1 macrophages	NA	NA	NA	NA	NA	THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA	29183333	2017	NA
PRRID_2288	Lipoprotein Click for more detail	S. gordonii (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	apical periodontitis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	PDL cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	induces IL-8 production through activation of TLR2 in human PDL cells.	ELISA	28963931	2017	Pubchem_assay
PRRID_2288	Lipoprotein Click for more detail	S. gordonii (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	apical periodontitis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	PDL cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	induces IL-8 production through activation of TLR2 in human PDL cells.	ELISA	28963931	2017	Pubchem_assay
PRRID_2289	Lipoprotein Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	mononuclear phagocytes	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	mRNA ‚Üë in aging	NA	28801521	2017	Pubchem_assay
PRRID_2289	Lipoprotein Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	mononuclear phagocytes	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	mRNA ‚Üë in aging	NA	28801521	2017	Pubchem_assay
PRRID_2290	Lipoprotein Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Brain	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	mRNA ‚Üë in plaque- associated brain tissue of AD model mice	NA	28801521	2017	Pubchem_assay
PRRID_2290	Lipoprotein Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Brain	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	mRNA ‚Üë in plaque- associated brain tissue of AD model mice	NA	28801521	2017	Pubchem_assay
PRRID_2291	Lipoprotein Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	(hippocampus, entorhinal cortex, superior frontal gyrus, post-central gyrus)	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	mRNA ‚Üë in aging and AD	NA	28801521	2017	Pubchem_assay
PRRID_2291	Lipoprotein Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	(hippocampus, entorhinal cortex, superior frontal gyrus, post-central gyrus)	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	mRNA ‚Üë in aging and AD	NA	28801521	2017	Pubchem_assay
PRRID_2292	Lipoprotein Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Rat	hippocampus (microglia)	Leucine-rich Repeat (LRR) Domain	Q6YGU2.fasta	Q6YGU2	784	mRNA ‚Üë in postoperative cognitive dysfunction in senile animals	NA	28801521	2017	Pubchem_assay
PRRID_2292	Lipoprotein Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Rat	hippocampus (microglia)	Leucine-rich Repeat (LRR) Domain	Q6YGU2.fasta	Q6YGU2	784	mRNA ‚Üë in postoperative cognitive dysfunction in senile animals	NA	28801521	2017	Pubchem_assay
PRRID_2293	Lipoprotein Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Microglia	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	involved in both amyloid-Œ≤ uptake and inflammatory cytokine production	NA	28801521	2017	Pubchem_assay
PRRID_2293	Lipoprotein Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Microglia	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	involved in both amyloid-Œ≤ uptake and inflammatory cytokine production	NA	28801521	2017	Pubchem_assay
PRRID_2294	Lipoprotein Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Brain(neurons)	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	protein ‚Üë in PD	NA	28801521	2017	Pubchem_assay
PRRID_2294	Lipoprotein Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Brain(neurons)	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	protein ‚Üë in PD	NA	28801521	2017	Pubchem_assay
PRRID_2295	Lipoprotein Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Rat	brain (vasculature)	Leucine-rich Repeat (LRR) Domain	Q6YGU2.fasta	Q6YGU2	784	protein ‚Üë, activation in ischemic stroke	NA	28801521	2017	Pubchem_assay
PRRID_2295	Lipoprotein Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Rat	brain (vasculature)	Leucine-rich Repeat (LRR) Domain	Q6YGU2.fasta	Q6YGU2	784	protein ‚Üë, activation in ischemic stroke	NA	28801521	2017	Pubchem_assay
PRRID_2296	Lipoprotein Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Neurons(cortex)	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	protein ‚Üë, proapoptotic in ischemia	NA	28801521	2017	Pubchem_assay
PRRID_2296	Lipoprotein Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Neurons(cortex)	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	protein ‚Üë, proapoptotic in ischemia	NA	28801521	2017	Pubchem_assay
PRRID_2309	Long ds RNA Click for more detail	EMCV, poliovirus and coxasackie virus; Rotavirus, dengue virus, WNV, murine hepatitis virus(virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	filament formation mediated receptor tetramerization	MDA5	Rig-like receptor (RLR)	Human	Cytoplasm, all mammalian cell types	NA	Q53TB6.fasta	Q53TB6	435	MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2309	Long ds RNA Click for more detail	EMCV, poliovirus and coxasackie virus; Rotavirus, dengue virus, WNV, murine hepatitis virus(virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	filament formation mediated receptor tetramerization	MDA5	Rig-like receptor (RLR)	Human	Cytoplasm, all mammalian cell types	NA	Q53TB6.fasta	Q53TB6	435	MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2311	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosomes. pDCs and B cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2311	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosomes. pDCs and B cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2322	Malassezia furfur, glycolipid Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Mincle(Clec4e)	Syk-coupled CLR	Mice	NA	NA	Q9R0Q8.fasta	Q9R0Q8	214	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2322	Malassezia furfur, glycolipid Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Mincle(Clec4e)	Syk-coupled CLR	Mice	NA	NA	Q9R0Q8.fasta	Q9R0Q8	214	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2329	Mannose and fucose Click for more detail	L. monocytogenes (Bacteria)	C(C1C(C(C(C(O1)O)O)O)O)O and CC(C(C(C(C=O)O)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Activation of CLEC5A	CLEC5A	C type Lectin (CTL/CLR)	Human	monocytes, macrophages and neutrophils.	NA	Q14DL9.fasta	Q14DL9	165	secretion of proinflammatory cytokines such as TNF, IL-6, CXCL-8, and IP-10.	Binding assay	28824166	2017	Pubchem_assay
PRRID_2329	Mannose and fucose Click for more detail	L. monocytogenes (Bacteria)	C(C1C(C(C(C(O1)O)O)O)O)O and CC(C(C(C(C=O)O)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Activation of CLEC5A	CLEC5A	C type Lectin (CTL/CLR)	Human	monocytes, macrophages and neutrophils.	NA	Q14DL9.fasta	Q14DL9	165	secretion of proinflammatory cytokines such as TNF, IL-6, CXCL-8, and IP-10.	Binding assay	28824166	2017	Pubchem_assay
PRRID_2330	Maturing conidia Click for more detail	Aspergillus fumigatus(fungi)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Dectin-1 (Clec7a)	Syk-coupled CLR	Mice	NA	NA	Q6QLQ4.fasta	Q6QLQ4	244	protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2330	Maturing conidia Click for more detail	Aspergillus fumigatus(fungi)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Dectin-1 (Clec7a)	Syk-coupled CLR	Mice	NA	NA	Q6QLQ4.fasta	Q6QLQ4	244	protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2331	Maturing conidia Click for more detail	Aspergillus fumigatus(fungi)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Dectin-1 (Clec7a)	Syk-coupled CLR	Human	NA	NA	Q9BXN2.fasta	Q9BXN2	247	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2331	Maturing conidia Click for more detail	Aspergillus fumigatus(fungi)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Dectin-1 (Clec7a)	Syk-coupled CLR	Human	NA	NA	Q9BXN2.fasta	Q9BXN2	247	Protective role in infection model	NA	28167651	2017	Pubchem_assay
PRRID_2343	Microbial DNA Click for more detail	E. coli(Bacteria)	MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK	396	Pattern-associated molecular patterns (PAMPs)	Natural	Bacterial infection	DC-SIGN	C type Lectin (CTL/CLR)	Human	monocytes	NA	NA	NA	NA	NA	NA	28976999	2017	NA
PRRID_2343	Microbial DNA Click for more detail	E. coli(Bacteria)	MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK	396	Pattern-associated molecular patterns (PAMPs)	Natural	Bacterial infection	DC-SIGN	C type Lectin (CTL/CLR)	Human	monocytes	NA	NA	NA	NA	NA	NA	28976999	2017	NA
PRRID_2344	Microfilarial protein (MfP) Click for more detail	W. bancrofti (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	binds to macrophage-TLR4 and triggers NF-Œ∫B activation that up-regulates secretion of proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	Leucine-rich Repeat (LRR) Domain	O00206.fasta	O00206	839	NF-Œ∫B activation that up-regulates secretion of proinflammatory cytokines.	co-immunoprecipitation, FITC-probing and Surface Plasmon Resonance analysis.	28453850	2017	Pubchem_assay
PRRID_2344	Microfilarial protein (MfP) Click for more detail	W. bancrofti (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	binds to macrophage-TLR4 and triggers NF-Œ∫B activation that up-regulates secretion of proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	Leucine-rich Repeat (LRR) Domain	O00206.fasta	O00206	839	NF-Œ∫B activation that up-regulates secretion of proinflammatory cytokines.	co-immunoprecipitation, FITC-probing and Surface Plasmon Resonance analysis.	28453850	2017	Pubchem_assay
PRRID_2357	Mycotoxin Click for more detail	Fungi	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Binding and activation btTOLL	BtToll	Toll-like receptor (TLR)	NA	3rd nymphal instar.	TIR domain	NA	NA	NA	microbe detection, AMPs production, phagosome regulations, inflammatory signaling and activation	qRT-PCR	28648996	2017	NA
PRRID_2357	Mycotoxin Click for more detail	Fungi	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Binding and activation btTOLL	BtToll	Toll-like receptor (TLR)	NA	3rd nymphal instar.	TIR domain	NA	NA	NA	microbe detection, AMPs production, phagosome regulations, inflammatory signaling and activation	qRT-PCR	28648996	2017	NA
PRRID_2436	NA Click for more detail	Enterovirus 71 (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29052054	2017	Pubchem_assay
PRRID_2436	NA Click for more detail	Enterovirus 71 (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29052054	2017	Pubchem_assay
PRRID_2437	NA Click for more detail	CA16(others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29052054	2017	Pubchem_assay
PRRID_2437	NA Click for more detail	CA16(others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29052054	2017	Pubchem_assay
PRRID_2438	NA Click for more detail	S. cerevisiae (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	elicit innate immune response	CREP4	C type Lectin (CTL/CLR)	B. glabRata	NA	NA	NA	NA	NA	NA	transcriptomic data	29051762	2017	NA
PRRID_2438	NA Click for more detail	S. cerevisiae (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	elicit innate immune response	CREP4	C type Lectin (CTL/CLR)	B. glabRata	NA	NA	NA	NA	NA	NA	transcriptomic data	29051762	2017	NA
PRRID_2439	NA Click for more detail	E. coli(Bacteria)	MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK	396	Pattern-associated molecular patterns (PAMPs)	Natural	NA	hyal-adherins (H-type)	Lectins	NA	NA	NA	NA	NA	NA	induces pro-inflammatory cytokine response	NA	29051762	2017	NA
PRRID_2439	NA Click for more detail	E. coli(Bacteria)	MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK	396	Pattern-associated molecular patterns (PAMPs)	Natural	NA	hyal-adherins (H-type)	Lectins	NA	NA	NA	NA	NA	NA	induces pro-inflammatory cytokine response	NA	29051762	2017	NA
PRRID_2440	NA Click for more detail	metazoan parasites (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	FREPs	Lectins	snails	NA	NA	NA	NA	NA	induces pro-inflammatory cytokine response	NA	29051762	2017	NA
PRRID_2440	NA Click for more detail	metazoan parasites (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	FREPs	Lectins	snails	NA	NA	NA	NA	NA	induces pro-inflammatory cytokine response	NA	29051762	2017	NA
PRRID_2441	NA Click for more detail	S. mansoni (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	biomphalysin	aerolysin-like protein	NA	NA	one large domain that shares structure similarities with Œ≤-pore-forming and a small domain potentially involved in pathogens‚Äô carbohydrate motifs recognition	NA	NA	NA	NA	NA	29051762	2017	NA
PRRID_2441	NA Click for more detail	S. mansoni (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	biomphalysin	aerolysin-like protein	NA	NA	one large domain that shares structure similarities with Œ≤-pore-forming and a small domain potentially involved in pathogens‚Äô carbohydrate motifs recognition	NA	NA	NA	NA	NA	29051762	2017	NA
PRRID_2442	NA Click for more detail	E. coli(Bacteria)	MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK	396	Pattern-associated molecular patterns (PAMPs)	Natural	elicit innate immune response	CTL4	C type Lectin (CTL/CLR)	Anopheles gambiae	NA	NA	B2FX81.fasta	B2FX81	150	NA	NA	29051762	2017	Pubchem_assay
PRRID_2442	NA Click for more detail	E. coli(Bacteria)	MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK	396	Pattern-associated molecular patterns (PAMPs)	Natural	elicit innate immune response	CTL4	C type Lectin (CTL/CLR)	Anopheles gambiae	NA	NA	B2FX81.fasta	B2FX81	150	NA	NA	29051762	2017	Pubchem_assay
PRRID_2448	NA Click for more detail	Staphyloccocus aureus or Vibrio parahaemolyticus (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Innate immunity elicitor	EsSR-B1	Scavenger receptor (SR)	Eriocheir sinensis	all tissue specially hemocytes	Class B SRs are type III transmembrane receptors with two transmembrane domains,	NA	NA	NA	phagocytosis of invading bacteria	qRT-PCR	28916359	2017	NA
PRRID_2448	NA Click for more detail	Staphyloccocus aureus or Vibrio parahaemolyticus (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Innate immunity elicitor	EsSR-B1	Scavenger receptor (SR)	Eriocheir sinensis	all tissue specially hemocytes	Class B SRs are type III transmembrane receptors with two transmembrane domains,	NA	NA	NA	phagocytosis of invading bacteria	qRT-PCR	28916359	2017	NA
PRRID_2449	NA Click for more detail	Vibrio anguillarum (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	innate immunity elicitor	CgLRRIG-1	Pattern recognition receptor (PRR)	oyster Crassostrea gigas	Muscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas.	Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domain	NA	NA	NA	immune effectors or pro-inflammatory factors as well as PRRs in oyster.	PAMPs binding assay	28889011	2017	NA
PRRID_2449	NA Click for more detail	Vibrio anguillarum (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	innate immunity elicitor	CgLRRIG-1	Pattern recognition receptor (PRR)	oyster Crassostrea gigas	Muscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas.	Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domain	NA	NA	NA	immune effectors or pro-inflammatory factors as well as PRRs in oyster.	PAMPs binding assay	28889011	2017	NA
PRRID_2450	NA Click for more detail	Vibrio anguillarum (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	innate immunity elicitor	CgLRRIG-2	Pattern recognition receptor (PRR)	oyster Crassostrea gigas	Muscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas.	Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domain	NA	NA	NA	immune effectors or pro-inflammatory factors as well as PRRs in oyster.	PAMPs binding assay	28889011	2017	NA
PRRID_2450	NA Click for more detail	Vibrio anguillarum (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	innate immunity elicitor	CgLRRIG-2	Pattern recognition receptor (PRR)	oyster Crassostrea gigas	Muscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas.	Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domain	NA	NA	NA	immune effectors or pro-inflammatory factors as well as PRRs in oyster.	PAMPs binding assay	28889011	2017	NA
PRRID_2455	NA Click for more detail	Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Stimulation of CfLRRop-4	CfLRRop-4	Pattern recognition receptor (PRR)	Zhikong scallop Chlamys farreri	hepatopancreas, gills and gonads	six LRR motifs plus one LRR_TYP	NA	NA	NA	NA	NA	28807724	2017	NA
PRRID_2455	NA Click for more detail	Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Stimulation of CfLRRop-4	CfLRRop-4	Pattern recognition receptor (PRR)	Zhikong scallop Chlamys farreri	hepatopancreas, gills and gonads	six LRR motifs plus one LRR_TYP	NA	NA	NA	NA	NA	28807724	2017	NA
PRRID_2456	NA Click for more detail	Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Stimulation of CfLRRop-5	CfLRRop-5	Pattern recognition receptor (PRR)	Zhikong scallop Chlamys farreri	hepatopancreas, gills and gonads	one LRRNT motif plus five LRR motifs,	NA	NA	NA	NA	NA	28807724	2017	NA
PRRID_2456	NA Click for more detail	Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Stimulation of CfLRRop-5	CfLRRop-5	Pattern recognition receptor (PRR)	Zhikong scallop Chlamys farreri	hepatopancreas, gills and gonads	one LRRNT motif plus five LRR motifs,	NA	NA	NA	NA	NA	28807724	2017	NA
PRRID_2457	NA Click for more detail	Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Stimulation of CfLRRop-6	CfLRRop-6	Pattern recognition receptor (PRR)	Zhikong scallop Chlamys farreri	hepatopancreas, gills and gonads	merely three LRR motifs	NA	NA	NA	NA	NA	28807724	2017	NA
PRRID_2457	NA Click for more detail	Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Stimulation of CfLRRop-6	CfLRRop-6	Pattern recognition receptor (PRR)	Zhikong scallop Chlamys farreri	hepatopancreas, gills and gonads	merely three LRR motifs	NA	NA	NA	NA	NA	28807724	2017	NA
PRRID_2458	NA Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	substantia nigra	NA	Q8R4B8.fasta	Q8R4B8	1033	protein ‚Üë, activation of NLRP3 inflammasome in PD models	NA	28801521	2017	Pubchem_assay
PRRID_2458	NA Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	substantia nigra	NA	Q8R4B8.fasta	Q8R4B8	1033	protein ‚Üë, activation of NLRP3 inflammasome in PD models	NA	28801521	2017	Pubchem_assay
PRRID_2459	NA Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Binding and activation btTOLL	BtToll	Toll-like receptor (TLR)	Bemisia tabaci (Gennadius)	3rd nymphal instar.	TIR domain	NA	NA	NA	Microbe detection, AMPs production, phagosome regulations, inflammatory signaling and activation	qRT-PCR	28648996	2017	NA
PRRID_2459	NA Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Binding and activation btTOLL	BtToll	Toll-like receptor (TLR)	Bemisia tabaci (Gennadius)	3rd nymphal instar.	TIR domain	NA	NA	NA	Microbe detection, AMPs production, phagosome regulations, inflammatory signaling and activation	qRT-PCR	28648996	2017	NA
PRRID_2460	NA Click for more detail	A.hydrophilla(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Activation of CLR.	CaNTC	C type Lectin (CTL/CLR)	Carassius auratus	liver, spleen and head-kidney	Carbohydrate recognition domain (CRD)	NA	NA	NA	pathogen recognition in Qihe 538 crucian carp	Microbial binding assay	28602683	2017	NA
PRRID_2460	NA Click for more detail	A.hydrophilla(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Activation of CLR.	CaNTC	C type Lectin (CTL/CLR)	Carassius auratus	liver, spleen and head-kidney	Carbohydrate recognition domain (CRD)	NA	NA	NA	pathogen recognition in Qihe 538 crucian carp	Microbial binding assay	28602683	2017	NA
PRRID_2461	NA Click for more detail	A.hydrophilla(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Pf_Toll-like receptor (TLR18)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	spleen, head kidney, trunk kidney, liver and blood	Leucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA
PRRID_2461	NA Click for more detail	A.hydrophilla(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Pf_Toll-like receptor (TLR18)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	spleen, head kidney, trunk kidney, liver and blood	Leucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA
PRRID_2462	NA Click for more detail	A.hydrophilla(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Pf_Toll-like receptor 19 (TLR19)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	spleen, head kidney, trunk kidney, liver and blood	Leucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA
PRRID_2462	NA Click for more detail	A.hydrophilla(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Pf_Toll-like receptor 19 (TLR19)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	spleen, head kidney, trunk kidney, liver and blood	Leucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA
PRRID_2463	NA Click for more detail	A.hydrophilla(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Pf_Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	spleen, head kidney, trunk kidney, liver and blood	LRR and TIR domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA
PRRID_2463	NA Click for more detail	A.hydrophilla(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Pf_Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	spleen, head kidney, trunk kidney, liver and blood	LRR and TIR domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA

previous 1 2 3 4 567 8 9...15 16 next