| Primary information |
|---|
| PRRID | PRRID_2344 |
| Ligand Name | Microfilarial protein (MfP) |
| Source | W. bancrofti (others) |
| Sequence of ligand | NA |
| Length | NA |
| Type | Pattern-associated molecular patterns (PAMPs) |
| Occurence | Natural |
| Role of Ligand | binds to macrophage-TLR4 and triggers NF-κB activation that up-regulates secretion of proinflammatory cytokines. |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | Macrophages |
| Domain | Leucine-rich Repeat (LRR) Domain |
| Sequence of Receptor | O00206.fasta |
| Swiss prot ID | O00206 |
| Length Of Receptor | 839 |
| Function | NF-κB activation that up-regulates secretion of proinflammatory cytokines. |
| Assay used | co-immunoprecipitation, FITC-probing and Surface Plasmon Resonance analysis. |
| PMID | 28453850 |
| Year of Publication | 2017 |
| Pubchem assay | Pubchem_assay |
| Primary information |
|---|
| PRRID | PRRID_2344 |
| Ligand Name | Microfilarial protein (MfP) |
| Source | W. bancrofti (others) |
| Sequence of ligand | NA |
| Length | NA |
| Type | Pattern-associated molecular patterns (PAMPs) |
| Occurence | Natural |
| Role of Ligand | binds to macrophage-TLR4 and triggers NF-κB activation that up-regulates secretion of proinflammatory cytokines. |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | Macrophages |
| Domain | Leucine-rich Repeat (LRR) Domain |
| Sequence of Receptor | O00206.fasta |
| Swiss prot ID | O00206 |
| Length Of Receptor | 839 |
| Function | NF-κB activation that up-regulates secretion of proinflammatory cytokines. |
| Assay used | co-immunoprecipitation, FITC-probing and Surface Plasmon Resonance analysis. |
| PMID | 28453850 |
| Year of Publication | 2017 |
| Pubchem assay | Pubchem_assay |