Primary information |
---|
PRRID | PRRID_2344 |
Ligand Name | Microfilarial protein (MfP) |
Source | W. bancrofti (others) |
Sequence of ligand | NA |
Length | NA |
Type | Pattern-associated molecular patterns (PAMPs) |
Occurence | Natural |
Role of Ligand | binds to macrophage-TLR4 and triggers NF-κB activation that up-regulates secretion of proinflammatory cytokines. |
Name of receptor | Toll-like receptor 4 (TLR4) |
Type of receptor | Toll-like receptor (TLR) |
Source | Human |
Localization | Macrophages |
Domain | Leucine-rich Repeat (LRR) Domain |
Sequence of Receptor | O00206.fasta |
Swiss prot ID | O00206 |
Length Of Receptor | 839 |
Function | NF-κB activation that up-regulates secretion of proinflammatory cytokines. |
Assay used | co-immunoprecipitation, FITC-probing and Surface Plasmon Resonance analysis. |
PMID | 28453850 |
Year of Publication | 2017 |
Pubchem assay | Pubchem_assay |
Primary information |
---|
PRRID | PRRID_2344 |
Ligand Name | Microfilarial protein (MfP) |
Source | W. bancrofti (others) |
Sequence of ligand | NA |
Length | NA |
Type | Pattern-associated molecular patterns (PAMPs) |
Occurence | Natural |
Role of Ligand | binds to macrophage-TLR4 and triggers NF-κB activation that up-regulates secretion of proinflammatory cytokines. |
Name of receptor | Toll-like receptor 4 (TLR4) |
Type of receptor | Toll-like receptor (TLR) |
Source | Human |
Localization | Macrophages |
Domain | Leucine-rich Repeat (LRR) Domain |
Sequence of Receptor | O00206.fasta |
Swiss prot ID | O00206 |
Length Of Receptor | 839 |
Function | NF-κB activation that up-regulates secretion of proinflammatory cytokines. |
Assay used | co-immunoprecipitation, FITC-probing and Surface Plasmon Resonance analysis. |
PMID | 28453850 |
Year of Publication | 2017 |
Pubchem assay | Pubchem_assay |