Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_2584rb-dsRNA

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Rice- bran (plant)NANAPattern-associated molecular patterns (PAMPs)Naturalactivate caspase 1 via TRIF, resulting in the release of IL-1b and LDHMDA5Rig-like receptor (RLR)MiceNANAQ8R5F7.fastaQ8R5F71025Caspase 1 activation is specifically induced by TLR3 signaling through TRIF/RIPK/ FADD.RT-qPCR288480652017Pubchem_assay
PRRID_2584rb-dsRNA

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Rice- bran (plant)NANAPattern-associated molecular patterns (PAMPs)Naturalactivate caspase 1 via TRIF, resulting in the release of IL-1b and LDHMDA5Rig-like receptor (RLR)MiceNANAQ8R5F7.fastaQ8R5F71025Caspase 1 activation is specifically induced by TLR3 signaling through TRIF/RIPK/ FADD.RT-qPCR288480652017Pubchem_assay
PRRID_2587RcCDI1

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Rhynchosporium commune (fungi)NANAPattern-associated molecular patterns (PAMPs)Naturalactivates cell death through a pathway that is distinct from that triggered by the oomycete PAMP INF1.NANAsolanaceousNANANANANANANA283869882017NA
PRRID_2587RcCDI1

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Rhynchosporium commune (fungi)NANAPattern-associated molecular patterns (PAMPs)Naturalactivates cell death through a pathway that is distinct from that triggered by the oomycete PAMP INF1.NANAsolanaceousNANANANANANANA283869882017NA
PRRID_2588repeated mannose units

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NAC(C1C(C(C(C(O1)O)O)O)O)O and CC(C(C(C(C=O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseMannose Receptor 1Mannose receptor (MR)NANANANANANANANA288015212017NA
PRRID_2588repeated mannose units

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NAC(C1C(C(C(C(O1)O)O)O)O)O and CC(C(C(C(C=O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseMannose Receptor 1Mannose receptor (MR)NANANANANANANANA288015212017NA
PRRID_2613SAP130

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Endogenous (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRInfection modelNAVEGQ motifNANANAProtective role in infection modelNA281676512017NA
PRRID_2613SAP130

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Endogenous (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRInfection modelNAVEGQ motifNANANAProtective role in infection modelNA281676512017NA
PRRID_2614short dsRNA

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EBOV, MV, SeV, NDV, RSV, flu virus, hantavirus,VSV, RV, HCV, JEV, adenovirus, vaccinia virus, HSV,L.NANAPattern-associated molecular patterns (PAMPs)NaturalK63-polyubiquitination/ polyubiquitin chain binding mediated receptor tetramerizationRIG-1Rig-like receptor (RLR)HumanCytoplasm, all mammalian cell typesNAO95786.fastaO95786925MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2614short dsRNA

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EBOV, MV, SeV, NDV, RSV, flu virus, hantavirus,VSV, RV, HCV, JEV, adenovirus, vaccinia virus, HSV,L.NANAPattern-associated molecular patterns (PAMPs)NaturalK63-polyubiquitination/ polyubiquitin chain binding mediated receptor tetramerizationRIG-1Rig-like receptor (RLR)HumanCytoplasm, all mammalian cell typesNAO95786.fastaO95786925MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2616Sindbis virus (SINV) RNA

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VirusNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantTetrachlorodibenzo-p-dioxin (TCDD)- inducible poly(ADP ribose) polymerase (TIPARP)Pattern recognition receptor (PRR)MiceCytoplasmzinc finger domainQ8C1B2.fastaQ8C1B2657recruits an exosome to induce viral RNA degradation.RNA immunoprecipitation Assay282134972017Pubchem_assay
PRRID_2616Sindbis virus (SINV) RNA

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VirusNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantTetrachlorodibenzo-p-dioxin (TCDD)- inducible poly(ADP ribose) polymerase (TIPARP)Pattern recognition receptor (PRR)MiceCytoplasmzinc finger domainQ8C1B2.fastaQ8C1B2657recruits an exosome to induce viral RNA degradation.RNA immunoprecipitation Assay282134972017Pubchem_assay
PRRID_2631Soluble Beta glucan

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NAC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2631Soluble Beta glucan

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NAC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2637sulfoglycolipids

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Mycobacterium tuberculosis (Bacteria)CCCCCCCCCCCCCCCC(=O)OC(COC1C(C(C(C(O1)CS(=O)(=O)O)O)O)O)COC(=O)CCCCCCCC=CCC=CCC=CCCNAPattern-associated molecular patterns (PAMPs)NaturalTuberculosisToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784inhibit NF-κB activation and subsequent cytokine production or costimulatory molecule expression by acting as competitive antagonistsTLR2 Binding assay289739282017Pubchem_assay
PRRID_2637sulfoglycolipids

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Mycobacterium tuberculosis (Bacteria)CCCCCCCCCCCCCCCC(=O)OC(COC1C(C(C(C(O1)CS(=O)(=O)O)O)O)O)COC(=O)CCCCCCCC=CCC=CCC=CCCNAPattern-associated molecular patterns (PAMPs)NaturalTuberculosisToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784inhibit NF-κB activation and subsequent cytokine production or costimulatory molecule expression by acting as competitive antagonistsTLR2 Binding assay289739282017Pubchem_assay
PRRID_2638synthetic dsRNA

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MCMV, HSV-1, EMCV, WNV,and enteroviruses (virus)NANAPattern-associated molecular patterns (PAMPs)SyntheticdsRNA induced dimerizationToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomes. Innate immune cells except neutrophils and pDCsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904TRIF-TRAF3-TBK1/ IKKe-IRF3. TRIF-TRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2638synthetic dsRNA

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MCMV, HSV-1, EMCV, WNV,and enteroviruses (virus)NANAPattern-associated molecular patterns (PAMPs)SyntheticdsRNA induced dimerizationToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomes. Innate immune cells except neutrophils and pDCsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904TRIF-TRAF3-TBK1/ IKKe-IRF3. TRIF-TRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2640Synthetic trehalose diesters including TDB

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NANANAPattern-associated molecular patterns (PAMPs)SyntheticImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2640Synthetic trehalose diesters including TDB

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NANANAPattern-associated molecular patterns (PAMPs)SyntheticImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2641Synthetic trehalose diesters including corynomycolates

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NANANAPattern-associated molecular patterns (PAMPs)SyntheticImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2641Synthetic trehalose diesters including corynomycolates

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NANANAPattern-associated molecular patterns (PAMPs)SyntheticImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2642Synthetic trehalose monoesters

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NANANAPattern-associated molecular patterns (PAMPs)SyntheticImmunostimulantMincle(Clec4e)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2642Synthetic trehalose monoesters

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NANANAPattern-associated molecular patterns (PAMPs)SyntheticImmunostimulantMincle(Clec4e)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2643T cell ligand

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Endogenous (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2643T cell ligand

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Endogenous (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2644Taxol

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NACC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)CNAPattern-associated molecular patterns (PAMPs)NaturalEnhancement of dendritic cell maturation and alloreactive T-cell responses, Upregulate mRNA expressions of MCP-Ôõú, TNF- a, induction of proinflammatory cytokines, accelerate podocyte injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA290283692017Pubchem_assay
PRRID_2644Taxol

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NACC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)CNAPattern-associated molecular patterns (PAMPs)NaturalEnhancement of dendritic cell maturation and alloreactive T-cell responses, Upregulate mRNA expressions of MCP-Ôõú, TNF- a, induction of proinflammatory cytokines, accelerate podocyte injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA290283692017Pubchem_assay
PRRID_2645TDM

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRMiceNANAQ9Z2H6.fastaQ9Z2H6219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2645TDM

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRMiceNANAQ9Z2H6.fastaQ9Z2H6219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2646TDM

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRHumanNANAQ8WXI8.fastaQ8WXI8215Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2646TDM

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRHumanNANAQ8WXI8.fastaQ8WXI8215Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2647TDM

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2647TDM

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2648TDM

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2648TDM

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Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2668Unmethylated CpG DNA

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA288015212017NA
PRRID_2668Unmethylated CpG DNA

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA288015212017NA
PRRID_2688Viral effector epitope

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Tospovirus (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalBinding and activation of SW-5bSW-5bNOD-like receptor (NLR)Solanum LycopersicumNALRR domainNANANAConfers broad spectrum against American-type tospoviruses by recognizing a conserved 21-amino acid peptide region within viral movement protein NSm (NSm21)NA288146462017NA
PRRID_2688Viral effector epitope

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Tospovirus (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalBinding and activation of SW-5bSW-5bNOD-like receptor (NLR)Solanum LycopersicumNALRR domainNANANAConfers broad spectrum against American-type tospoviruses by recognizing a conserved 21-amino acid peptide region within viral movement protein NSm (NSm21)NA288146462017NA
PRRID_2693Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA292639322017Pubchem_assay
PRRID_2693Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904NANA292639322017Pubchem_assay
PRRID_2694Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA292639322017Pubchem_assay
PRRID_2694Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049NANA292639322017Pubchem_assay
PRRID_2695Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041NANA292639322017Pubchem_assay
PRRID_2695Viruses or bacteria

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Virus, BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalNAToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumancytoplasmLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041NANA292639322017Pubchem_assay
PRRID_2736β-galactosides

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NAC(C1C(C(C(C(O1)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalNAGal-1Pattern recognition receptor (PRR)NANANANANANANANA289862482018NA
PRRID_2736β-galactosides

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NAC(C1C(C(C(C(O1)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalNAGal-1Pattern recognition receptor (PRR)NANANANANANANANA289862482018NA
PRRID_2737β-galactosides

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Leishmania major (others)C(C1C(C(C(C(O1)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)Naturalcutaneous and visceral leishmaniasisGal-3Pattern recognition receptor (PRR)Micelymph nodes and higher parasite load in the footpadscarbohydrate recognition domainQ9JHE4 .fastaQ9JHE4423via modulation of the Notch signaling pathwayNA289862482018Pubchem_assay
PRRID_2737β-galactosides

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Leishmania major (others)C(C1C(C(C(C(O1)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)Naturalcutaneous and visceral leishmaniasisGal-3Pattern recognition receptor (PRR)Micelymph nodes and higher parasite load in the footpadscarbohydrate recognition domainQ9JHE4 .fastaQ9JHE4423via modulation of the Notch signaling pathwayNA289862482018Pubchem_assay
PRRID_2738β-galactosides

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P. marinus (others)C(C1C(C(C(C(O1)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)Naturalcauses “Dermo” disease in the eastern oyster Crassostrea virginicaC. virginica galectin (CvGal)Pattern recognition receptor (PRR)Crassostrea virginicahemocytesfour canonical galectin CRDs,NANANANANA289862482018NA
PRRID_2738β-galactosides

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P. marinus (others)C(C1C(C(C(C(O1)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)Naturalcauses “Dermo” disease in the eastern oyster Crassostrea virginicaC. virginica galectin (CvGal)Pattern recognition receptor (PRR)Crassostrea virginicahemocytesfour canonical galectin CRDs,NANANANANA289862482018NA