Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_2464NA

Click for more detail

S. iniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusLiver and spleenLeucine-rich Repeat (LRR) DomainNANANANF-κB-mediated in ammatory cytokine pro- duction.ELISA284955642017NA
PRRID_2464NA

Click for more detail

S. iniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusLiver and spleenLeucine-rich Repeat (LRR) DomainNANANANF-κB-mediated in ammatory cytokine pro- duction.ELISA284955642017NA
PRRID_2465NA

Click for more detail

E.Tarda(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusLiver and kidneyLeucine-rich Repeat (LRR) DomainNANANANAELISA284955642017NA
PRRID_2465NA

Click for more detail

E.Tarda(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusLiver and kidneyLeucine-rich Repeat (LRR) DomainNANANANAELISA284955642017NA
PRRID_2466NA

Click for more detail

HIRRV (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusGills and kidneyLeucine-rich Repeat (LRR) DomainNANANANAELISA284955642017NA
PRRID_2466NA

Click for more detail

HIRRV (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulanttbToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Scophthalmus maximusGills and kidneyLeucine-rich Repeat (LRR) DomainNANANANAELISA284955642017NA
PRRID_2467NA

Click for more detail

F. solani (fungi)NANAPattern-associated molecular patterns (PAMPs)Naturalupregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHuman corneal epithelial cells (HCECs)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784decreased AMP mRNA upregulationRT-PCR, antifungal assay284600482017Pubchem_assay
PRRID_2467NA

Click for more detail

F. solani (fungi)NANAPattern-associated molecular patterns (PAMPs)Naturalupregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHuman corneal epithelial cells (HCECs)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784decreased AMP mRNA upregulationRT-PCR, antifungal assay284600482017Pubchem_assay
PRRID_2468NA

Click for more detail

F. solani (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalUpregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism.Dectin-1C type Lectin (CTL/CLR)HumanHuman corneal epithelial cells (HCECs)NAQ9BXN2.fastaQ9BXN2247decreased AMP mRNA upregulationRT-PCR, antifungal assay284600482017Pubchem_assay
PRRID_2468NA

Click for more detail

F. solani (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalUpregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism.Dectin-1C type Lectin (CTL/CLR)HumanHuman corneal epithelial cells (HCECs)NAQ9BXN2.fastaQ9BXN2247decreased AMP mRNA upregulationRT-PCR, antifungal assay284600482017Pubchem_assay
PRRID_2469NA

Click for more detail

Grass carp reovirus (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantScToll-like receptor 2 (TLR2)2Toll-like receptor (TLR)Squaliobarbus curriculushead kidney and spleen19 leucine rich repeats (LRRs), a transmembrane (TM) and a Toll/interleukin-1 receptor (TIR) domain.NANANANF-κB activation that up-regulates secretion of proinflammatory cytokines.qRT-PCR284424182017NA
PRRID_2469NA

Click for more detail

Grass carp reovirus (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantScToll-like receptor 2 (TLR2)2Toll-like receptor (TLR)Squaliobarbus curriculushead kidney and spleen19 leucine rich repeats (LRRs), a transmembrane (TM) and a Toll/interleukin-1 receptor (TIR) domain.NANANANF-κB activation that up-regulates secretion of proinflammatory cytokines.qRT-PCR284424182017NA
PRRID_2470NA

Click for more detail

Gram-negative and Gram-positive bacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantrMjGCTLC type Lectin (CTL/CLR)Marsupenaeus japonicusHemocytesCRD with a QAP motif.NANANAacts as an opsonin by bind- ing directly to hemocytes to activate their adhesive state for their encapsulation.Bacterial agglutination assay283748482017NA
PRRID_2470NA

Click for more detail

Gram-negative and Gram-positive bacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantrMjGCTLC type Lectin (CTL/CLR)Marsupenaeus japonicusHemocytesCRD with a QAP motif.NANANAacts as an opsonin by bind- ing directly to hemocytes to activate their adhesive state for their encapsulation.Bacterial agglutination assay283748482017NA
PRRID_2471NA

Click for more detail

white spot syndrome virus (WSSV)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPcToll4Toll-like receptor (TLR)Procambarus clarkiiAll tested tissueA single peptide, 13 LRR domains, 3 LRR TYP domains, 2 LRR CT do- mains, an LRR NT domain, a transmembrane region, and a TIR domain.NANANAregulates the expressions of AMPs against WSSVqRT-PCR282130412017NA
PRRID_2471NA

Click for more detail

white spot syndrome virus (WSSV)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPcToll4Toll-like receptor (TLR)Procambarus clarkiiAll tested tissueA single peptide, 13 LRR domains, 3 LRR TYP domains, 2 LRR CT do- mains, an LRR NT domain, a transmembrane region, and a TIR domain.NANANAregulates the expressions of AMPs against WSSVqRT-PCR282130412017NA
PRRID_2472NA

Click for more detail

Klebsiella pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRNANANANANANAProtective role in infection modelNA281676512017NA
PRRID_2472NA

Click for more detail

Klebsiella pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRNANANANANANAProtective role in infection modelNA281676512017NA
PRRID_2473NA

Click for more detail

Mycobacterium tuberculosis, Mycobacterium bovis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRNANANANANANAProtective role in infection modelNA281676512017NA
PRRID_2473NA

Click for more detail

Mycobacterium tuberculosis, Mycobacterium bovis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRNANANANANANAProtective role in infection modelNA281676512017NA
PRRID_2474NA

Click for more detail

Blastomyces dermatitidis(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRMiceNANAQ9Z2H6.fastaQ9Z2H6219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2474NA

Click for more detail

Blastomyces dermatitidis(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRMiceNANAQ9Z2H6.fastaQ9Z2H6219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2475NA

Click for more detail

Candida albicans(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRInfection modelNANANANANAControversial role in infection modelsNA281676512017NA
PRRID_2475NA

Click for more detail

Candida albicans(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRInfection modelNANANANANAControversial role in infection modelsNA281676512017NA
PRRID_2476NA

Click for more detail

Cryptococcus neoformans(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRInfection modelNACRAC motifNANANAProtective role in infection disease.NA281676512017NA
PRRID_2476NA

Click for more detail

Cryptococcus neoformans(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMcl (Clec4d)Syk-coupled CLRInfection modelNACRAC motifNANANAProtective role in infection disease.NA281676512017NA
PRRID_2477NA

Click for more detail

H. pylori (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2477NA

Click for more detail

H. pylori (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2478NA

Click for more detail

Klebsiella pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2478NA

Click for more detail

Klebsiella pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2479NA

Click for more detail

S. pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2479NA

Click for more detail

S. pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2480NA

Click for more detail

M. tuberculosis, M. bovis, Mycobacterium smegmatis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2480NA

Click for more detail

M. tuberculosis, M. bovis, Mycobacterium smegmatis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2481NA

Click for more detail

M. tuberculosis, M. bovis, Mycobacterium smegmatis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2481NA

Click for more detail

M. tuberculosis, M. bovis, Mycobacterium smegmatis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2482NA

Click for more detail

Haemophilus influenzae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2482NA

Click for more detail

Haemophilus influenzae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2483NA

Click for more detail

Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2483NA

Click for more detail

Mycobacterium spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANAProtective role in infection modelNA281676512017NA
PRRID_2484NA

Click for more detail

Coccidioidis posadasii(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244protective role in infection modelNA281676512017Pubchem_assay
PRRID_2484NA

Click for more detail

Coccidioidis posadasii(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244protective role in infection modelNA281676512017Pubchem_assay
PRRID_2485NA

Click for more detail

Coccidioidis posadasii(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247protective role in infection modelNA281676512017Pubchem_assay
PRRID_2485NA

Click for more detail

Coccidioidis posadasii(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247protective role in infection modelNA281676512017Pubchem_assay
PRRID_2486NA

Click for more detail

Coccidioidis immitis(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2486NA

Click for more detail

Coccidioidis immitis(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2487NA

Click for more detail

H. capsulatum (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2487NA

Click for more detail

H. capsulatum (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2488NA

Click for more detail

M. audouinii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2488NA

Click for more detail

M. audouinii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2489NA

Click for more detail

Penicillium marneffei (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2489NA

Click for more detail

Penicillium marneffei (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2490NA

Click for more detail

Pneumocystis carnii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2490NA

Click for more detail

Pneumocystis carnii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2491NA

Click for more detail

 Fungi (T. rubrum, yeast)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2491NA

Click for more detail

 Fungi (T. rubrum, yeast)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2492NA

Click for more detail

 Fungi (T. rubrum, yeast)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2492NA

Click for more detail

 Fungi (T. rubrum, yeast)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2493NA

Click for more detail

Trichosporon asahii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2493NA

Click for more detail

Trichosporon asahii (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2494NA

Click for more detail

S. pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantcollectin kidney 1 (CL-K1)C type Lectin (CTL/CLR)MiceNANAQ3SXB8.fastaQ3SXB8272binds to microbes and activates the lectin complement pathwayNA280686632017Pubchem_assay
PRRID_2494NA

Click for more detail

S. pneumoniae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantcollectin kidney 1 (CL-K1)C type Lectin (CTL/CLR)MiceNANAQ3SXB8.fastaQ3SXB8272binds to microbes and activates the lectin complement pathwayNA280686632017Pubchem_assay
PRRID_2499Nigericin

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMicrogliaNAQ8R4B8.fastaQ8R4B81033NLRP3 inflammasome activation in AD modelsNA288015212017Pubchem_assay
PRRID_2499Nigericin

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMicrogliaNAQ8R4B8.fastaQ8R4B81033NLRP3 inflammasome activation in AD modelsNA288015212017Pubchem_assay
PRRID_2500Nigericin

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micecortical neurons (cell culture, stroke model)NAQ8R4B8.fastaQ8R4B81033protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_2500Nigericin

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micecortical neurons (cell culture, stroke model)NAQ8R4B8.fastaQ8R4B81033protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_2501Nigericin

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanBrainNAQ96P20.fastaQ96P201036protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_2501Nigericin

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanBrainNAQ96P20.fastaQ96P201036protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_2502Nigericin

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Ratprimary astrocytesNAD4A523.fastaD4A5231035protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_2502Nigericin

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Ratprimary astrocytesNAD4A523.fastaD4A5231035protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_2503Nigericin

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micesubstantia nigraNAQ8R4B8.fastaQ8R4B81033protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_2503Nigericin

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micesubstantia nigraNAQ8R4B8.fastaQ8R4B81033protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_2521ODN2006

Click for more detail

NA5’-tcgtcgttttgtcgttttgtcgtt-3’24Pattern-associated molecular patterns (PAMPs)Syntheticanti- inflammatory activityToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA291137972017Pubchem_assay
PRRID_2521ODN2006

Click for more detail

NA5’-tcgtcgttttgtcgttttgtcgtt-3’24Pattern-associated molecular patterns (PAMPs)Syntheticanti- inflammatory activityToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanU937 cellsLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA291137972017Pubchem_assay
PRRID_2524ODN2006

Click for more detail

NA5’-tcgtcgttttgtcgttttgtcgtt-3’24Pattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanPeripheral blood mononuclear cells (PBMC)Leucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290393482017Pubchem_assay
PRRID_2524ODN2006

Click for more detail

NA5’-tcgtcgttttgtcgttttgtcgtt-3’24Pattern-associated molecular patterns (PAMPs)SyntheticNAToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanPeripheral blood mononuclear cells (PBMC)Leucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032NANA290393482017Pubchem_assay
PRRID_2527P2Y2PalIC2

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2527P2Y2PalIC2

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2528P2Y2PalIC3

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2528P2Y2PalIC3

Click for more detail

NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2529Palmitic acid

Click for more detail

NACCCCCCCCCCCCCCCC(=O)ONAPattern-associated molecular patterns (PAMPs)NaturalPA may func- tion as a dietary immune modifier (DIM) resulting in the induction of chronic inflammation, such as that seen in type 2 diabetes.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanDendritic cellLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839production of IL-1β in human DCs through an inflammasome dependent mechanismqRT-PCR284639852017Pubchem_assay
PRRID_2529Palmitic acid

Click for more detail

NACCCCCCCCCCCCCCCC(=O)ONAPattern-associated molecular patterns (PAMPs)NaturalPA may func- tion as a dietary immune modifier (DIM) resulting in the induction of chronic inflammation, such as that seen in type 2 diabetes.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanDendritic cellLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839production of IL-1β in human DCs through an inflammasome dependent mechanismqRT-PCR284639852017Pubchem_assay
PRRID_2532particulate b-glucan

Click for more detail

NAC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANABlocking, non activatingNA281676512017NA
PRRID_2532particulate b-glucan

Click for more detail

NAC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANABlocking, non activatingNA281676512017NA
PRRID_2533pathogen ssRNA

Click for more detail

flu virus, SeV and bacteriaNANAPattern-associated molecular patterns (PAMPs)Naturalpotassium efflux-NEK7 involved NLRP3 inflammasome complexNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanCytoplasm. Ubiquitously expressedNAQ96P20.fastaQ96P201036ASC-inflammasome- caspase-1-IL-1/IL-18NA283749032017Pubchem_assay
PRRID_2533pathogen ssRNA

Click for more detail

flu virus, SeV and bacteriaNANAPattern-associated molecular patterns (PAMPs)Naturalpotassium efflux-NEK7 involved NLRP3 inflammasome complexNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanCytoplasm. Ubiquitously expressedNAQ96P20.fastaQ96P201036ASC-inflammasome- caspase-1-IL-1/IL-18NA283749032017Pubchem_assay
PRRID_2550periplasmic flagella

Click for more detail

T. denticola (Bacteria)MKKTFILVAMAFLLMGAVAVAEEAIIIDFALLNADIIADPNGKMTQNRRTVMDYGKVAGASYTDEQKALMRTSLALEQWDVELNSSAQNPLSVATSTIKEAEVRAEGEKFAGQKLMGVRILFPEWTNNANAKIKPGFLIPAYEKMAQVDDQGNLQEPTAEDKASGKSRFEDGYGVVRNTGVIKSIAVNTYGMNFPHGLYVLLRDQNNVVKRYFMGYLLFDGWRELVWNNPSYIANVKSRELRLYPVYPTALPHVAFEGFLITRDAAHDGGDAIAYFKDVKIIYDKAVLTTVRDFADEDLWGIQEERETKRKKIEVEKFGHTQVLRFLEQEKMATEEGFTPSEGSEKNTQ349Pattern-associated molecular patterns (PAMPs)Naturalperiodontal inflammation;Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA290848992017Pubchem_assay
PRRID_2550periplasmic flagella

Click for more detail

T. denticola (Bacteria)MKKTFILVAMAFLLMGAVAVAEEAIIIDFALLNADIIADPNGKMTQNRRTVMDYGKVAGASYTDEQKALMRTSLALEQWDVELNSSAQNPLSVATSTIKEAEVRAEGEKFAGQKLMGVRILFPEWTNNANAKIKPGFLIPAYEKMAQVDDQGNLQEPTAEDKASGKSRFEDGYGVVRNTGVIKSIAVNTYGMNFPHGLYVLLRDQNNVVKRYFMGYLLFDGWRELVWNNPSYIANVKSRELRLYPVYPTALPHVAFEGFLITRDAAHDGGDAIAYFKDVKIIYDKAVLTTVRDFADEDLWGIQEERETKRKKIEVEKFGHTQVLRFLEQEKMATEEGFTPSEGSEKNTQ349Pattern-associated molecular patterns (PAMPs)Naturalperiodontal inflammation;Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA290848992017Pubchem_assay
PRRID_2552phosphatidyl-myo-inositol mannosides (PIM)

Click for more detail

Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanTHP‚Äê1 macrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017Pubchem_assay
PRRID_2552phosphatidyl-myo-inositol mannosides (PIM)

Click for more detail

Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanTHP‚Äê1 macrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017Pubchem_assay
PRRID_2553phosphatidyl-myo-inositol mannosides (PIM)

Click for more detail

Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsCR3Complement ReceptorHumanTHP‚Äê1 macrophagesNANANANANATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017NA
PRRID_2553phosphatidyl-myo-inositol mannosides (PIM)

Click for more detail

Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsCR3Complement ReceptorHumanTHP‚Äê1 macrophagesNANANANANATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017NA
PRRID_2580R837

Click for more detail

SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) NANAPattern-associated molecular patterns (PAMPs)NaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomes. Innate immune cells except neutrophils and pDCsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2580R837

Click for more detail

SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) NANAPattern-associated molecular patterns (PAMPs)NaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomes. Innate immune cells except neutrophils and pDCsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2581R848

Click for more detail

SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) NANAPattern-associated molecular patterns (PAMPs)NaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanEndosomes. pDCs and B cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2581R848

Click for more detail

SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) NANAPattern-associated molecular patterns (PAMPs)NaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanEndosomes. pDCs and B cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2582R848

Click for more detail

SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) NANAPattern-associated molecular patterns (PAMPs)NaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanEndosomes. Monocytes, macrophages and cDCsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2582R848

Click for more detail

SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) NANAPattern-associated molecular patterns (PAMPs)NaturalZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanEndosomes. Monocytes, macrophages and cDCsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_2583rb-dsRNA

Click for more detail

Rice- bran (plant)NANAPattern-associated molecular patterns (PAMPs)Naturalactivate caspase 1 via TRIF, resulting in the release of IL-1b and LDHToll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ99MB1.fastaQ99MB1905Caspase 1 activation is specifically induced by TLR3 signaling through TRIF/RIPK/ FADD, resulting in activation of the NLRP3 inflammasomeRT-qPCR288480652017Pubchem_assay
PRRID_2583rb-dsRNA

Click for more detail

Rice- bran (plant)NANAPattern-associated molecular patterns (PAMPs)Naturalactivate caspase 1 via TRIF, resulting in the release of IL-1b and LDHToll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ99MB1.fastaQ99MB1905Caspase 1 activation is specifically induced by TLR3 signaling through TRIF/RIPK/ FADD, resulting in activation of the NLRP3 inflammasomeRT-qPCR288480652017Pubchem_assay