Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_1875TDM

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M. tuberculosis, S. pneumoniae, K. pneumo- niae, H. pylori, C. albicans, Malassezia spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincleC type Lectin (CTL/CLR)HumanNANANANANARecognition of pathogens and necrotic cells; Induction of cytokine productionNA279999922016NA
PRRID_1875TDM

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M. tuberculosis, S. pneumoniae, K. pneumo- niae, H. pylori, C. albicans, Malassezia spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincleC type Lectin (CTL/CLR)HumanNANANANANARecognition of pathogens and necrotic cells; Induction of cytokine productionNA279999922016NA
PRRID_1876Tenascin C

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NAMGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETS2201Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAActivate NF-KbNA272933182016NA
PRRID_1876Tenascin C

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NAMGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETS2201Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAActivate NF-KbNA272933182016NA
PRRID_1877TLR1–TLR2 heterodimer

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Zebrafishplasma membraneextracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainA0A0R4IW15.fastaA0A0R4IW15795induce IFN expressionNA277214562016Pubchem_assay
PRRID_1877TLR1–TLR2 heterodimer

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Zebrafishplasma membraneextracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainA0A0R4IW15.fastaA0A0R4IW15795induce IFN expressionNA277214562016Pubchem_assay
PRRID_1879Unknown

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)ColitisNANANANANA↑ TGF-β via TLR4-dependent mannerNA271202222016NA
PRRID_1879Unknown

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)ColitisNANANANANA↑ TGF-β via TLR4-dependent mannerNA271202222016NA
PRRID_1880Unknown

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUK6.fastaQ9QUK6835Suppression of DC response to TRLsNA271202222016Pubchem_assay
PRRID_1880Unknown

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Helminths (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)NANAQ9QUK6.fastaQ9QUK6835Suppression of DC response to TRLsNA271202222016Pubchem_assay
PRRID_1881Unknown

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H. polygyrus (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micesmall intestineNAQ9QUK6.fastaQ9QUK6835↑ TGF-β via TLR 4-dependent mannerNA271202222016Pubchem_assay
PRRID_1881Unknown

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H. polygyrus (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micesmall intestineNAQ9QUK6.fastaQ9QUK6835↑ TGF-β via TLR 4-dependent mannerNA271202222016Pubchem_assay
PRRID_1882Unmethylated CpG DNA

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Bacterial, viral genomeNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceDendritic cellextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ9NR96.fastaQ9NR961032dendritic cells activation for innate and adaptive immunityNA277566042016Pubchem_assay
PRRID_1882Unmethylated CpG DNA

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Bacterial, viral genomeNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceDendritic cellextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ9NR96.fastaQ9NR961032dendritic cells activation for innate and adaptive immunityNA277566042016Pubchem_assay
PRRID_1883VP19 WSSV envelope protein

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white spot syndrome virus (WSSV)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMjSRCScavenger receptor (SR)Marsupenaeus japonicusHemocytestwo CCP domains, a MAM domain, a transmembrane region and an intracellular regionA0A1L2DC21.fastaA0A1L2DC21692antiviral role by enhancing hemo- cytes phagocytosis of WSSV in shrimp.NA280273192016Pubchem_assay
PRRID_1883VP19 WSSV envelope protein

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white spot syndrome virus (WSSV)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMjSRCScavenger receptor (SR)Marsupenaeus japonicusHemocytestwo CCP domains, a MAM domain, a transmembrane region and an intracellular regionA0A1L2DC21.fastaA0A1L2DC21692antiviral role by enhancing hemo- cytes phagocytosis of WSSV in shrimp.NA280273192016Pubchem_assay
PRRID_1884α-Mannose

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M. tuberculosis, S. enterica, S. mansoni, C. albicans, A. fumigatus, Malassezia spp.(Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-2C type Lectin (CTL/CLR)HumanNANAQ6EIG7.fastaQ6EIG7209Pathogen recognition; antigen uptakeNA279999922016Pubchem_assay
PRRID_1884α-Mannose

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M. tuberculosis, S. enterica, S. mansoni, C. albicans, A. fumigatus, Malassezia spp.(Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-2C type Lectin (CTL/CLR)HumanNANAQ6EIG7.fastaQ6EIG7209Pathogen recognition; antigen uptakeNA279999922016Pubchem_assay
PRRID_1885α-Mannose

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M. tuberculosis, S. pneumoniae, K. pneumo- niae, H. pylori, C. albicans, Malassezia spp.(Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincleC type Lectin (CTL/CLR)HumanNANANANANARecognition of pathogens and necrotic cells; Induction of cytokine productionNA279999922016NA
PRRID_1885α-Mannose

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M. tuberculosis, S. pneumoniae, K. pneumo- niae, H. pylori, C. albicans, Malassezia spp.(Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincleC type Lectin (CTL/CLR)HumanNANANANANARecognition of pathogens and necrotic cells; Induction of cytokine productionNA279999922016NA
PRRID_1886β -1,3-glucan

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Mycobacterium spp., L. infantum, C. albicans P. carinii, A. fumigatus, C. neoformansC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1C type Lectin (CTL/CLR)HumanNANAQ9BXN2.fastaQ9BXN2247Pathogen recognition; T cell differentiationNA279999922016Pubchem_assay
PRRID_1886β -1,3-glucan

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Mycobacterium spp., L. infantum, C. albicans P. carinii, A. fumigatus, C. neoformansC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1C type Lectin (CTL/CLR)HumanNANAQ9BXN2.fastaQ9BXN2247Pathogen recognition; T cell differentiationNA279999922016Pubchem_assay
PRRID_1906Aeromonas hydrophila

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalPathogenic infectionCcToll-like receptor (TLR18)Toll-like receptor (TLR)Common Carp (Cyprinus carpio L)head kidney, foregut, hindgut and skin.LRR motifs, a transmembrane region and a TIR domainNANANANAReal-time PCR291113942017NA
PRRID_1906Aeromonas hydrophila

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalPathogenic infectionCcToll-like receptor (TLR18)Toll-like receptor (TLR)Common Carp (Cyprinus carpio L)head kidney, foregut, hindgut and skin.LRR motifs, a transmembrane region and a TIR domainNANANANAReal-time PCR291113942017NA
PRRID_1907Ag85 complex

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Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanTHP‚Äê1 macrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017Pubchem_assay
PRRID_1907Ag85 complex

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Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanTHP‚Äê1 macrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017Pubchem_assay
PRRID_1908Ag85 complex

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Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsCR3Complement ReceptorHumanTHP‚Äê1 macrophagesNANANANANATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017NA
PRRID_1908Ag85 complex

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Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsCR3Complement ReceptorHumanTHP‚Äê1 macrophagesNANANANANATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017NA
PRRID_1916analog poly I:C

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MCMV, HSV-1, EMCV, WNV,and enteroviruses (virus)NANAPattern-associated molecular patterns (PAMPs)SyntheticdsRNA induced dimerizationToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomes. Innate immune cells except neutrophils and pDCsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904TRIF-TRAF3-TBK1/ IKKe-IRF3. TRIF-TRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_1916analog poly I:C

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MCMV, HSV-1, EMCV, WNV,and enteroviruses (virus)NANAPattern-associated molecular patterns (PAMPs)SyntheticdsRNA induced dimerizationToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomes. Innate immune cells except neutrophils and pDCsLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904TRIF-TRAF3-TBK1/ IKKe-IRF3. TRIF-TRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_1924ATI-2341

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_1924ATI-2341

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_1946b-1,3-glucans.

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Candida glabrata(fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalBinding and activation of Dectin -1Dectin-1C type Lectin (CTL/CLR)MiceMacrophagesNAQ9BXN2.fastaQ9BXN2247activation of the NF-κB and MAPK pathwaysBinding assay286585922017Pubchem_assay
PRRID_1946b-1,3-glucans.

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Candida glabrata(fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalBinding and activation of Dectin -1Dectin-1C type Lectin (CTL/CLR)MiceMacrophagesNAQ9BXN2.fastaQ9BXN2247activation of the NF-κB and MAPK pathwaysBinding assay286585922017Pubchem_assay
PRRID_1947b-Gentiobiosyl diaglycerides

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Mtb H37Ra (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1947b-Gentiobiosyl diaglycerides

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Mtb H37Ra (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1948b-Gentiobiosyl diaglycerides

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Mtb H37Ra (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1948b-Gentiobiosyl diaglycerides

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Mtb H37Ra (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1952Bacterial MDP

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RSV, IAV, and HCMV (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalLikely tetramerization into washer- locker structureNucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)HumanCytoplasm. Macrophages, monocytes, Paneth cells, DCsNAQ9HC29.fastaQ9HC291040RIP2-IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_1952Bacterial MDP

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RSV, IAV, and HCMV (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalLikely tetramerization into washer- locker structureNucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)HumanCytoplasm. Macrophages, monocytes, Paneth cells, DCsNAQ9HC29.fastaQ9HC291040RIP2-IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_1963Brartemicin

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRNANANANANANAProtective role in infection modelNA281676512017NA
PRRID_1963Brartemicin

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRNANANANANANAProtective role in infection modelNA281676512017NA
PRRID_1965C. albicans

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1965C. albicans

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1966C. albicans

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1966C. albicans

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1972Chitin

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V.dahliae (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalActivate PTI( PAMP triggered immunity )Lyp1Pattern recognition receptor (PRR)CottonPlasma memebraneLysin motif (LysM) domainNANANAactivate downstream defense processes, and enhance resistance to V. dahliae.NA288701722017NA
PRRID_1972Chitin

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V.dahliae (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalActivate PTI( PAMP triggered immunity )Lyp1Pattern recognition receptor (PRR)CottonPlasma memebraneLysin motif (LysM) domainNANANAactivate downstream defense processes, and enhance resistance to V. dahliae.NA288701722017NA
PRRID_1973Chitin

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V.dahliae (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalActivate PTI( PAMP triggered immunity )Lyk7LysMCottonPlasma memebraneLysin motif (LysM) domainNANANAactivate downstream defense processes, and enhance resistance to V. dahliae.NA288701722017NA
PRRID_1973Chitin

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V.dahliae (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalActivate PTI( PAMP triggered immunity )Lyk7LysMCottonPlasma memebraneLysin motif (LysM) domainNANANAactivate downstream defense processes, and enhance resistance to V. dahliae.NA288701722017NA
PRRID_1974Chitin

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V.dahliae (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalActivate PTI( PAMP triggered immunity )LysMe3Pattern recognition receptor (PRR)CottonPlasma memebraneLysin motif (LysM) domainNANANAactivate downstream defense processes, and enhance resistance to V. dahliae.NA288701722017NA
PRRID_1974Chitin

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V.dahliae (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalActivate PTI( PAMP triggered immunity )LysMe3Pattern recognition receptor (PRR)CottonPlasma memebraneLysin motif (LysM) domainNANANAactivate downstream defense processes, and enhance resistance to V. dahliae.NA288701722017NA
PRRID_1975Chitin

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protozoa, fungi, arthropods, and nematodes (others)NANAPattern-associated molecular patterns (PAMPs)NaturalChitin induces cy- tokine production, leukocyte recruitment, and alternative mac- rophage activationToll-like receptor 2 (TLR2)Toll-like receptor (TLR) HumanLungs and gutTIR domainO60603.fastaO60603784Activate immune cells to induce cytokine productionNA282515812017Pubchem_assay
PRRID_1975Chitin

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protozoa, fungi, arthropods, and nematodes (others)NANAPattern-associated molecular patterns (PAMPs)NaturalChitin induces cy- tokine production, leukocyte recruitment, and alternative mac- rophage activationToll-like receptor 2 (TLR2)Toll-like receptor (TLR) HumanLungs and gutTIR domainO60603.fastaO60603784Activate immune cells to induce cytokine productionNA282515812017Pubchem_assay
PRRID_1976Chitin

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protozoa, fungi, arthropods, and nematodes (others)NANAPattern-associated molecular patterns (PAMPs)NaturalChitin induces cy- tokine production, leukocyte recruitment, and alternative mac- rophage activationDectin-1C type Lectin (CTL/CLR) HumanLungs and gutNANANANAActivate immune cells to induce cytokine productionNA282515812017NA
PRRID_1976Chitin

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protozoa, fungi, arthropods, and nematodes (others)NANAPattern-associated molecular patterns (PAMPs)NaturalChitin induces cy- tokine production, leukocyte recruitment, and alternative mac- rophage activationDectin-1C type Lectin (CTL/CLR) HumanLungs and gutNANANANAActivate immune cells to induce cytokine productionNA282515812017NA
PRRID_1977Chlyamydia components

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Chlamydia(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulant and cause chlaymydia infections.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANAleucine-rich repeat (LRR), hydrophobic transmembrane and cytoplasmic Toll/interleukin-1 receptor (TIR) domainsNANANApromote transcription from pro-inflammatory cytokines including IL-1 and IL-12NA285040912017NA
PRRID_1977Chlyamydia components

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Chlamydia(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulant and cause chlaymydia infections.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANAleucine-rich repeat (LRR), hydrophobic transmembrane and cytoplasmic Toll/interleukin-1 receptor (TIR) domainsNANANApromote transcription from pro-inflammatory cytokines including IL-1 and IL-12NA285040912017NA
PRRID_1978Cholesterol crystal

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Endogenous (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNAVEGQ motifQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1978Cholesterol crystal

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Endogenous (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNAVEGQ motifQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1983CL075

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)SyntheticZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanEndosomes. Monocytes, macrophages and cDCsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_1983CL075

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SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)SyntheticZ-loop proteolytic cleavage, and receptor dimer conformational changeToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanEndosomes. Monocytes, macrophages and cDCsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_1986Cladophialophora carrionii

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1986Cladophialophora carrionii

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1989Curdlan

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANABlocking, non activatingNA281676512017NA
PRRID_1989Curdlan

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRInfection modelNANANANANABlocking, non activatingNA281676512017NA
PRRID_1990Cyclopropane–fatty acid a-glucosyl diglyceride

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Lactobacillus plantarum (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1990Cyclopropane–fatty acid a-glucosyl diglyceride

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Lactobacillus plantarum (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1994Dead cells

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Endogenous (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_1994Dead cells

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Endogenous (others)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2021F2M2

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2021F2M2

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2022F2Pal10

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2022F2Pal10

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2023F2Pal12

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2023F2Pal12

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2024F2Pal16

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2024F2Pal16

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NANANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorFPR2(Formyl peptide Receptor2)Pattern recognition receptor (PRR)HumanNeutrophilsSeven alpha helical transmembrane domainsP25090.fastaP25090351tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation,Neutrophil NADPH oxidase assay288810792017Pubchem_assay
PRRID_2034FlaB1, FlaB2 or FlaB3

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T. pallidum (others)NANAPattern-associated molecular patterns (PAMPs)Naturalcapable of triggering MMP-9 and MMP-13 expression in humanToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanKeratinocytesLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NAELISA289825392017Pubchem_assay
PRRID_2034FlaB1, FlaB2 or FlaB3

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T. pallidum (others)NANAPattern-associated molecular patterns (PAMPs)Naturalcapable of triggering MMP-9 and MMP-13 expression in humanToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanKeratinocytesLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858NAELISA289825392017Pubchem_assay
PRRID_2052Fonsecaea pedrosoi

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2052Fonsecaea pedrosoi

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2053Fonsecaea monophora

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2053Fonsecaea monophora

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2054Fonsecaea compacta

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2054Fonsecaea compacta

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRMiceNANAQ9R0Q8.fastaQ9R0Q8214Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2055Fonsecaea pedrosoi

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2055Fonsecaea pedrosoi

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2071Germ tubes

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Aspergillus fumigatus(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244protective role in infection modelNA281676512017Pubchem_assay
PRRID_2071Germ tubes

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Aspergillus fumigatus(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244protective role in infection modelNA281676512017Pubchem_assay
PRRID_2072Germ tubes

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Aspergillus fumigatus(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2072Germ tubes

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Aspergillus fumigatus(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2079Fonsecaea monophora

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2079Fonsecaea monophora

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2080Fonsecaea compacta

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2080Fonsecaea compacta

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NANANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincle(Clec4e)Syk-coupled CLRHumanNANAQ9ULY5.fastaQ9ULY5219Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2085Glycans

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Bacteria(Gram negative, Gram positive)NANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorMjCC-CLC type Lectin (CTL/CLR)kuruma shrimp (Marsupenaeus japonicus)intestineC-type carbohydrate recogni- tion domainNANANACTL acti- vates the JAK/STAT signaling pathway and regulates AMP expression.Recombinanat Protein Binding Assay289310612017NA
PRRID_2085Glycans

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Bacteria(Gram negative, Gram positive)NANAPattern-associated molecular patterns (PAMPs)Naturalinnate immunity elicitorMjCC-CLC type Lectin (CTL/CLR)kuruma shrimp (Marsupenaeus japonicus)intestineC-type carbohydrate recogni- tion domainNANANACTL acti- vates the JAK/STAT signaling pathway and regulates AMP expression.Recombinanat Protein Binding Assay289310612017NA
PRRID_2086Glycans

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantHaCTL3C type Lectin (CTL/CLR)Helicoverpa armigeraHemocytesNANANANAHaCTL3 enhances hemocytic encapsulation and melanizationqRT-PCR285720002017NA
PRRID_2086Glycans

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantHaCTL3C type Lectin (CTL/CLR)Helicoverpa armigeraHemocytesNANANANAHaCTL3 enhances hemocytic encapsulation and melanizationqRT-PCR285720002017NA