Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1601	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	immune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	Functional assay	24748512	2014	Pubchem_assay
PRRID_1601	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	immune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	Functional assay	24748512	2014	Pubchem_assay
PRRID_1602	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	immune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	P58682.fasta	P58682	1032	important role in the immune response to viral infection	Functional assay	24748512	2014	Pubchem_assay
PRRID_1602	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	immune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	P58682.fasta	P58682	1032	important role in the immune response to viral infection	Functional assay	24748512	2014	Pubchem_assay
PRRID_1603	resistin (RSTN)] Click for more detail	Primates, rodents (others)	MKNLSFPLLFLFFLVPELLGSSMPLCPIDEAIDKKIKQDFNSLFPNAIKNIGLNCWTVSSRGKLASCPEGTAVLSCSCGSACGSWDIREEKVCHCQCARIDWTAARCCKLQVAS	114	Pattern-associated molecular patterns (PAMPs)	Natural	associated with atherosclerosis.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24823872	2014	Pubchem_assay
PRRID_1603	resistin (RSTN)] Click for more detail	Primates, rodents (others)	MKNLSFPLLFLFFLVPELLGSSMPLCPIDEAIDKKIKQDFNSLFPNAIKNIGLNCWTVSSRGKLASCPEGTAVLSCSCGSACGSWDIREEKVCHCQCARIDWTAARCCKLQVAS	114	Pattern-associated molecular patterns (PAMPs)	Natural	associated with atherosclerosis.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24823872	2014	Pubchem_assay
PRRID_1647	Tenascin C Click for more detail	Human (others)	MGAVTWLLPGIFLALFALTPEGGVLKKIIRHKRESGLNMTLPEENQPVVFNHIYNIKLPMGSQCSVDLESASGEKDLTPTPESSGSFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELELLVSSLREQCTMGTGCCLQPAEGRLDTRPFCSGRGNFSAEGCGCVCEPGWKGPNCSEPDCPGNCNLRGQCLDGQCICDEGFTGEDCSQLACPNDCNDQGRCVNGVCVCFEGYAGPDCGLEVCPVPCSEEHGMCVDGRCVCKDGFAGEDCNEPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGELTCPNDCQGRGQCEEGQCVCNEGFAGADCSEKRCPADCHHRGRCLNGQCECDDGFTGADCGDLQCPNGCSGHGRCVNGQCVCDEGYTGEDCSQRRCPNDCHNRGLCVQGKCICEQGFKGFDCSEMSCPNDCHQHGRCVNGMCICDDDYTGEDCRDRRCPRDCSQRGRCVDGQCICEDGFTGPDCAELSCPSDCHGHGRCVNGQCICHEGFTGKDCKEQRCPSDCHGQGRCEDGQCICHEGFTGLDCGQRSCPNDCSNQGQCVSGRCICNEGYTGIDCSEVSPPKDLIVTEVTEETVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENKRSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKKVTTTRLDAPSHIEVKDVTDTTALITWFKPLAEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLRPDTEYEVSLISRRVDMASNPAKETFITGLDAPRNLRRVSQTDNSITLEWRNVKADIDSYRIKYAPISGGDHAEIDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKGDKESDPATINAATEIDAPKDLRVSETTQDS	2110	Pattern-associated molecular patterns (PAMPs)	Natural	TN-C clearly plays a role in cell signaling as evidenced by its ability to be induced during events such as trauma, inflammation, or cancer development.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	Cell Surface (Exogenous)	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24830024	2014	Pubchem_assay
PRRID_1647	Tenascin C Click for more detail	Human (others)	MGAVTWLLPGIFLALFALTPEGGVLKKIIRHKRESGLNMTLPEENQPVVFNHIYNIKLPMGSQCSVDLESASGEKDLTPTPESSGSFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELELLVSSLREQCTMGTGCCLQPAEGRLDTRPFCSGRGNFSAEGCGCVCEPGWKGPNCSEPDCPGNCNLRGQCLDGQCICDEGFTGEDCSQLACPNDCNDQGRCVNGVCVCFEGYAGPDCGLEVCPVPCSEEHGMCVDGRCVCKDGFAGEDCNEPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGELTCPNDCQGRGQCEEGQCVCNEGFAGADCSEKRCPADCHHRGRCLNGQCECDDGFTGADCGDLQCPNGCSGHGRCVNGQCVCDEGYTGEDCSQRRCPNDCHNRGLCVQGKCICEQGFKGFDCSEMSCPNDCHQHGRCVNGMCICDDDYTGEDCRDRRCPRDCSQRGRCVDGQCICEDGFTGPDCAELSCPSDCHGHGRCVNGQCICHEGFTGKDCKEQRCPSDCHGQGRCEDGQCICHEGFTGLDCGQRSCPNDCSNQGQCVSGRCICNEGYTGIDCSEVSPPKDLIVTEVTEETVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENKRSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKKVTTTRLDAPSHIEVKDVTDTTALITWFKPLAEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLRPDTEYEVSLISRRVDMASNPAKETFITGLDAPRNLRRVSQTDNSITLEWRNVKADIDSYRIKYAPISGGDHAEIDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKGDKESDPATINAATEIDAPKDLRVSETTQDS	2110	Pattern-associated molecular patterns (PAMPs)	Natural	TN-C clearly plays a role in cell signaling as evidenced by its ability to be induced during events such as trauma, inflammation, or cancer development.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	Cell Surface (Exogenous)	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24830024	2014	Pubchem_assay
PRRID_1648	Tenascin C Click for more detail	Human (others)	MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETS	2201	Pattern-associated molecular patterns (PAMPs)	Natural	associated with chronic inflammatory conditions	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	fibrinogen-like domain (FBG)	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24823872	2014	Pubchem_assay
PRRID_1648	Tenascin C Click for more detail	Human (others)	MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETS	2201	Pattern-associated molecular patterns (PAMPs)	Natural	associated with chronic inflammatory conditions	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	fibrinogen-like domain (FBG)	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24823872	2014	Pubchem_assay
PRRID_1673	Uropathogenic E. coli Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	elicit innate immune response	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	Cell Surface (Exogenous)	Q6R5P0.fasta	Q6R5P0	926	TLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion.	NA	24830024	2014	Pubchem_assay
PRRID_1673	Uropathogenic E. coli Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	elicit innate immune response	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	Cell Surface (Exogenous)	Q6R5P0.fasta	Q6R5P0	926	TLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion.	NA	24830024	2014	Pubchem_assay
PRRID_1674	VTX-2337 Click for more detail	mimics viral single-stranded ribonucleic acid (ssRNA) (virus)	CCCN(CCC)C(=O)C1=CC2=C(C=C(C=C2)C3=CC=C(C=C3)C(=O)N4CCCC4)N=C(C1)N	NA	Pattern-associated molecular patterns (PAMPs)	Natural	stimulates TLR8	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice (Murine)	TLR8 is expressed on mDCs, monocytes, and NK cells in humans	cell compartment	P58682.fasta	P58682	1032	TLR8 is expected to stimulate the release of distinct inflammatory mediators, including Th1- polarizing cytokines, chemokines, and other acute phase proteins	NA	24807889	2014	Pubchem_assay
PRRID_1674	VTX-2337 Click for more detail	mimics viral single-stranded ribonucleic acid (ssRNA) (virus)	CCCN(CCC)C(=O)C1=CC2=C(C=C(C=C2)C3=CC=C(C=C3)C(=O)N4CCCC4)N=C(C1)N	NA	Pattern-associated molecular patterns (PAMPs)	Natural	stimulates TLR8	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice (Murine)	TLR8 is expressed on mDCs, monocytes, and NK cells in humans	cell compartment	P58682.fasta	P58682	1032	TLR8 is expected to stimulate the release of distinct inflammatory mediators, including Th1- polarizing cytokines, chemokines, and other acute phase proteins	NA	24807889	2014	Pubchem_assay
PRRID_1675	VTX-2337 Click for more detail	mimics viral single-stranded ribonucleic acid (ssRNA) (virus)	CCCN(CCC)C(=O)C1=CC2=C(C=C(C=C2)C3=CC=C(C=C3)C(=O)N4CCCC4)N=C(C1)N	NA	Pattern-associated molecular patterns (PAMPs)	Natural	stimulates TLR8	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	TLR8 is expressed on mDCs, monocytes, and NK cells in humans	cell compartment	Q9NR97.fasta	Q9NR97	1041	TLR8 is expected to stimulate the release of distinct inflammatory mediators, including Th1- polarizing cytokines, chemokines, and other acute phase proteins	NA	24807889	2014	Pubchem_assay
PRRID_1675	VTX-2337 Click for more detail	mimics viral single-stranded ribonucleic acid (ssRNA) (virus)	CCCN(CCC)C(=O)C1=CC2=C(C=C(C=C2)C3=CC=C(C=C3)C(=O)N4CCCC4)N=C(C1)N	NA	Pattern-associated molecular patterns (PAMPs)	Natural	stimulates TLR8	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	TLR8 is expressed on mDCs, monocytes, and NK cells in humans	cell compartment	Q9NR97.fasta	Q9NR97	1041	TLR8 is expected to stimulate the release of distinct inflammatory mediators, including Th1- polarizing cytokines, chemokines, and other acute phase proteins	NA	24807889	2014	Pubchem_assay
PRRID_1704	NS1 protein Click for more detail	Dengue virus(virus)	DMGYWIESEKNETWKLARASFIEVKTCIWPKSHTLWSNGVLESEMIIPKIYGGPISQHNYRPGYFTQTAGPWHLGKLELDFDLCEGTTVVVDEHCGNRGPSLRTTTVTGKIIHEWCCRSCTLPPLRFKGEDGCWYGM	137	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	NA	O00206.fasta	O00206	839	NA	NA	27293318	2016	Pubchem_assay
PRRID_1704	NS1 protein Click for more detail	Dengue virus(virus)	DMGYWIESEKNETWKLARASFIEVKTCIWPKSHTLWSNGVLESEMIIPKIYGGPISQHNYRPGYFTQTAGPWHLGKLELDFDLCEGTTVVVDEHCGNRGPSLRTTTVTGKIIHEWCCRSCTLPPLRFKGEDGCWYGM	137	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	NA	O00206.fasta	O00206	839	NA	NA	27293318	2016	Pubchem_assay
PRRID_1705	NS1 protein Click for more detail	Dengue virus(virus)	DMGYWIESEKNETWKLARASFIEVKTCIWPKSHTLWSNGVLESEMIIPKIYGGPISQHNYRPGYFTQTAGPWHLGKLELDFDLCEGTTVVVDEHCGNRGPSLRTTTVTGKIIHEWCCRSCTLPPLRFKGEDGCWYGM	137	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1705	NS1 protein Click for more detail	Dengue virus(virus)	DMGYWIESEKNETWKLARASFIEVKTCIWPKSHTLWSNGVLESEMIIPKIYGGPISQHNYRPGYFTQTAGPWHLGKLELDFDLCEGTTVVVDEHCGNRGPSLRTTTVTGKIIHEWCCRSCTLPPLRFKGEDGCWYGM	137	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1707	3M-002 Click for more detail	NA	CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	RDToll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Chinese raccoon dog	peripheral blood mononuclear cells (PBMCs)	19 leucine-rich repeats (LRRs) in the extracel- lular domain and a cytoplasmic TIR domain	NA	NA	NA	proinflammatory cytokines TNF- a and IFN-a upregulation	qRT-PCR	27481482	2016	NA
PRRID_1707	3M-002 Click for more detail	NA	CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	RDToll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Chinese raccoon dog	peripheral blood mononuclear cells (PBMCs)	19 leucine-rich repeats (LRRs) in the extracel- lular domain and a cytoplasmic TIR domain	NA	NA	NA	proinflammatory cytokines TNF- a and IFN-a upregulation	qRT-PCR	27481482	2016	NA
PRRID_1708	Agonist Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	immunostimulant	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	NA	NA	NA	Controversial (induce or inhibit)	NA	27120222	2016	NA
PRRID_1708	Agonist Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	immunostimulant	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	NA	NA	NA	Controversial (induce or inhibit)	NA	27120222	2016	NA
PRRID_1709	Agonist Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q99MB1.fasta	Q99MB1	905	Controversial (induce or inhibit)	NA	27120222	2016	Pubchem_assay
PRRID_1709	Agonist Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q99MB1.fasta	Q99MB1	905	Controversial (induce or inhibit)	NA	27120222	2016	Pubchem_assay
PRRID_1710	Agonist Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	NA	NA	NA	attenuates asthma	NA	27120222	2016	NA
PRRID_1710	Agonist Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	NA	NA	NA	attenuates asthma	NA	27120222	2016	NA
PRRID_1711	Agonist Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	NA	NA	NA	Attenuate or inhibit	NA	27120222	2016	NA
PRRID_1711	Agonist Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	NA	NA	NA	Attenuate or inhibit	NA	27120222	2016	NA
PRRID_1712	Agonist Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9NR96.fasta	Q9NR96	1032	Attenuate or inhibit	NA	27120222	2016	Pubchem_assay
PRRID_1712	Agonist Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9NR96.fasta	Q9NR96	1032	Attenuate or inhibit	NA	27120222	2016	Pubchem_assay
PRRID_1713	Agonist Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Controversial (induce or inhibit)	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	NA	NA	NA	Expansion of Tregs in OVA-induced asthma model	NA	27120222	2016	NA
PRRID_1713	Agonist Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Controversial (induce or inhibit)	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	NA	NA	NA	Expansion of Tregs in OVA-induced asthma model	NA	27120222	2016	NA
PRRID_1714	Agonist Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q99MB1.fasta	Q99MB1	905	NFŒ∫B‚Üë	NA	27120222	2016	Pubchem_assay
PRRID_1714	Agonist Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q99MB1.fasta	Q99MB1	905	NFŒ∫B‚Üë	NA	27120222	2016	Pubchem_assay
PRRID_1716	b-1,3-glucans. Click for more detail	Bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP)	Pattern recognition receptor (PRR)	Fenneropenaeus merguiensis	Hepatopancreas	NA	NA	NA	NA	Activate NF-KB	ELISA	27431930	2016	NA
PRRID_1716	b-1,3-glucans. Click for more detail	Bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP)	Pattern recognition receptor (PRR)	Fenneropenaeus merguiensis	Hepatopancreas	NA	NA	NA	NA	Activate NF-KB	ELISA	27431930	2016	NA
PRRID_1717	Bacterial 23S ribosomal RNA Click for more detail	Bacteria	GGUUAAGCGACUAAGCGUACACGGUGGAUGCCCUGGCAGUCAGAGGCGAUGAAGGACGUGCUAAUCUGCGAUAAGCGUCGGUAAGGUGAUAUGAACCGUUAUAACCGGCGAUUUCCGAAUGGGGAAACCCAGUGUGUUUCGACACACUAUCAUUAACUGAAUCCAUAGGUUAAUGAGGCGAACCGGGGGAACUGAAACAUCUAAGUACCCCGAGGAAAAGAAAUCAACCGAGAUUCCCCCAGUAGCGGCGAGCGAACGGGGAGCAGCCCAGAGCCUGAAUCAGUGUGUGUGUUAGUGGAAGCGUCUGGAAAGGCGUGCGAUACAGGGUGACAGCCCCGUACACAAAAAUGCACAUGCUGUGAGCUCGAUGAGUAGGGCGGGACACGUGGUAUCCUGUCUGAAUAUGGGGGGACCAUCCUCCAAGGCUAAAUACUCCUGACUGACCGAUAGUGAACCAGUACCGUGAGGGAAAGGCGAAAAGAACCCCGGCGAGGGGAGUGAAAAAGAACCUGAAACCGUGUACGUACAAGCAGUGGGAGCACGCUUAGGCGUGUGACUGCGUACCUUUUGUAUAAUGGGUCAGCGACUUAUAUUCUGUAGCAAGGUUAACCGAAUAGGGGAGCCGAAGGGAAACCGAGUCUUAACUGGGCGUUAAGUUGCAGGGUAUAGACCCGAAACCCGGUGAUCUAGCCAUGGGCAGGUUGAAGGUUGGGUAACACUAACUGGAGGACCGAACCGACUAAUGUUGAAAAAUUAGCGGAUGACUUGUGGCUGGGGGUGAAAGGCCAAUCAAACCGGGAGAUAGCUGGUUCUCCCCGAAAGCUAUUUAGGUAGCGCCUCGUGAAUUCAUCUCCGGGGGUAGAGCACUGUUUCGGCAAGGGGGUCAUCCCGACUUACCAACCCGAUGCAAACUGCGAAUACCGGAGAAUGUUAUCACGGGAGACACACGGCGGGUGCUAACGUCCGUCGUGAAGAGGGAAACAACCCAGACCGCCAGCUA	2905	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 13 (TLR13)	Toll-like receptor (TLR)	Mice	Plasma membrane	extracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domain	Q6R5N8.fasta	Q6R5N8	991	Activate NF-KB	NA	27756604	2016	Pubchem_assay
PRRID_1717	Bacterial 23S ribosomal RNA Click for more detail	Bacteria	GGUUAAGCGACUAAGCGUACACGGUGGAUGCCCUGGCAGUCAGAGGCGAUGAAGGACGUGCUAAUCUGCGAUAAGCGUCGGUAAGGUGAUAUGAACCGUUAUAACCGGCGAUUUCCGAAUGGGGAAACCCAGUGUGUUUCGACACACUAUCAUUAACUGAAUCCAUAGGUUAAUGAGGCGAACCGGGGGAACUGAAACAUCUAAGUACCCCGAGGAAAAGAAAUCAACCGAGAUUCCCCCAGUAGCGGCGAGCGAACGGGGAGCAGCCCAGAGCCUGAAUCAGUGUGUGUGUUAGUGGAAGCGUCUGGAAAGGCGUGCGAUACAGGGUGACAGCCCCGUACACAAAAAUGCACAUGCUGUGAGCUCGAUGAGUAGGGCGGGACACGUGGUAUCCUGUCUGAAUAUGGGGGGACCAUCCUCCAAGGCUAAAUACUCCUGACUGACCGAUAGUGAACCAGUACCGUGAGGGAAAGGCGAAAAGAACCCCGGCGAGGGGAGUGAAAAAGAACCUGAAACCGUGUACGUACAAGCAGUGGGAGCACGCUUAGGCGUGUGACUGCGUACCUUUUGUAUAAUGGGUCAGCGACUUAUAUUCUGUAGCAAGGUUAACCGAAUAGGGGAGCCGAAGGGAAACCGAGUCUUAACUGGGCGUUAAGUUGCAGGGUAUAGACCCGAAACCCGGUGAUCUAGCCAUGGGCAGGUUGAAGGUUGGGUAACACUAACUGGAGGACCGAACCGACUAAUGUUGAAAAAUUAGCGGAUGACUUGUGGCUGGGGGUGAAAGGCCAAUCAAACCGGGAGAUAGCUGGUUCUCCCCGAAAGCUAUUUAGGUAGCGCCUCGUGAAUUCAUCUCCGGGGGUAGAGCACUGUUUCGGCAAGGGGGUCAUCCCGACUUACCAACCCGAUGCAAACUGCGAAUACCGGAGAAUGUUAUCACGGGAGACACACGGCGGGUGCUAACGUCCGUCGUGAAGAGGGAAACAACCCAGACCGCCAGCUA	2905	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 13 (TLR13)	Toll-like receptor (TLR)	Mice	Plasma membrane	extracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domain	Q6R5N8.fasta	Q6R5N8	991	Activate NF-KB	NA	27756604	2016	Pubchem_assay
PRRID_1718	BpA Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUK6.fasta	Q9QUK6	835	Activation of caspase1	NA	27120222	2016	Pubchem_assay
PRRID_1718	BpA Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUK6.fasta	Q9QUK6	835	Activation of caspase1	NA	27120222	2016	Pubchem_assay
PRRID_1719	BpA Click for more detail	Brugia pahangi(others)	TTCTTCTTTCCATTCTTTTCCTTTCATCGTCAATTGTAGCACGGTTAAGCAATTCAGCTAATAAACACTACTTCTGCTTGATGCGTACAGGTGCCGAGGTATTGTTTATTGGCTGAGTGCTATACCTCCAGTATTCATCG	140	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	lymphatic vessels	NA	Q9QUK6.fasta	Q9QUK6	835	Activation of caspaseÔòª	NA	27120222	2016	Pubchem_assay
PRRID_1719	BpA Click for more detail	Brugia pahangi(others)	TTCTTCTTTCCATTCTTTTCCTTTCATCGTCAATTGTAGCACGGTTAAGCAATTCAGCTAATAAACACTACTTCTGCTTGATGCGTACAGGTGCCGAGGTATTGTTTATTGGCTGAGTGCTATACCTCCAGTATTCATCG	140	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	lymphatic vessels	NA	Q9QUK6.fasta	Q9QUK6	835	Activation of caspaseÔòª	NA	27120222	2016	Pubchem_assay
PRRID_1720	Calcineurin B Click for more detail	NA	MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV	170	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1720	Calcineurin B Click for more detail	NA	MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV	170	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1721	cathepsin cysteine Click for more detail	S. mansoni (others)	MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN	340	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q99MB1.fasta	Q99MB1	905	Activate STAT1	NA	27120222	2016	Pubchem_assay
PRRID_1721	cathepsin cysteine Click for more detail	S. mansoni (others)	MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN	340	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q99MB1.fasta	Q99MB1	905	Activate STAT1	NA	27120222	2016	Pubchem_assay
PRRID_1722	cathepsin cysteine Click for more detail	Schistosoma mansoni, Fasciola hepatica (Bacteria)	MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN	340	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	NA	NA	Q99MB1.fasta	Q99MB1	905	Dampen TRIF signaling by degradation of TLR3Ôòª	NA	27120222	2016	Pubchem_assay
PRRID_1722	cathepsin cysteine Click for more detail	Schistosoma mansoni, Fasciola hepatica (Bacteria)	MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN	340	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	NA	NA	Q99MB1.fasta	Q99MB1	905	Dampen TRIF signaling by degradation of TLR3Ôòª	NA	27120222	2016	Pubchem_assay
PRRID_1723	Chitin Click for more detail	Fungi	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	OsCEBiP	Receptor like proteins (RLP)	Rice	NA	a lysine motif (LysM) receptor-like protein (RLP)	NA	NA	NA	to trigger immune re- sponses.	isothermal titration calorimetry (ITC)	27238968	2016	NA
PRRID_1723	Chitin Click for more detail	Fungi	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	OsCEBiP	Receptor like proteins (RLP)	Rice	NA	a lysine motif (LysM) receptor-like protein (RLP)	NA	NA	NA	to trigger immune re- sponses.	isothermal titration calorimetry (ITC)	27238968	2016	NA
PRRID_1726	DIP Click for more detail	D. indusiata(fungi)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	RAW264.7 cells	NA	NA	NA	NA	up-regulation of nitric oxide (NO), interleukin-1Œ≤ (IL-1Œ≤), interleukin-6 (IL-6) and tumour necrosis factor (TNF-Œ±) production as well as the mRNA expression levels of iNOS, IL-1Œ≤, IL-6 and TNF-Œ± in macrophages.	Flow cytometry and confocal laser-scanning microscopy analyses	27293036	2016	NA
PRRID_1726	DIP Click for more detail	D. indusiata(fungi)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	RAW264.7 cells	NA	NA	NA	NA	up-regulation of nitric oxide (NO), interleukin-1Œ≤ (IL-1Œ≤), interleukin-6 (IL-6) and tumour necrosis factor (TNF-Œ±) production as well as the mRNA expression levels of iNOS, IL-1Œ≤, IL-6 and TNF-Œ± in macrophages.	Flow cytometry and confocal laser-scanning microscopy analyses	27293036	2016	NA
PRRID_1731	ES-62 Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUK6.fasta	Q9QUK6	835	ERK‚Üë, P38 or JNK	NA	27120222	2016	Pubchem_assay
PRRID_1731	ES-62 Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUK6.fasta	Q9QUK6	835	ERK‚Üë, P38 or JNK	NA	27120222	2016	Pubchem_assay
PRRID_1732	ES-62 Click for more detail	Acanthocheilonema viteae(others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Acanthocheilonema viteae/lymphatic tissue	NA	Q9QUK6.fasta	Q9QUK6	835	ERK‚Üë, P38 or JNK MAP‚Üì, Transient NFŒ∫B, Block mast cell degranulation	NA	27120222	2016	Pubchem_assay
PRRID_1732	ES-62 Click for more detail	Acanthocheilonema viteae(others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Acanthocheilonema viteae/lymphatic tissue	NA	Q9QUK6.fasta	Q9QUK6	835	ERK‚Üë, P38 or JNK MAP‚Üì, Transient NFŒ∫B, Block mast cell degranulation	NA	27120222	2016	Pubchem_assay
PRRID_1733	Fag Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Endotoxemia (amelioration)	NA	NA	NA	NA	NA	Inhibits LPS mediated classical activation	NA	27120222	2016	NA
PRRID_1733	Fag Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Endotoxemia (amelioration)	NA	NA	NA	NA	NA	Inhibits LPS mediated classical activation	NA	27120222	2016	NA
PRRID_1734	Fag Click for more detail	Setaria Digitata (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	abdominal cavity	NA	Q9QUK6.fasta	Q9QUK6	835	Inhibits LPS mediated classical activation	NA	27120222	2016	Pubchem_assay
PRRID_1734	Fag Click for more detail	Setaria Digitata (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	abdominal cavity	NA	Q9QUK6.fasta	Q9QUK6	835	Inhibits LPS mediated classical activation	NA	27120222	2016	Pubchem_assay
PRRID_1735	FhHDM-1 Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Sepsis (amelioration)	NA	NA	NA	NA	NA	Binding to LPS and inhibits signaling	NA	27120222	2016	NA
PRRID_1735	FhHDM-1 Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Sepsis (amelioration)	NA	NA	NA	NA	NA	Binding to LPS and inhibits signaling	NA	27120222	2016	NA
PRRID_1736	FhHDM-1 Click for more detail	Fasciola hepatica (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Fasciola hepatica/Liver	NA	Q9QUK6.fasta	Q9QUK6	835	Binding to LPS and inhibits signaling	NA	27120222	2016	Pubchem_assay
PRRID_1736	FhHDM-1 Click for more detail	Fasciola hepatica (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Fasciola hepatica/Liver	NA	Q9QUK6.fasta	Q9QUK6	835	Binding to LPS and inhibits signaling	NA	27120222	2016	Pubchem_assay
PRRID_1741	Flavolipin Click for more detail	Flavobacterium meningosepticum (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1741	Flavolipin Click for more detail	Flavobacterium meningosepticum (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1749	HDM Click for more detail	Helminths (others)	RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN	70	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUK6.fasta	Q9QUK6	835	Alter the response of B cells (‚ÜëIgGÔõú)	NA	27120222	2016	Pubchem_assay
PRRID_1749	HDM Click for more detail	Helminths (others)	RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN	70	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUK6.fasta	Q9QUK6	835	Alter the response of B cells (‚ÜëIgGÔõú)	NA	27120222	2016	Pubchem_assay
PRRID_1750	HDM Click for more detail	Schistosoma mansoni, Fasciola hepatica (Bacteria)	RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN	70	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUK6.fasta	Q9QUK6	835	Alter the response of B cells (‚ÜëIgGÔõú)	NA	27120222	2016	Pubchem_assay
PRRID_1750	HDM Click for more detail	Schistosoma mansoni, Fasciola hepatica (Bacteria)	RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN	70	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUK6.fasta	Q9QUK6	835	Alter the response of B cells (‚ÜëIgGÔõú)	NA	27120222	2016	Pubchem_assay
PRRID_1751	Heat shock protein Click for more detail	O. tsutsugamushi (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	572	Pattern-associated molecular patterns (PAMPs)	Natural	Cause Scrub typhus, immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	HEK293 cells	TIR domain	Q9QUN7.fasta	Q9QUN7	784	secretion of TNF-Œ± and IL-6 by dendritic cells	ELISA	27620720	2016	Pubchem_assay
PRRID_1751	Heat shock protein Click for more detail	O. tsutsugamushi (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	572	Pattern-associated molecular patterns (PAMPs)	Natural	Cause Scrub typhus, immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	HEK293 cells	TIR domain	Q9QUN7.fasta	Q9QUN7	784	secretion of TNF-Œ± and IL-6 by dendritic cells	ELISA	27620720	2016	Pubchem_assay
PRRID_1752	High-mannose and fucose glycans Click for more detail	Mycobacterium spp., H. pylori, Lactobacillus spp., Leishmania spp., HIV-1, Dengue virus, Measles vir	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	DC-SIGN	C type Lectin (CTL/CLR)	Human	NA	NA	Q9H2X3.fasta	Q9H2X3	399	Pathogen recognition; Antigen uptake; APC/T cell interactions; Cell migration	NA	27999992	2016	Pubchem_assay
PRRID_1752	High-mannose and fucose glycans Click for more detail	Mycobacterium spp., H. pylori, Lactobacillus spp., Leishmania spp., HIV-1, Dengue virus, Measles vir	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	DC-SIGN	C type Lectin (CTL/CLR)	Human	NA	NA	Q9H2X3.fasta	Q9H2X3	399	Pathogen recognition; Antigen uptake; APC/T cell interactions; Cell migration	NA	27999992	2016	Pubchem_assay
PRRID_1753	High-mannose glycans Click for more detail	M. tuberculosis, S. enterica, S. mansoni, C. albicans, A. fumigatus, Malassezia spp.(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Dectin-2	C type Lectin (CTL/CLR)	Human	NA	NA	Q6EIG7.fasta	Q6EIG7	209	Pathogen recognition; antigen uptake	NA	27999992	2016	Pubchem_assay
PRRID_1753	High-mannose glycans Click for more detail	M. tuberculosis, S. enterica, S. mansoni, C. albicans, A. fumigatus, Malassezia spp.(Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Dectin-2	C type Lectin (CTL/CLR)	Human	NA	NA	Q6EIG7.fasta	Q6EIG7	209	Pathogen recognition; antigen uptake	NA	27999992	2016	Pubchem_assay
PRRID_1754	HSP Gp96 Click for more detail	NA	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1754	HSP Gp96 Click for more detail	NA	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1755	HSP70L1 Click for more detail	NA	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1755	HSP70L1 Click for more detail	NA	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Activate NF-Kb	NA	27293318	2016	NA
PRRID_1756	Lewis antigens Click for more detail	Mycobacterium spp., H. pylori, Lactobacillus spp., Leishmania spp., HIV-1, Dengue virus, Measles vir	CC1C(C(C(C(O1)OC2C(C(OC(C2OC3C(C(C(C(O3)CO)O)O)O)CO)O)NC(=O)C)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	DC-SIGN	C type Lectin (CTL/CLR)	Human	NA	NA	Q9H2X3.fasta	Q9H2X3	399	Pathogen recognition; Antigen uptake; APC/T cell interactions; Cell migration	NA	27999992	2016	Pubchem_assay
PRRID_1756	Lewis antigens Click for more detail	Mycobacterium spp., H. pylori, Lactobacillus spp., Leishmania spp., HIV-1, Dengue virus, Measles vir	CC1C(C(C(C(O1)OC2C(C(OC(C2OC3C(C(C(C(O3)CO)O)O)O)CO)O)NC(=O)C)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	DC-SIGN	C type Lectin (CTL/CLR)	Human	NA	NA	Q9H2X3.fasta	Q9H2X3	399	Pathogen recognition; Antigen uptake; APC/T cell interactions; Cell migration	NA	27999992	2016	Pubchem_assay
PRRID_1757	Lipopeptides Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	F1QWS9.fasta	F1QWS9	818	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1757	Lipopeptides Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	F1QWS9.fasta	F1QWS9	818	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1760	lipophosphoglycans (LPG) Click for more detail	Leishmania infantum (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Causes visceral and cutaneous leishmaniasis, immunomodulatory	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	activate MAPKs and the NF-Œ∫B inhibitor p-IŒ∫BŒ±,	NA	27508930	2016	Pubchem_assay
PRRID_1760	lipophosphoglycans (LPG) Click for more detail	Leishmania infantum (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Causes visceral and cutaneous leishmaniasis, immunomodulatory	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	activate MAPKs and the NF-Œ∫B inhibitor p-IŒ∫BŒ±,	NA	27508930	2016	Pubchem_assay
PRRID_1761	lipophosphoglycans (LPG) Click for more detail	Leishmania braziliensis (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Causes visceral and cutaneous leishmaniasis, immunomodulatory	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	activate MAPKs and the NF-Œ∫B inhibitor p-IŒ∫BŒ±,	NA	27508930	2016	Pubchem_assay
PRRID_1761	lipophosphoglycans (LPG) Click for more detail	Leishmania braziliensis (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Causes visceral and cutaneous leishmaniasis, immunomodulatory	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	activate MAPKs and the NF-Œ∫B inhibitor p-IŒ∫BŒ±,	NA	27508930	2016	Pubchem_assay
PRRID_1794	LNFPlll Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Psoriasis, TypeÔõú diabet, EAE (amelioration)	NA	NA	NA	NA	NA	NFŒ∫B‚Üë	NA	27120222	2016	NA
PRRID_1794	LNFPlll Click for more detail	Helminths (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Psoriasis, TypeÔõú diabet, EAE (amelioration)	NA	NA	NA	NA	NA	NFŒ∫B‚Üë	NA	27120222	2016	NA
PRRID_1795	LNFPlll Click for more detail	S. mansoni (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	blood vessels(human and mice)	NA	Q9QUK6.fasta	Q9QUK6	835	NFŒ∫B‚Üë	NA	27120222	2016	Pubchem_assay
PRRID_1795	LNFPlll Click for more detail	S. mansoni (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	blood vessels(human and mice)	NA	Q9QUK6.fasta	Q9QUK6	835	NFŒ∫B‚Üë	NA	27120222	2016	Pubchem_assay
PRRID_1798	LPS (HDM and fungal allergens) Click for more detail	NA	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUK6.fasta	Q9QUK6	835	Controversial (induce or inhibit)	NA	27120222	2016	Pubchem_assay
PRRID_1798	LPS (HDM and fungal allergens) Click for more detail	NA	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUK6.fasta	Q9QUK6	835	Controversial (induce or inhibit)	NA	27120222	2016	Pubchem_assay
PRRID_1799	Lyso-PS lipids Click for more detail	S. mansoni (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUN7.fasta	Q9QUN7	784	ND	NA	27120222	2016	Pubchem_assay
PRRID_1799	Lyso-PS lipids Click for more detail	S. mansoni (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUN7.fasta	Q9QUN7	784	ND	NA	27120222	2016	Pubchem_assay
PRRID_1800	Lyso-PS lipids Click for more detail	S. mansoni (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUN7.fasta	Q9QUN7	784	ND	NA	27120222	2016	Pubchem_assay
PRRID_1800	Lyso-PS lipids Click for more detail	S. mansoni (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUN7.fasta	Q9QUN7	784	ND	NA	27120222	2016	Pubchem_assay

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