Detailed description page of PRRDB2.0
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PRRID_2209 details |
| Primary information | |
|---|---|
| PRRID | PRRID_2209 |
| Ligand Name | Imidazoquinoline |
| Source | NA |
| Sequence of ligand | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N |
| Length | NA |
| Type | Pattern-associated molecular patterns (PAMPs) |
| Occurence | Natural |
| Role of Ligand | Synthesis of IFNα, inflammatory cytokine production by macrophages, proliferation of splenocytes or maturation of DCs , Produce type I IFNs and other cytokines, maturation of pDCs, stimulate T-cells ,Reduces plasma virus concentration in chronic hepatitis C infection |
| Name of receptor | Toll-like receptor 7 (TLR7) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Mice |
| Localization | NA |
| Domain | Leucine-rich Repeat (LRR) Domain |
| Sequence of Receptor | P58681.fasta |
| Swiss prot ID | P58681 |
| Length Of Receptor | 1050 |
| Function | NA |
| Assay used | NA |
| PMID | 29028369 |
| Year of Publication | 2017 |
| Pubchem assay | Pubchem_assay |
| Primary information | |
|---|---|
| PRRID | PRRID_2209 |
| Ligand Name | Imidazoquinoline |
| Source | NA |
| Sequence of ligand | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N |
| Length | NA |
| Type | Pattern-associated molecular patterns (PAMPs) |
| Occurence | Natural |
| Role of Ligand | Synthesis of IFNα, inflammatory cytokine production by macrophages, proliferation of splenocytes or maturation of DCs , Produce type I IFNs and other cytokines, maturation of pDCs, stimulate T-cells ,Reduces plasma virus concentration in chronic hepatitis C infection |
| Name of receptor | Toll-like receptor 7 (TLR7) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Mice |
| Localization | NA |
| Domain | Leucine-rich Repeat (LRR) Domain |
| Sequence of Receptor | P58681.fasta |
| Swiss prot ID | P58681 |
| Length Of Receptor | 1050 |
| Function | NA |
| Assay used | NA |
| PMID | 29028369 |
| Year of Publication | 2017 |
| Pubchem assay | Pubchem_assay |