| Primary information |
|---|
| PRRID | PRRID_1112 |
| Ligand Name | ODN2006 |
| Source | oligonucleotides containing unmethylated CpG dinucleotides (others) |
| Sequence of ligand | 5’-tcgtcgttttgtcgttttgtcgtt-3’ |
| Length | 24 |
| Type | Pattern-associated molecular patterns (PAMPs) |
| Occurence | Synthetic |
| Role of Ligand | induce strong immunostimulatory effects trough activation of TLR9 in mammalian cells and type B CpG ODN2006 significantly induced IL-1b and IFN-a1 |
| Name of receptor | Toll-like receptor 9 (TLR9) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | HEK293 cells |
| Domain | NA |
| Sequence of Receptor | Q9NR96.fasta |
| Swiss prot ID | Q9NR96 |
| Length Of Receptor | 1032 |
| Function | TLR9 plays a crucial role in breaking tolerance and developing autoimmunity |
| Assay used | NF- |
| PMID | 24098508 |
| Year of Publication | 2013 |
| Pubchem assay | Pubchem_assay |
| Primary information |
|---|
| PRRID | PRRID_1112 |
| Ligand Name | ODN2006 |
| Source | oligonucleotides containing unmethylated CpG dinucleotides (others) |
| Sequence of ligand | 5’-tcgtcgttttgtcgttttgtcgtt-3’ |
| Length | 24 |
| Type | Pattern-associated molecular patterns (PAMPs) |
| Occurence | Synthetic |
| Role of Ligand | induce strong immunostimulatory effects trough activation of TLR9 in mammalian cells and type B CpG ODN2006 significantly induced IL-1b and IFN-a1 |
| Name of receptor | Toll-like receptor 9 (TLR9) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | HEK293 cells |
| Domain | NA |
| Sequence of Receptor | Q9NR96.fasta |
| Swiss prot ID | Q9NR96 |
| Length Of Receptor | 1032 |
| Function | TLR9 plays a crucial role in breaking tolerance and developing autoimmunity |
| Assay used | NF- |
| PMID | 24098508 |
| Year of Publication | 2013 |
| Pubchem assay | Pubchem_assay |